Substituted pyrazolo-pyridine amides and their use as glun2b receptor

ABSTRACT

Substituted Pyrazolo-pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the priority benefit of U.S. provisional application No. 62/861,656, filed Jun. 14, 2019 and Argentinian application no. P 20 01 01623, filed Jun. 9, 2020, the contents of each of which are incorporated herein in their entireties by reference thereto.

FIELD OF THE INVENTION

The present invention is related to compounds having GluN2B modulating properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with GluN2B receptor activity in animals, in particular humans.

BACKGROUND OF THE INVENTION

Glutamate is one of the major excitatory neurotransmitters that is widely spread in the brain. First indication of its role as an excitatory messenger was in the 1950's when it was observed that intravenous administration of glutamate induces convulsions. However, the detection of the whole glutamatergic neurotransmitter system with its various receptors did not take place before the 1970's and 1980's when numerous antagonists were developed or, as in the case of PCP and ketamine, were identified as antagonists. Finally, in the 1990's molecular biology provided the tools for the classification of the glutamatergic receptors.

N-methyl-D-aspartate (NMDA) receptors are a subtype of ionotropic glutamate receptors that mediate excitatory synaptic transmission in the brain. NMDA receptors are ubiquitously distributed throughout the brain and play a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. NMDA receptors are distinct from other major subtypes of ionotropic glutamate receptors (AMPA and kainate receptors) in that they are blocked by Mg²⁺ at resting membrane potentials, are highly Ca²⁺ permeable, and require co-activation by two distinct neurotransmitters: glutamate and glycine (or D-serine) (Traynelis S F et al., Pharmacol Rev. 2010; 62(3):405-96). The influx of Ca²⁺ through NMDA receptors triggers signaling cascades and regulates gene expression that is critical for different forms of synaptic plasticity including both long-term potentiation of synapse efficacy (LTP) (Berberich S et al., Neuropharmacology 2007; 52(1):77-86) and long-term depression (LTD) (Massey, P V et al., J Neurosci. 2004 Sep. 8; 24(36):7821-8).

The vast majority of the mammalian NMDA receptors form a heterotetramer made of two obligatory GluN1 units and two variable GluN2 receptor subunits encoded by the GRIN1 gene and one of four GRIN2 genes, respectively. One or both GluN2 subunits can be potentially replaced by a GluN3A or a GluN3B subunit. The GRIN1 gene product has 8 splice variants while there are 4 different GRIN2 genes (GRIN2A-D) encoding four distinct GluN2 subunits. The glycine binding site is present on the GluN1 subunit and the glutamate binding site is present on the GluN2 subunit.

The GluNR2 subunits play a dominant role in determining the functional and pharmacological properties of the NMDA receptor assembly and exhibit distinct distribution in different areas of the brain. For instance, GluN2B subunits are expressed primarily in the forebrain in the adult mammalian brain (Paoletti P et al., Nat Rev Neurosci. 2013; 14(6):383-400; Watanabe M et al., J Comp Neurol. 1993; 338(3):377-90) and are implicated in learning, memory processing, mood, attention, emotion and pain perception (Cull-Candy S et al., Curr Opin Neurobiol. 2001; 11(3):327-35).

Compounds that modulate GluN2B-containing NMDA receptor function can be useful in treatment of many neurological and psychiatric disorders including but not limited to bipolar disorder (Martucci L et al., Schizophrenia Res, 2006; 84(2-3):214-21), major depressive disorder (Miller O H et al., eLife. 2014; 3:e03581; Li N et al., Biol Psychiatry. 2011; 69(8):754-61), treatment-resistant depression (Preskorn S H et al. J Clin Psychopharmacol. 2008; 28(6):631-7) and ther mood disorders (including schizophrenia (Grimwood S et al., Neuroreport. 1999; 10(3):461-5; Weickert C S et al. Molecular Psychiatry (2013) 18, 1185-1192), ante- and postpartum depression, seasonal affective disorder and the like), Alzheimer's disease (Hanson J E et al., Neurobiol Dis. 2015; 74:254-62; Li S et al., J Neurosci. 2011; 31(18):6627-38) and other dementias (Orgogozo J M et al. Stroke 2002, 33: 1834-1839), Parkinson's disease (Duty S, CNS Drugs. 2012; 26(12):1017-32; Steece-Collier K et al., Exp Neurol. 2000; 163(1):239-43; Leaver K R et al. Clin Exp Pharmacol Physiol. 2008; 35(11):1388-94), Huntington's chorea (Tang T S et al., Proc Natl Acad Sci USA. 2005; 102(7):2602-7; Li L et al., J Neurophysiol. 2004; 92(5):2738-46), multiple sclerosis (Grasselli G et al., Br J Pharmacol. 2013; 168(2):502-17; Farjam M et al., Iran J Pharm Res. 2014; 13(2):695-705), cognitive impairment (Wang D et al. 2014, Expert Opin Ther Targets Expert Opin Ther Targets. 2014; 18(10):1121-30), head injury (Bullock M R et al., Ann NY Acad Sci. 1999; 890:51-8), spinal cord injury, stroke (Yang Y et al., J Neurosurg. 2003; 98(2):397-403), epilepsy (Naspolini A P et al., Epilepsy Res. 2012 June; 100(1-2):12-9), movement disorders (e.g. dyskinesias) (Morissette M et al., Mov Disord 2006; 21(1):9-17), various neurodegenerative diseases (e.g. amyotrophic lateral sclerosis (Fuller P I et al., Neurosci Lett. 2006; 399(1-2):157-61) or neurodegeneration associated with bacterial or chronic infections), glaucoma (Naskar R et al. Semin Ophthalmol. 1999 September; 14(3):152-8), pain (e.g. chronic, cancer, post-operative and neuropathic pain (Wu L J and Zhuo M, Neurotherapeutics. 2009; 6(4):693-702), diabetic neuropathy, migraine (Peeters M et al., J Pharmacol Exp Ther. 2007; 321(2):564-72), cerebral ischemia (Yuan H et al., Neuron. 2015; 85(6):1305-18), encephalitis (Dalmau J. et al., Lancet Neurol. 2008; 7(12):1091-8.), autism and autism spectrum disorders (Won H. et al., Nature. 2012; 486(7402):261-5), memory and learning disorders (Tang, Y. P. et al., Nature. 1999; 401(6748):63-9), obsessive compulsive disorder (Arnold P D et al., Psychiatry Res. 2009; 172(2):136-9.), attention deficit hyperactivity disorder (ADHD) (Dorval K M et al., Genes Brain Behav. 2007; 6(5):444-52), PTSD (Haller J et al. Behav Pharmacol. 2011; 22(2):113-21; Leaderbrand K et al. Neurobiol Learn Mem. 2014; 113:35-40), tinnitus (Guitton M J, and Dudai Y, Neural Plast. 2007; 80904; Hu S S et al. 2016; 273(2): 325-332), sleep disorders (like narcolepsy or excessive daytime sleepiness, patent W O 2009058261 A1), vertigo and nystagmus (Straube A. et al., Curr Opin Neurol. 2005; 18(1):11-4; Starck M et al. J Neurol. 1997 January; 244(1):9-16), anxiety autoimmunological disorders like neuropsychiatric systemic lupus erythematosus (Kowal C et al. Proc. Natl. Acad. Sci. U.S.A. 2006; 103, 19854-19859) and addictive illnesses (e.g. alcohol addiction, drug addiction) (Nagy J, 2004, Curr Drug Targets CNS Neurol Disord 2004; 3(3):169-79.; Shen H et al., Proc Natl Acad Sci USA. 2011; 108(48):19407-12).

In view of the clinical importance of GluN2B, the identification of compounds that modulate GluN2B receptor function represents an attractive avenue into the development of new therapeutic agents. Such compounds are provided herein.

SUMMARY OF THE INVENTION

The invention is directed to the general and preferred embodiments defined, respectively, by the independent and dependent claims appended hereto, which are incorporated by reference herein. One aspect of this invention concerns compounds of Formula (I):

wherein

-   -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2;         and pharmaceutically acceptable salts, stereoisomers, isotopic         variants, N-oxides, or solvates of compounds of Formula (I).

Further embodiments are provided by pharmaceutically acceptable salts of compounds of Formulas (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I).

In certain embodiments, the compounds of Formula (I) are compounds selected from those species described or exemplified in the detailed description below.

In a further aspect, the invention relates to enantiomers and diastereomers of the compounds of Formula (I), as well as the pharmaceutically acceptable salts.

In a further aspect, the invention relates to pharmaceutical compositions for treating a disease, disorder, or medical condition mediated by GluN2B receptor activity, comprising an effective amount of at least one compound selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of Formula (I).

Pharmaceutical compositions according to the invention may further comprise one or more pharmaceutically acceptable excipients.

In another aspect, the chemical embodiments of the present invention are useful as GluN2B receptor modulators. Thus, the invention is directed to a method for modulating GluN2B receptor activity, including when such receptor is in a subject, comprising exposing GluN2B receptor to an effective amount of at least one compound selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I).

In another aspect, the invention is directed to a method of treating a subject suffering from, or diagnosed with a disease, disorder, or medical condition mediated by GluN2B receptor activity, comprising administering to the subject in need of such treatment an effective amount of at least one compound selected from compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of compounds of Formula (I). Additional embodiments of methods of treatment are set forth in the detailed description.

In another aspect, the method of studying isotopically labeled compounds in metabolic studies (preferably with ¹⁴C), reaction kinetic studies (with, for example ²H or ³H), detection or imaging techniques [such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT)] including drug or substrate tissue distribution assays, or in radioactive treatment of patients. For example, an ¹⁸F or ¹¹C labeled compound may be particularly preferred for PET or SPECT studies.

Additional embodiments of this invention include methods of making compounds of Formula (I), pharmaceutically acceptable salts of compounds of Formula (I), pharmaceutically acceptable prodrugs of compounds of Formula (I), and pharmaceutically active metabolites of Formula (I).

An object of the present invention is to overcome or ameliorate at least one of the disadvantages of the conventional methodologies and/or prior art, or to provide a useful alternative thereto.

Additional embodiments, features, and advantages of the invention will be apparent from the following detailed description and through practice of the invention.

DETAILED DESCRIPTION OF INVENTION

In one aspect, provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, stereoisomers, isotopic variants, N-oxides, or solvates thereof,

wherein

-   -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2.

An additional embodiment of the invention is a compound of Formula (I) wherein R¹ is H.

An additional embodiment of the invention is a compound of Formula (I) wherein R¹ is F.

An additional embodiment of the invention is a compound of Formula (I) wherein R¹ is CH₃.

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is phenyl substituted with one member selected from the group consisting of: Cl, F, CH₃, OCH₃, CH₂F, CHF₂, CF₃, CHF₂CH₃, OCHF₂, CN, and cyclopropyl.

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is phenyl substituted with two members each independently selected from the group consisting of: Cl, F, CH₃, CHF₂, CF₃, CHF₂CH₃, OCH₃, OCHF₂, and (C═O)CH₃.

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is phenyl substituted with three members each independently selected from the group consisting of: halo, and CH₃.

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is thienyl independently substituted with one or two members selected from: Cl, CH₃, CF₃ and CHF₂.

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein Ar¹ is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is

wherein

-   R^(a) is each independently selected from the group consisting of:     H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃, ═CH₂, CH═CH₂,     CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH, CH(OH)(CH₃), CH₂OCH₃,     OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃), NHCO₂CH₃, NHC(═O)CH₃,     NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂,     C(═O)CH₃, CN, NHSO₂CH₃, SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl,     3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and pyrrolidine-2-one; or two     R^(a) members combine to form a cyclopropyl, cyclobutyl, or     oxetanyl; wherein the cyclopropyl is optionally substituted one or     two F members; -   and n is 1 or 2.

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein R² is selected from the group consisting of:

An additional embodiment of the invention is a compound of Formula (I) wherein n is 1.

An additional embodiment of the invention is a compound of Formula (I) wherein n is 2.

An additional embodiment of the invention is a compound of Formula (I) wherein m is 1.

An additional embodiment of the invention is a compound of Formula (I) wherein m is 2.

An additional embodiment of the invention is a compound of Formula (I), having the structure of Formula (IA):

wherein

-   -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R^(a) is each independently selected from the group consisting         of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl, C₂₋₆alkenyl,         C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH, CH(OH)(CH₃), CH₂OCH₃,         OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃), NHCO₂CH₃, NHC(═O)CH₃,         NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂,         C(═O)CH₃, CN, NHSO₂CH₃, SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl,         3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and pyrrolidine-2-one; or         two R^(a) members combine to form a C₃₋₆cycloalkyl or         heterocycloalkyl, wherein the C₃₋₆cycloalkyl and         heterocycloalkyl is optionally substituted one or two F members;         and     -   n is 1 or 2.

An additional embodiment of the invention is a compound of Formula (IA), wherein

-   -   R¹ is H, F, or CH₃;     -   Ar¹ is phenyl substituted with two or three members each         independently selected from the group consisting of: halo,         C₁₋₄alkyl, C₁₋₄perhaloalkyl, OC₁₋₄alkyl, and OC₁₋₄perhaloalkyl;         -   R^(a) is each independently selected from the group             consisting of: H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃,             ═CH₂, CH═CH₂, CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)CH₃, CN, NHSO₂CH₃, 1H-imidazol-2-yl,             2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and             pyrrolidine-2-one; or two R^(a) members combine to form a             cyclopropyl, cyclobutyl, or oxetanyl; wherein the             cyclopropyl is optionally substituted one or two F members;     -   and n is 1 or 2.

An additional embodiment of the invention is a compound of Formula (IA), wherein R¹ is H.

An additional embodiment of the invention is a compound of Formula (I) having the Formula (IB):

wherein

-   -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;

Ring

is selected from the group consisting of:

-   -   R^(b) is each independently selected from the group consisting         of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or two R^(b)         members come together to form ═O;     -   n is 1 or 2; and     -   m is 1 or 2.

An additional embodiment of the invention is a compound of Formula (IB), wherein Ring

is

An additional embodiment of the invention is a compound of Formula (I) having the Formula (IC):

wherein

-   -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;         CH₂CH═CH₂; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;         NH—C(═O)CH₃; cyclopropyl; cyclobutyl; 3-bicyclo[1.1.1]pentanyl;         3,3-difluorocyclobutyl; 1-methylazetidin-3-yl; and oxetan-3-yl;         and     -   R^(e) is H or CH₃.

An additional embodiment of the invention is a compound of Formula (IC), wherein Ar¹ is

A further embodiment of the current invention is a compound as shown below in Table 1.

Example # Compound Name  1 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-[3-hydroxy-3-(trifluoromethyl)azetidin- 1-yl]ethanone;  2 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3-methyleneazetidin-1-yl)ethanone;  3 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone;  4 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]- N-methyl-acetamide;  5 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  6 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide;  7 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide;  8 N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl] pyrazolo[4,3-b]pyridin-1-yl]acetamide;  9 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl) ethanone;  10 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide;  11 N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetamide;  12 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone;  13 1-Morpholino-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]ethanone;  14 N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetamide;  15 N-(1-Methylazetidin-3-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide;  16 1-(3-Fluoroazetidin-1-yl)-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone;  17 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2,4-difluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  18 1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  19 1-(Azetidin-1-yl)-2-[6-[5-(difluoromethyl)- 2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  20 1-(Azetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)- 2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  21 1-(Azetidin-1-yl)-2-[6-(4-fluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  22 1-(Azetidin-1-yl)-2-[6-(3-chlorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  23 1-(Azetidin-1-yl)-2-[6-[3-(fluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  24 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  25 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  26 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl) phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  27 1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  28 1-(Azetidin-1-yl)-2-[3-methyl-6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  29 1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  30 1-(Azetidin-1-yl)-2-[6-(2,3-dichlorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  31 1-(Azetidin-1-yl)-2-[6-(3-chloro-2-fluoro- phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone;  32 1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  33 1-(Azetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  34 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  35 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  36 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b] pyridin-1-yl]ethanone;  37 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b] pyridin-1-yl]ethanone;  38 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  39 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)- 3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  40 1-(Azetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  41 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  42 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)- 4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b] pyridin-1-yl]ethanone;  43 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  44 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy) phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  45 1-(Azetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  46 2-[6-(3-Acetyl-4-fluoro-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(azetidin-1-yl)ethanone;  47 1-(Azetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  48 1-(Azetidin-1-yl)-2-[6-[2-(trifluoromethyl)- 4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  49 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  50 2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrazolo[4,3- b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  51 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  52 2-[6-[5-(Difluoromethyl)-2-thienyl]-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]- 1-(3-fluoroazetidin-1-yl)ethanone;  53 1-(3-Fluoroazetidin-1-yl)-2-[6-[5- (trifluoromethyl)-2-thienyl]pyrazolo[4,3- b]pyridin-1-yl]ethanone;  54 1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[5- (trifluoromethyl)-2-thienyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone;  55 1-(3-Fluoroazetidin-1-yl)-2-[6-(3-fluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  56 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  57 2-[6-[3-Chlorophenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  58 1-(3-Fluoroazetidin-1-yl)-2-[6-(m-tolyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  59 1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(fluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  60 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  61 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  62 2-[6-[3-(Difluoromethoxy)phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  63 2-[6-(2,3-Difluorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  64 2-[6-(2,4-Difluorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  65 2-[6-(3,4-Difluorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  66 2-[6-(3,5-Difluorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  67 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  68 2-[6-(3-Chloro-4-fluorophenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  69 1-(3-Chloroazetidin-1-yl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  70 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3- fluoroazetidin-1-yl)ethanone;  71 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3- methyl-pyrazolo[4,3-b]pyridin-1-yl]-1-(3- fluoroazetidin-1-yl)ethanone;  72 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  73 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3- fluoroazetidin-1-yl)ethanone;  74 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  75 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]- 3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1- (3-fluoroazetidin-1-yl)ethanone;  76 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  77 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  78 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy- phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone;  79 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  80 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]- 3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1- (3-fluoroazetidin-1-yl)ethanone;  81 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]- 3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1- (3-fluoroazetidin-1-yl)ethanone;  82 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  83 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  84 1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone;  85 1-(3-Fluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)- 4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  86 1-(3-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  87 (Racemic) 1-(2-Methylazetidin-1-yl)-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone;  88 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin- 1-yl)ethanone;  89 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3- methylazetidin-1-yl)ethanone;  90 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1- (2-methylazetidin-1-yl)ethanone;  91 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone;  92 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3- fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3- methylazetidin-1-yl)ethanone;  93 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro- pyrazolo[4,3-b]pyridin-1-yl]-1-(3- methylazetidin-1-yl)ethanone;  94 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3- ethynylazetidin-1-yl)ethanone;  95 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-vinylazetidin- 1-yl)ethanone;  96 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-prop- 1-enyl]azetidin-1-yl]ethanone;  97 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3- (fluoromethyl)azetidin-1-yl]ethanone;  98 1-[3-(Difluoromethyl)azetidin-1-yl]-2-[6-[3- (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone;  99 1-[3-(Trifluoromethyl)azetidin-1-yl]-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 100 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-[3-(trifluoromethyl)azetidin- 1-yl]ethanone; 101 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[3-[(Z)-2-fluorovinyl] azetidin-1-yl]ethanone; 102 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[3-(2,2-difluorovinyl) azetidin-1-yl]ethanone; 103 1-(3-Methoxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 104 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3-methoxyazetidin-1-yl)ethanone; 105 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-ethoxyazetidin-1-yl)ethanone; 106 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-[3-(methoxymethyl)azetidin-1-yl] ethanone; 107 1-[3-(Methoxymethyl)azetidin-1-yl]-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 108 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1-hydroxyethyl) azetidin-1-yl]ethanone; 109 1-[3-(Difluoromethoxy)azetidin-1-yl]-2-[6-[3- (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 110 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[3-(trifluoromethoxy) azetidin-1-yl]ethanone; 111 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; 112 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro- pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin- 1-yl)ethanone; 113 1-(3-Hydroxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 114 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(hydroxymethyl) azetidin-1-yl]ethanone; 115 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-methyl-2-thienyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone; 116 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone; 117 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 118 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo [4,3-b]pyridin-1-yl]ethanone; 119 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3- (difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin- 1-yl]ethanone; 120 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 121 3-[1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl] pyrazolo[4,3-b]pyridin-6-yl]benzonitrile; 122 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[6-(trifluoromethyl)- 2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 123 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)- 4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 124 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)- 3-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 125 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4-difluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone; 126 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,5-difluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]ethanone; 127 2-[6-[3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 128 2-[6-[3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 129 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-3- methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 130 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2- methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 131 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2-fluoro-3-methyl- phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 132 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 133 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[4-fluoro-3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 134 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-5- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 135 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-methyl-3- (trifluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 136 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2- methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl] ethanone; 137 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4,5- trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl] ethanone; 138 1-(3,3-Dimethylazetidin-1-yl)-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin- 1-yl]ethanone; 139 1-(3-Fluoro-3-methyl-azetidin-1-yl)-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin- 1-yl]ethanone; 140 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3- dimethylazetidin-1-yl)ethanone; 141 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3- methyl-azetidin-1-yl)ethanone; 142 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-fluoro- azetidin-1-yl)ethanone; 143 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3- (fluoromethyl)azetidin-1-yl]ethanone; 144 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxy-3- methyl-azetidin-1-yl)ethanone; 145 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-ethyl-3-hydroxy- azetidin-1-yl)ethanone; 146 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3- methyl-azetidin-1-yl)ethanone; 147 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro- 3-(hydroxymethyl)azetidin-1-yl]ethanone; 148 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3- (methoxymethyl)azetidin-1-yl]ethanone; 149 [6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-2- methyl-azetidin-1-yl)ethanone; 150 1-[2-[6-[3-(Trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl] azetidine-3-carbonitrile; 151 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl] azetidine-3-carbonitrile; 152 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3- methyl-azetidine-3-carbonitrile; 153 1-(3-Acetylazetidin-1-yl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 1-yl]ethanone; 154 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl] azetidin-3-yl]acetamide; 155 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]-N,N- dimethyl-azetidine-3-carboxamide; 156 MethylN-[1-[2-[6-[3-(difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl] azetidin-3-yl]carbamate; 157 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1- yl]acetyl]azetidin-3-yl]-2,2,2-trifluoro-acetamide; 158 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl] azetidin-3-yl]cyclopropanecarboxamide; 159 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl] methanesulfonamide; 160 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-methylsulfonylazetidin-1-yl) ethanone; 161 1-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3- yl]pyrrolidin-2-one; 162 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[3-(1H-imidazol-2-yl) azetidin-1-yl]ethanone; 163 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[3-(4-pyridyl)azetidin-1- yl]ethanone; 164 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3-pyrimidin-4-ylazetidin- 1-yl)ethanone; 165 1-(5-Azaspiro[2.3]hexan-5-yl)-2-[6-[3- (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 166 1-(2,2-Difluoro-5-azaspiro[2.3]hexan-5-yl)-2- [6-[3-(difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]ethanone; 167 1-(6-Azaspiro[3.3]heptan-6-yl)-2-[6-[3- (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 168 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-oxa-6- azaspiro[3.3]heptan-6-yl)ethanone; 169 1-(6-Oxa-2-azaspiro[3.3]heptan-2-yl)-2- [6-[3-(trifluoromethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]ethanone; 170 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-1-pyrrolidin-1-yl-ethanone; 171 1-Pyrrolidin-1-yl-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]ethanone; 172 2-[6-(3-Cyclopropylphenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 173 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 174 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 175 2-[6-(3,5-Difluoro-4-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 176 1-[(3R)-3-Fluoropyrrolidin-1-yl]-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 177 1-[(3S)-3-Fluoropyrrolidin-1-yl]-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl] ethanone; 178 (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1- (3-fluoropyrrolidin-1-yl)ethanone; 179 (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1- (3-fluoropyrrolidin-1-yl)ethanone; 180 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[(3R)-3- fluoropyrrolidin-1-yl]ethanone; 181 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[(3S)-3-fluoropyrrolidin- 1-yl]ethanone; 182 (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1- (3-hydroxypyrrolidin-1-yl)ethanone; 183 (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3- hydroxypyrrolidin-1-yl)ethanone; 184 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxypyrrolidin- 1-yl)ethanone; 185 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[(2R)-2- (methoxymethyl)pyrrolidin-1-yl]ethanone; 186 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-[(2S)-2- (methoxymethyl)pyrrolidin-1-yl]ethanone; 187 N-[(3S)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl] pyrrolidin-3-yl]acetamide; 188 N-[(3R)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl] pyrrolidin-3-yl]acetamide; 189 1-(3,3-Difluoropyrrolidin-1-yl)-2-[6-[3- (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 190 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; 191 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1- yl)ethanone; 192 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl- pyrrolidin-1-yl)ethanone; 193 (Racemic) Trans-2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro- 4-hydroxy-pyrrolidin-1-yl)ethanone; 194 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin- 3-one; 195 1-[2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; 196 1-(1-Piperidyl)-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]ethanone; 197 1-(4,4-Difluoro-1-piperidyl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 198 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetyl]-4-piperidyl] acetamide; 199 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]- 1-morpholino-ethanone; 200 1-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-3-yl]-2-[6- [3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]ethanone; 201 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[(1S,4S)-2-oxa-5- azabicyclo[2.2.1]heptan-5-yl]ethanone; 202 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-1-[(1R,4R)-2-oxa-5-azabicyclo [2.2.1]heptan-5-yl]ethanone; 203 (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]- 3a,4,6,6a-tetrahydro-3H-pyrrolo[3,4-d]oxazol-2-one; 204 (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]- 1,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-2-one; 205 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 206 N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2- thienyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 207 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin- 1-yl]-N,N-dimethyl-acetamide; 208 2-[6-(5-Chloro-4-methyl-2-thienyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 209 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 210 2-[6-[3-(Difluoromethyl)phenyl]-3-fluoro- pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 211 2-[3-Fluoro-6-(4-fluorophenyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 212 2-[3-Fluoro-6-(3-fluorophenyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 213 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1- yl]-N,N-dimethyl-acetamide; 214 N,N-Dimethyl-2-[6-[2-(trifluoromethyl)-4- pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 215 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N-methyl-acetamide; 216 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N-ethyl-acetamide; 217 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N-ethyl-N-methyl-acetamide; 218 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro- pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 219 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl- pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 220 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 221 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 222 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-N-methyl-acetamide; 223 2-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 224 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 225 2-[6-[3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 226 2-[6-(3,4-Dichlorophenyl)pyrazolo[4,3-b]pyridin- 1-yl]-N,N-dimethyl-acetamide; 227 2-[6-(3,5-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 228 2-[6-(3,4-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b] pyridin-1-yl]-N,N-dimethyl-acetamide; 229 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 230 2-[6-[3-(1,1-Difluoroethyl)phenyl]-3-fluoro- pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 231 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 232 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]- 3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N- dimethyl-acetamide; 233 2-[6-[2-Fluoro-3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 234 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N-(2-methoxyethyl)- N-methyl-acetamide; 235 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N-(2-hydroxyethyl)- N-methyl-acetamide; 236 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl] pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-N- (2,2,2-trifluoroethyl)acetamide; 237 N-(Cyanomethyl)-2-[6-[3-(difluoromethyl)-4- fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]- N-methyl-acetamide; 238 N-Allyl-2-[6-[3-(difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N- methyl-acetamide; 239 N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl) pyrazolo[4,3-b]pyridin-1-yl]acetamide; 240 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 241 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 242 N-Cyclopropyl-N-methyl-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 243 N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 244 N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4- fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]- N-methyl-acetamide; 245 N-Cyclopropyl-2-[3-methyl-6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 246 N-Cyclopropyl-2-[6-[3-(difluoromethoxy)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 247 N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 248 N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro- phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N- methyl-acetamide; 249 N-Cyclobutyl-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetamide; 250 N-(3,3-Difluorocyclobutyl)-2-[6-[3-(trifluoromethyl) phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 251 N-(3,3-Difluorocyclobutyl)-2-[6-[3-(difluoromethyl)- 4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 252 N-(3-Bicyclo[1.1.1]pentanyl)-2-[6-[3- (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b] pyridin-1-yl]-N-methyl-acetamide; 253 N-(Oxetan-3-yl)-2-[6-[3-(trifluoromethyl)phenyl] pyrazolo[4,3-b]pyridin-1-yl]acetamide; 254 2-(6-[3-(Difluoromethyl)-4-fluorophenyl)-1H- pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-3-yl) azetidin-1-yl)ethan-1-one; 255 2-(6-[3-(Difluoromethyl)-4-fluorophenyl)-1H- pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-2-yl) azetidin-1-yl)ethan-1-one; 256 Methyl (1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)- 3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl) azetidin-3-yl)carbamate; 257 (S)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)- 3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl) pyrrolidin-3-yl)acetamide; 258 (R)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)- 3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl) pyrrolidin-3-yl)acetamide; and 259 1-(3-(Fluoro-18F)azetidin-1-yl)-2-(6-(3-(trifluoromethyl) phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one; and pharmaceutically acceptable salts, N-oxides, or solvates thereof.

A further embodiment of the current invention is a compound selected from the group consisting of:

-   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;     and -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone;     and pharmaceutically acceptable salts, solvates, stereoisomers,     isotopic variants, or N-oxides thereof.     An additional embodiment of the invention is a pharmaceutical     composition comprising:

(A) an effective amount of at least one compound selected from compounds of Formula (I):

wherein

-   -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2;         and pharmaceutically acceptable salts, stereoisomers, isotopic         variants, N-oxides or solvates of compounds of Formula (I);

and (B) at least one pharmaceutically acceptable excipient.

An additional embodiment of the invention is a pharmaceutical composition comprising and effective amount of at least one compound of Formula (IA), as well as pharmaceutically acceptable salts, N-oxides or solvates of compounds of Formula (IA), pharmaceutically acceptable prodrugs of compounds of Formula (IA), and pharmaceutically active metabolites of Formula (IA); and at least one pharmaceutically acceptable excipient.

An additional embodiment of the invention is a pharmaceutical composition comprising and effective amount of at least one compound of Formula (IB), as well as pharmaceutically acceptable salts, N-oxides or solvates of compounds of Formula (IB), pharmaceutically acceptable prodrugs of compounds of Formula (IB), and pharmaceutically active metabolites of Formula (IB); and at least one pharmaceutically acceptable excipient.

An additional embodiment of the invention is a pharmaceutical composition comprising and effective amount of at least one compound of Formula (IC), as well as pharmaceutically acceptable salts, N-oxides or solvates of compounds of Formula (IC), pharmaceutically acceptable prodrugs of compounds of Formula (IC), and pharmaceutically active metabolites of Formula (IC); and at least one pharmaceutically acceptable excipient.

An additional embodiment of the invention is a pharmaceutical composition comprising and effective amount of at least one compound in Table 1, as well as pharmaceutically acceptable salts, N-oxides or solvates of compounds of Table 1, pharmaceutically acceptable prodrugs of compounds of Table 1, and pharmaceutically active metabolites of Table 1; and at least one pharmaceutically acceptable excipient.

Also within the scope of the invention are enantiomers and diastereomers of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)). Also within the scope of the invention are the pharmaceutically acceptable salts, N-oxides or solvates of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)). Also within the scope of the invention are the pharmaceutically acceptable prodrugs of compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), and pharmaceutically active metabolites of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)).

Also within the scope of the invention are isotopic variations of compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), such as, e.g., deuterated compounds of Formula (I). Also within the scope of the invention are the pharmaceutically acceptable salts, N-oxides or solvates of the isotopic variations of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)). Also within the scope of the invention are the pharmaceutically acceptable prodrugs of the isotopic variations of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), and pharmaceutically active metabolites of the isotopic variations of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)).

An additional embodiment of the invention is a method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by GluN2B receptor activity, comprising administering to a subject in need of such treatment an effective amount of at least one compound selected from compounds of Formula (I):

wherein

-   -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2;

    -   and pharmaceutically acceptable salts, stereoisomers, isotopic         variants, N-oxides, or solvates thereof, to a subject in need         thereof.

An additional embodiment of the invention is a method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by GluN2B receptor activity, comprising administering to a subject in need of such treatment an effective amount of at least one compound selected from compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), enantiomers and diastereomers of the compounds of Formula (I), isotopic variations of the compounds of Formula (I), and pharmaceutically acceptable salts of all of the foregoing.

In preferred embodiments of the inventive method, the disease, disorder, or medical condition is selected from: neurologic and psychiatric disorders including, but not limited to: (1) mood disorders and mood affective disorders; (2) neurotic, stress-related and somatoform disorders including anxiety disorders; (3) disorders of psychological development; (4) behavioral syndromes associated with physiological disturbances and physical factors; (5) extrapyramidal and movement disorders; (6) episodic and paroxysmal disorders, epilepsy; (7) pain; (8) forms of neurodegeneration; (9) cerebrovascular diseases, acute and chronic; and any sequelae of cerebrovascular diseases.

Examples of mood disorders and mood affective disorders that can be treated according to the present invention include, but are not limited to, bipolar disorder I depressed, hypomanic, manic and mixed form; bipolar disorder II; depressive disorders, such as single depressive episode or recurrent major depressive disorder, minor depressive disorder, treatment-resistant depression, depressive disorder with postpartum onset, depressive disorders with psychotic symptoms; persistent mood disorders, such as cyclothymia, dysthymia, euthymia; and premenstrual dysphoric disorder.

Examples of disorders belonging to the neurotic, stress-related and somatoform disorders that can be treated according to the present invention include, but are not limited to, anxiety disorders, general anxiety disorder, panic disorder with or without agoraphobia, specific phobia, social anxiety disorder, chronic anxiety disorders; obsessive compulsive disorder; reaction to sever stress and adjustment disorders, such as post-traumatic stress disorder (PTSD); other neurotic disorders such as depersonalisation-derealisation syndrome.

Examples of disorders of psychological development that can be treated according to the present invention include, but are not limited to pervasive developmental disorders, including but not limited to Asperger's syndrome and Rett's syndrome, autistic disorders, childhood autism and overactive disorder associated with mental retardation and stereotyped movements, specific developmental disorder of motor function, specific developmental disorders of scholastic skills.

Examples of behavioral syndromes associated with physiological disturbances and physical factors according to the present invention include, but are not limited to mental and behavioral disorders associated with childbirth, including but not limited to postnatal (postpartum) and prenatal depression; eating disorders, including but not limited to anorexia nervosa, bulimia nervosa, pica and binge eating disorder.

Examples of extrapyramidal and movement disorders that can be treated according to the present invention include, but are not limited to Parkinson's disease; second Parkinsonism, such as post encephalitic Parkinsonism; Parkinsonism comprised in other disorders; Lewis body disease; degenerative diseases of the basal ganglia; other extrapyramidal and movement disorders including but not limited to tremor, essential tremor and drug-induced tremor, myoclonus, chorea and drug-induced chorea, drug-induced tics and tics of organic origin, drug-induced acute dystonia, drug-induced tardive dyskinesia, L-dopa-induced dyskinesia; neuroleptic-induced movement disorders including but not limited to neuroleptic malignant syndrome (NMS), neuroleptic induced parkinsonism, neuroleptic-induced early onset or acute dyskinesia, neuroleptic-induced acute dystonia, neuroleptic-induced acute akathisia, neuroleptic-induced tardive dyskinesia, neuroleptic-induced tremor; restless leg syndrome, Stiff-man syndrome.

Further examples of movement disorders with malfunction and/or degeneration of basal ganglia that can be treated according to the present invention include, but are not limited to dystonia including but not limited to focal dystonia, multiple-focal or segmental dystonia, torsion dystonia, hemispheric, generalised and tardive dystonia (induced by psychopharmacological drugs). Focal dystonia include cervical dystonia (torticolli), blepharospasm (cramp of the eyelid), appendicular dystonia (cramp in the extremities, like the writer's cramp), oromandibular dystonia and spasmodic dysphonia (cramp of the vocal cord);

Examples for episodic and paroxysmal disorders that can be treated according to the present invention include, but are not limited to epilepsy, including localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, generalized idiopathic epilepsy and epileptic syndromes including but not limited to myoclonic epilepsy in infancy, neonatal convulsions (familial), childhood absence epilepsy (pyknolepsy), epilepsy with grand mal seizures on awakening, absence epilepsy, myoclonic epilepsy (impulsive petit mal) and nonspecific atonic, clonic, myoclonic, tonic, tonic-clonic epileptic seizures.

Further examples of epilepsy that can be treated according to the present invention include, but are not limited to epilepsy with myoclonic absences, myoclonic-astatic seizures, infantile spasms, Lennox-Gastaut syndrome, Salaam attacks, symptomatic early myoclonic encephalopathy, West's syndrome, petit and grand mal seizures; status epilepticus.

Examples of pain include, but are not limited to pain disorders related to psychological factors, such as persistent somatoform disorders; acute, chronic and chronic intractable pain, headache; acute and chronic pain related to physiological processes and physical disorders including but not limited to back pain, tooth pain, abdominal pain, low back pain, pain in joints; acute and chronic pain that is related to diseases of the musculoskeletal system and connective tissue including, but not limited to rheumatism, myalgia, neuralgia and fibromyalgia; acute and chronic pain that is related to nerve, nerve root and plexus disorders, such as trigeminal pain, postzoster neuralgia, phantom limb syndrome with pain, carpal tunnel syndrome, lesion of sciatic nerve, diabetic mononeuropathy; acute and chronic pain that is related to polyneuropathies and other disorders of the peripheral nervous system, such as hereditary and idiopathic neuropathy, inflammatory polyneuropathy, polyneuropathy induced by drugs, alcohol or toxic agents, polyneuropathy in neoplastic disease, diabetic polyneuropathy.

Examples of diseases that include forms of neurodegeneration include, but are not limited to, acute neurodegeneration, such as intracranial brain injuries, such as stroke, diffuse and local brain injuries, epidural, subdural and subarachnoid haemorrhage, and chronic neurodegeneration, such as Alzheimer's disease, Huntington's disease, multiple sclerosis and ALS.

Examples of cerebrovascular diseases include, but are not limited to, subarachnoid haemorrhage, intracerebral haemorrhage and other nontraumatic intracranial haemorrhage, cerebral infarction, stroke, occlusion and stenosis or precerebral and cerebral arteries, not resulting in cerebral infarction, dissection of cerebral arteries, cerebral aneurysm, cerebral atherosclerosis, progressive vascular leukoencephalopathy, hypertensive encephalopathy, nonpyogenic thrombosis of intracranial venous system, cerebral arteritis, cerebral amyloid angiopathy and sequelae of cerebrovascular diseases.

In some embodiments, administration of a compound of the invention, or pharmaceutically acceptable salt thereof, is effective in preventing the disease; for example, preventing a disease, condition or disorder in an individual who may be predisposed to the disease, condition or disorder but does not yet experience or display the pathology or symptomatology of the disease.

Additional embodiments, features, and advantages of the invention will be apparent from the following detailed description and through practice of the invention.

The invention may be more fully appreciated by reference to the following description, including the following glossary of terms and the concluding examples. For the sake of brevity, the disclosures of the publications, including patents, cited in this specification are herein incorporated by reference.

As used herein, the terms “including”, “containing” and “comprising” are used herein in their open, non-limiting sense.

The term “alkyl” refers to a straight- or branched-chain alkyl group having from 1 to 12 carbon atoms in the chain. Examples of alkyl groups include methyl (Me, which also may be structurally depicted by the symbol, “/”), ethyl (Et), n-propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl (tBu), pentyl, isopentyl, tert-pentyl, hexyl, isohexyl, and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples. The term C₁₋₆alkyl as used here refers to a straight- or branched-chain alkyl group having from 1 to 4 carbon atoms in the chain. The term C₁₋₆alkyl as used here refers to a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms in the chain.

The term “halo” represents chloro, fluoro, bromo or iodo.

The term “perhaloalkyl” or “haloalkyl” refers to a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms in the chain optionally substituting hydrogens with halogens. The term “C₁₋₃perhaloalkyl” as used here refers to a straight- or branched-chain alkyl group having from 1 to 3 carbon atoms in the chain, optionally substituting hydrogens with halogens. The term “C₁₋₆perhaloalkyl” as used here refers to a straight- or branched-chain alkyl group having from 1 to 6 carbon atoms in the chain, optionally substituting hydrogens with halogens. Examples of “perhaloalkyl”, “haloalkyl” groups include trifluoromethyl (CF₃), difluoromethyl (CF₂H), monofluoromethyl (CH₂F), pentafluoroethyl (CF₂CF₃), tetrafluoroethyl (CHFCF₃), monofluoroethyl (CH₂CH₂F), trifluoroethyl (CH₂CF₃), tetrafluorotrifluoromethylethyl (CF(CF₃)₂), chloropropyl (CH₂CH₂CH₂Cl), and groups that in light of the ordinary skill in the art and the teachings provided herein would be considered equivalent to any one of the foregoing examples.

The term “alkoxy” includes a straight chain or branched alkyl group with a terminal oxygen linking the alkyl group to the rest of the molecule. Alkoxy includes methoxy, ethoxy, propoxy, isopropoxy, butoxy, t-butoxy, pentoxy and so on.

The term “cyano” refers to the group —CN.

The term “aryl” refers to a monocyclic, aromatic carbocycle (ring structure having ring atoms that are all carbon) having 6 atoms per ring. (Carbon atoms in the aryl groups are sp² hybridized.)

The term “phenyl” represents the following moiety:

The term “thienyl” represents the following moiety:

The term “heteroaryl” refers to a monocyclic or fused bicyclic heterocycle (ring structure having ring atoms selected from carbon atoms and up to four heteroatoms selected from nitrogen, oxygen, and sulfur) having from 3 to 9 ring atoms per heterocycle. Illustrative examples of heteroaryl groups include the following entities, in the form of properly bonded moieties:

Those skilled in the art will recognize that the species of heteroaryl, cycloalkyl, aryl and heterocycloalkyl groups listed or illustrated above are not exhaustive, and that additional species within the scope of these defined terms may also be selected.

A “heterocycloalkyl” refers to a monocyclic, bicyclic (fused or spirocyclic) ring structure that is saturated or partially saturated and has from 4 to 7 ring atoms per ring structure selected from carbon atoms and up to two heteroatoms selected from nitrogen, oxygen, and sulfur. The ring structure may optionally contain up to two oxo groups on sulfur ring members. Illustrative entities, in the form of properly bonded moieties, include:

The term “cycloalkyl” refers to a saturated or partially saturated, monocyclic, fused polycyclic, or spiro polycyclic carbocycle having from 3 to 12 ring atoms per carbocycle. Illustrative examples of cycloalkyl groups include the following entities, in the form of properly bonded moieties:

The term “pyridinyl” or “pyridyl” represents the following moiety:

The pyridinyl or pyridyl moiety can be attached through any one of the 2-, 3-, 4-, 5-, or 6-position carbon atoms.

The term “pyrimidinyl” represents the following moiety:

The pyrimidinyl moiety can be attached through any one of the 2-, 4-, 5-, or 6-position carbon atoms.

The term “imidazolyl” represents the following moiety:

The imidazolyl moiety can be attached through any one of the 1-, 2-, 3-, 4-, or 5-position carbon atoms.

The term “piperidinyl” represents the following moiety:

When the piperidinyl moiety is a substituent, it can be attached through any one of the 1-, 2-, 3-, 4-, 5-, or 6-position atoms, as permitted.

The term “pyrrolidinyl” represents the following moiety:

When the piperidinyl moiety is a substituent, it can be attached through any one of the 1-, 2-, 3-, 4-, or 5-position atoms, as permitted.

The term “azetidinyl” represents a 4-membered heterocycloalkyl moiety having one ring nitrogen. When the azetidinyl moiety is a substituent, it can be attached through any carbon atom or through the nitrogen atom, as permitted.

The term “morpholinyl” represents the following moiety:

When the morpholinyl moiety is a substituent, it can be attached through any one of the 2-, 3-4-, 5-, or 6-position atoms, as permitted.

The term “substituted” means that the specified group or moiety bears one or more substituents. The term “unsubstituted” means that the specified group bears no substituents. The term “optionally substituted” means that the specified group is unsubstituted or substituted by one or more substituents. Where the term “substituted” is used to describe a structural system, the substitution is meant to occur at any valency-allowed position on the system. In cases where a specified moiety or group is not expressly noted as being optionally substituted or substituted with any specified substituent, it is understood that such a moiety or group is intended to be unsubstituted.

The terms “para”, “meta”, and “ortho” have the meanings as understood in the art. Thus, for example, a fully substituted phenyl group has substituents at both “ortho” (o) positions adjacent to the point of attachment of the phenyl ring, both “meta” (m) positions, and the one “para” (p) position across from the point of attachment. To further clarify the position of substituents on the phenyl ring, the 2 different ortho positions will be designated as ortho and ortho' and the 2 different meta positions as meta and meta' as illustrated below.

When referring to substituents on a pyridyl group, the terms “para”, “meta”, and “ortho” refer to the placement of a substituent relative to the point of attachment of the pyridyl ring. For example the structure below is described as 3-pyridyl with the X¹ substituent in the ortho position, the X² substituent in the meta position, and X³ substituent in the para position:

To provide a more concise description, some of the quantitative expressions given herein are not qualified with the term “about”. It is understood that, whether the term “about” is used explicitly or not, every quantity given herein is meant to refer to the actual given value, and it is also meant to refer to the approximation to such given value that would reasonably be inferred based on the ordinary skill in the art, including equivalents and approximations due to the experimental and/or measurement conditions for such given value. Whenever a yield is given as a percentage, such yield refers to a mass of the entity for which the yield is given with respect to the maximum amount of the same entity that could be obtained under the particular stoichiometric conditions. Concentrations that are given as percentages refer to mass ratios, unless indicated differently.

The terms “buffered” solution or “buffer” solution are used herein interchangeably according to their standard meaning. Buffered solutions are used to control the pH of a medium, and their choice, use, and function is known to those of ordinary skill in the art. See, for example, G. D. Considine, ed., Van Nostrand's Encyclopedia of Chemistry, p. 261, 5^(th) ed. (2005), describing, inter alia, buffer solutions and how the concentrations of the buffer constituents relate to the pH of the buffer. For example, a buffered solution is obtained by adding MgSO₄ and NaHCO₃ to a solution in a 10:1 w/w ratio to maintain the pH of the solution at about 7.5.

Any formula given herein is intended to represent compounds having structures depicted by the structural formula as well as certain variations or forms. In particular, compounds of any formula given herein may have asymmetric centers and therefore exist in different enantiomeric forms. All optical isomers of the compounds of the general formula, and mixtures thereof, are considered within the scope of the formula. Thus, any formula given herein is intended to represent a racemate, one or more enantiomeric forms, one or more diastereomeric forms, one or more atropisomeric forms, and mixtures thereof. Furthermore, certain structures may exist as geometric isomers (i.e., cis and trans isomers), as tautomers, or as atropisomers.

It is also to be understood that compounds that have the same molecular formula but differ in the nature or sequence of bonding of their atoms or the arrangement of their atoms in space are termed “isomers.” Isomers that differ in the arrangement of their atoms in space are termed “.”

Stereoisomers that are not mirror images of one another are termed “diastereomers” and those that are non-superimposable mirror images of each other are termed “enantiomers.” When a compound has an asymmetric center, for example, it is bonded to four different groups, and a pair of enantiomers is possible. An enantiomer can be characterized by the absolute configuration of its asymmetric center and is described by the R- and S-sequencing rules of Cahn and Prelog, or by the manner in which the molecule rotates the plane of polarized light and designated as dextrorotatory or levorotatory (i.e., as (+)- or (−)-isomers respectively). A chiral compound can exist as either an individual enantiomer or as a mixture thereof. A mixture containing equal proportions of the enantiomers is called a “racemic mixture.”

“Tautomers” refer to compounds that are interchangeable forms of a particular compound structure, and that vary in the displacement of hydrogen atoms and electrons. Thus, two structures may be in equilibrium through the movement of π electrons and an atom (usually H). For example, enols and ketones are tautomers because they are rapidly interconverted by treatment with either acid or base. Another example of tautomerism is the aci- and nitro-forms of phenyl nitromethane, that are likewise formed by treatment with acid or base.

Tautomeric forms may be relevant to the attainment of the optimal chemical reactivity and biological activity of a compound of interest.

The compounds of this invention may possess one or more asymmetric centers; such compounds can therefore be produced as individual (R)- or (S)-stereoisomers or as mixtures thereof.

Unless indicated otherwise, the description or naming of a particular compound in the specification and claims is intended to include both individual enantiomers and mixtures, racemic or otherwise, thereof. The methods for the determination of stereochemistry and the separation of stereoisomers are well-known in the art.

Certain examples contain chemical structures that are depicted as an absolute enantiomer but are intended to indicate enantiopure material that is of unknown configuration. In these cases (R*) or (S*) is used in the name to indicate that the absolute stereochemistry of the corresponding stereocenter is unknown. Thus, a compound designated as (R*) refers to an enantiopure compound with an absolute configuration of either (R) or (S). In cases where the absolute stereochemistry has been confirmed, the structures are named using (R) and (S).

The symbols

and

are used as meaning the same spatial arrangement in chemical structures shown herein. Analogously, the symbols

and

are used as meaning the same spatial arrangement in chemical structures shown herein.

Additionally, any formula given herein is intended to refer also to hydrates, solvates, and polymorphs of such compounds, and mixtures thereof, even if such forms are not listed explicitly. Certain compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), or pharmaceutically acceptable salts of compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)) may be obtained as solvates. Solvates include those formed from the interaction or complexation of compounds of the invention with one or more solvents, either in solution or as a solid or crystalline form. In some embodiments, the solvent is water and the solvates are hydrates. In addition, certain crystalline forms of compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)) or pharmaceutically acceptable salts of compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)) may be obtained as co-crystals. In certain embodiments of the invention, compounds of Formula (I) were obtained in a crystalline form. In other embodiments, crystalline forms of compounds of Formula (I) were cubic in nature. In other embodiments, pharmaceutically acceptable salts of compounds of Formula (I) were obtained in a crystalline form. In still other embodiments, compounds of Formula (I) were obtained in one of several polymorphic forms, as a mixture of crystalline forms, as a polymorphic form, or as an amorphous form. In other embodiments, compounds of Formula (I) convert in solution between one or more crystalline forms and/or polymorphic forms.

Reference to a compound herein stands for a reference to any one of: (a) the actually recited form of such compound, and (b) any of the forms of such compound in the medium in which the compound is being considered when named. For example, reference herein to a compound such as R—COOH, encompasses reference to any one of, for example, R—COOH_((s)), R—COOH_((sol)), and R—COO⁻ _((sol)). In this example, R—COOH_((s)) refers to the solid compound, as it could be for example in a tablet or some other solid pharmaceutical composition or preparation; R—COOH_((sol)) refers to the undissociated form of the compound in a solvent; and R—COO⁻ _((sol)) refers to the dissociated form of the compound in a solvent, such as the dissociated form of the compound in an aqueous environment, whether such dissociated form derives from R—COOH, from a salt thereof, or from any other entity that yields R—COO⁻ upon dissociation in the medium being considered. In another example, an expression such as “exposing an entity to compound of formula R—COOH” refers to the exposure of such entity to the form, or forms, of the compound R—COOH that exists, or exist, in the medium in which such exposure takes place. In still another example, an expression such as “reacting an entity with a compound of formula R—COOH” refers to the reacting of (a) such entity in the chemically relevant form, or forms, of such entity that exists, or exist, in the medium in which such reacting takes place, with (b) the chemically relevant form, or forms, of the compound R—COOH that exists, or exist, in the medium in which such reacting takes place. In this regard, if such entity is for example in an aqueous environment, it is understood that the compound R—COOH is in such same medium, and therefore the entity is being exposed to species such as R—COOH_((aq)) and/or R—COO⁻ _((aq)), where the subscript “(aq)” stands for “aqueous” according to its conventional meaning in chemistry and biochemistry. A carboxylic acid functional group has been chosen in these nomenclature examples; this choice is not intended, however, as a limitation but it is merely an illustration. It is understood that analogous examples can be provided in terms of other functional groups, including but not limited to hydroxyl, basic nitrogen members, such as those in amines, and any other group that interacts or transforms according to known manners in the medium that contains the compound. Such interactions and transformations include, but are not limited to, dissociation, association, tautomerism, solvolysis, including hydrolysis, solvation, including hydration, protonation, and deprotonation. No further examples in this regard are provided herein because these interactions and transformations in a given medium are known by any one of ordinary skill in the art.

In another example, a zwitterionic compound is encompassed herein by referring to a compound that is known to form a zwitterion, even if it is not explicitly named in its zwitterionic form. Terms such as zwitterion, zwitterions, and their synonyms zwitterionic compound(s) are standard IUPAC-endorsed names that are well known and part of standard sets of defined scientific names. In this regard, the name zwitterion is assigned the name identification CHEBI:27369 by the Chemical Entities of Biological Interest (ChEBI) dictionary of molecular entities. As generally well known, a zwitterion or zwitterionic compound is a neutral compound that has formal unit charges of opposite sign. Sometimes these compounds are referred to by the term “inner salts”. Other sources refer to these compounds as “dipolar ions”, although the latter term is regarded by still other sources as a misnomer. As a specific example, aminoethanoic acid (the amino acid glycine) has the formula H₂NCH₂COOH, and it exists in some media (in this case in neutral media) in the form of the zwitterion ⁺H₃NCH₂COO⁻. Zwitterions, zwitterionic compounds, inner salts and dipolar ions in the known and well established meanings of these terms are within the scope of this invention, as would in any case be so appreciated by those of ordinary skill in the art. Because there is no need to name each and every embodiment that would be recognized by those of ordinary skill in the art, no structures of the zwitterionic compounds that are associated with the compounds of this invention are given explicitly herein. They are, however, part of the embodiments of this invention. No further examples in this regard are provided herein because the interactions and transformations in a given medium that lead to the various forms of a given compound are known by any one of ordinary skill in the art.

Any formula given herein is also intended to represent unlabeled forms as well as isotopically labeled forms of the compounds. Isotopically labeled compounds have structures depicted by the formulas given herein except that one or more atoms are replaced by an atom having a selected atomic mass or mass number. Examples of isotopes that can be incorporated into compounds of the invention include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorus, sulfur, fluorine, chlorine, and iodine such as ²H, ³H, ¹¹C, ¹³C, ¹⁴C, ¹⁵N, ¹⁸O, ¹⁷O, ³¹P, ³²P, ³⁵S, ¹⁸F, ³⁶Cl, ¹²⁵I, respectively. Such isotopically labeled compounds are useful in metabolic studies (preferably with ³C), reaction kinetic studies (with, for example deuterium (i.e., D or ²H); or tritium (i.e., T or ³H)), detection or imaging techniques [such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT)] including drug or substrate tissue distribution assays, or in radioactive treatment of patients. In particular, an ¹⁸F or ¹¹C labeled compound may be particularly preferred for PET or SPECT studies. Further, substitution with heavier isotopes such as deuterium (i.e., ²H) may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life or reduced dosage requirements. Isotopically labeled compounds of this invention and prodrugs thereof can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by using a readily available isotopically labeled reagent for a non-isotopically labeled reagent.

When referring to any formula given herein, the selection of a particular moiety from a list of possible species for a specified variable is not intended to define the same choice of the species for the variable appearing elsewhere. In other words, where a variable appears more than once, the choice of the species from a specified list is independent of the choice of the species for the same variable elsewhere in the formula, unless stated otherwise.

According to the foregoing interpretive considerations on assignments and nomenclature, it is understood that explicit reference herein to a set implies, where chemically meaningful and unless indicated otherwise, independent reference to embodiments of such set, and reference to each and every one of the possible embodiments of subsets of the set referred to explicitly.

By way of a first example on substituent terminology, if substituent S¹ _(example) is one of S₁ and S₂, and substituent S² _(example) is one of S₃ and S₄, then these assignments refer to embodiments of this invention given according to the choices S¹ _(example) is S₁ and S² _(example) is S₃; S¹ _(example) is S₁ and S² _(example) is S₄; S¹ _(example) is S₂ and S² _(example) is S₃; S¹ _(example) is S₂ and S² _(example) is S₄; and equivalents of each one of such choices. The shorter terminology “S¹ _(example) is one of S₁ and S₂, and S² _(example) is one of S₃ and S₄” is accordingly used herein for the sake of brevity, but not by way of limitation. The foregoing first example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent assignments described herein. The foregoing convention given herein for substituents extends, when applicable, to members such as R¹, R², R^(a), R^(b), R^(d), R^(e) Ar¹, n, m, X, and ring A, and any other generic substituent symbol used herein.

Furthermore, when more than one assignment is given for any member or substituent, embodiments of this invention comprise the various groupings that can be made from the listed assignments, taken independently, and equivalents thereof. By way of a second example on substituent terminology, if it is herein described that substituent S_(example) is one of S₁, S₂, and S₃, this listing refers to embodiments of this invention for which S_(example) is S₁; S_(example) is S₂; S_(example) is S₃; S_(example) is one of S₁ and S₂; S_(example) is one of S₁ and S₃; S_(example) is one of S₂ and S₃; S_(example) is one of S₁, S₂ and S₃; and S_(example) is any equivalent of each one of these choices. The shorter terminology “S_(example) is one of S₁, S₂, and S₃” is accordingly used herein for the sake of brevity, but not by way of limitation. The foregoing second example on substituent terminology, which is stated in generic terms, is meant to illustrate the various substituent assignments described herein. The foregoing convention given herein for substituents extends, when applicable, to members such as R¹, R², R^(a), R^(b), R^(d), R^(e) Ar¹, n, m, X, and ring A, and any other generic substituent symbol used herein.

The nomenclature “C_(i-j)” with j>i, when applied herein to a class of substituents, is meant to refer to embodiments of this invention for which each and every one of the number of carbon members, from i to j including i and j, is independently realized. By way of example, the term C₁₋₆ refers independently to embodiments that have one carbon member (C₁), embodiments that have two carbon members (C₂), embodiments that have three carbon members (C₃), and embodiments that have four carbon members (C₄).

The term C_(n-m)alkyl refers to an aliphatic chain, whether straight or branched, with a total number N of carbon members in the chain that satisfies n≤N≤m, with m>n. Any disubstituent referred to herein is meant to encompass the various attachment possibilities when more than one of such possibilities are allowed. For example, reference to disubstituent -A-B—, where A≠B, refers herein to such disubstituent with A attached to a first substituted member and B attached to a second substituted member, and it also refers to such disubstituent with A attached to the second substituted member and B attached to the first substituted member.

The invention includes also pharmaceutically acceptable salts of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), preferably of those described above and of the specific compounds exemplified herein, and methods of treatment using such salts.

The term “pharmaceutically acceptable” means approved or approvable by a regulatory agency of Federal or a state government or the corresponding agency in countries other than the United States, or that is listed in the U. S. Pharmacopeia or other generally recognized pharmacopoeia for use in animals, and more particularly, in humans.

A “pharmaceutically acceptable salt” is intended to mean a salt of a free acid or base of compounds represented by Formula (I) (as well as Formulas (IA), (IB), and (IC)) that are non-toxic, biologically tolerable, or otherwise biologically suitable for administration to the subject. It should possess the desired pharmacological activity of the parent compound. See, generally, G. S. Paulekuhn, et al., “Trends in Active Pharmaceutical Ingredient Salt Selection based on Analysis of the Orange Book Database”, J. Med. Chem., 2007, 50:6665-72, S. M. Berge, et al., “Pharmaceutical Salts”, J Pharm Sci., 1977, 66:1-19, and Handbook of Pharmaceutical Salts, Properties, Selection, and Use, Stahl and Wermuth, Eds., Wiley-VCH and VHCA, Zurich, 2002. Examples of pharmaceutically acceptable salts are those that are pharmacologically effective and suitable for contact with the tissues of patients without undue toxicity, irritation, or allergic response. A compound of Formula (I) (as well as Formulas (IA), (IB), and (IC)) may possess a sufficiently acidic group, a sufficiently basic group, or both types of functional groups, and accordingly react with a number of inorganic or organic bases, and inorganic and organic acids, to form a pharmaceutically acceptable salt.

Examples of pharmaceutically acceptable salts include sulfates, pyrosulfates, bisulfates, sulfites, bisulfites, phosphates, monohydrogen-phosphates, dihydrogenphosphates, metaphosphates, pyrophosphates, chlorides, bromides, iodides, acetates, propionates, decanoates, caprylates, acrylates, formates, isobutyrates, caproates, heptanoates, propiolates, oxalates, malonates, succinates, suberates, sebacates, fumarates, maleates, butyne-1,4-dioates, hexyne-1,6-dioates, benzoates, chlorobenzoates, methylbenzoates, dinitrobenzoates, hydroxybenzoates, methoxybenzoates, phthalates, sulfonates, xylenesulfonates, phenylacetates, phenylpropionates, phenylbutyrates, citrates, lactates, γ-hydroxybutyrates, glycolates, tartrates, methane-sulfonates, propanesulfonates, naphthalene-1-sulfonates, naphthalene-2-sulfonates, and mandelates.

When the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)) contain a basic nitrogen, the desired pharmaceutically acceptable salt may be prepared by any suitable method available in the art. For example, treatment of the free base with an inorganic acid, such as hydrochloric acid, hydrobromic acid, sulfuric acid, sulfamic acid, nitric acid, boric acid, phosphoric acid, and the like, or with an organic acid, such as acetic acid, phenylacetic acid, propionic acid, stearic acid, lactic acid, ascorbic acid, maleic acid, hydroxymaleic acid, isethionic acid, succinic acid, valeric acid, fumaric acid, malonic acid, pyruvic acid, oxalic acid, glycolic acid, salicylic acid, oleic acid, palmitic acid, lauric acid, a pyranosidyl acid, such as glucuronic acid or galacturonic acid, an alpha-hydroxy acid, such as mandelic acid, citric acid, or tartaric acid, an amino acid, such as aspartic acid, glutaric acid or glutamic acid, an aromatic acid, such as benzoic acid, 2-acetoxybenzoic acid, naphthoic acid, or cinnamic acid, a sulfonic acid, such as laurylsulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, ethanesulfonic acid, any compatible mixture of acids such as those given as examples herein, and any other acid and mixture thereof that are regarded as equivalents or acceptable substitutes in light of the ordinary level of skill in this technology.

When the compound of Formula (I) (as well as Formulas (IA), (IB), and (IC)) is an acid, such as a carboxylic acid or sulfonic acid, the desired pharmaceutically acceptable salt may be prepared by any suitable method, for example, treatment of the free acid with an inorganic or organic base, such as an amine (primary, secondary or tertiary), an alkali metal hydroxide, alkaline earth metal hydroxide, any compatible mixture of bases such as those given as examples herein, and any other base and mixture thereof that are regarded as equivalents or acceptable substitutes in light of the ordinary level of skill in this technology. Illustrative examples of suitable salts include organic salts derived from amino acids, such as N-methyl-D-glucamine, lysine, choline, glycine and arginine, ammonia, carbonates, bicarbonates, primary, secondary, and tertiary amines, and cyclic amines, such as tromethamine, benzylamines, pyrrolidines, piperidine, morpholine, and piperazine, and inorganic salts derived from sodium, calcium, potassium, magnesium, manganese, iron, copper, zinc, aluminum, and lithium.

The invention also relates to pharmaceutically acceptable prodrugs of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), and treatment methods employing such pharmaceutically acceptable prodrugs. The term “prodrug” means a precursor of a designated compound that, following administration to a subject, yields the compound in vivo via a chemical or physiological process such as solvolysis or enzymatic cleavage, or under physiological conditions (e.g., a prodrug on being brought to physiological pH is converted to the compound of Formula (I). A “pharmaceutically acceptable prodrug” is a prodrug that is non-toxic, biologically tolerable, and otherwise biologically suitable for administration to the subject. Illustrative procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in “Design of Prodrugs”, ed. H. Bundgaard, Elsevier, 1985.

Exemplary prodrugs include compounds having an amino acid residue, or a polypeptide chain of two or more (e.g., two, three or four) amino acid residues, covalently joined through an amide or ester bond to a free amino, hydroxyl, or carboxylic acid group of a compound of Formula (I) (as well as Formulas (IA), (IB), and (IC)). Examples of amino acid residues include the twenty naturally occurring amino acids, commonly designated by three letter symbols, as well as 4-hydroxyproline, hydroxylysine, demosine, isodemosine, 3-methylhistidine, norvalin, beta-alanine, gamma-aminobutyric acid, citrulline homocysteine, homoserine, ornithine and methionine sulfone.

Additional types of prodrugs may be produced, for instance, by derivatizing free carboxyl groups of structures of Formula (I) (as well as Formulas (IA), (IB), and (IC)) as amides or alkyl esters. Examples of amides include those derived from ammonia, primary C₁₋₆alkyl amines and secondary di(C₁₋₆alkyl) amines. Secondary amines include 5- or 6-membered heterocycloalkyl or heteroaryl ring moieties. Examples of amides include those that are derived from ammonia, C₁₋₃alkyl primary amines, and di(C₁₋₂alkyl)amines. Examples of esters of the invention include C₁₋₇alkyl, C₅-7cycloalkyl, phenyl, and phenyl(C₁₋₆alkyl) esters. Preferred esters include methyl esters. Prodrugs may also be prepared by derivatizing free hydroxy groups using groups including hemisuccinates, phosphate esters, dimethylaminoacetates, and phosphoryloxymethyloxycarbonyls, following procedures such as those outlined in Fleisher et al., Adv. Drug Delivery Rev. 1996, 19, 115-130. Carbamate derivatives of hydroxy and amino groups may also yield prodrugs. Carbonate derivatives, sulfonate esters, and sulfate esters of hydroxy groups may also provide prodrugs. Derivatization of hydroxy groups as (acyloxy)methyl and (acyloxy)ethyl ethers, wherein the acyl group may be an alkyl ester, optionally substituted with one or more ether, amine, or carboxylic acid functionalities, or where the acyl group is an amino acid ester as described above, is also useful to yield prodrugs. Prodrugs of this type may be prepared as described in Robinson et al., J Med Chem. 1996, 39 (1), 10-18. Free amines can also be derivatized as amides, sulfonamides or phosphonamides. All of these prodrug moieties may incorporate groups including ether, amine, and carboxylic acid functionalities.

The present invention also relates to pharmaceutically active metabolites of the compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)), which may also be used in the methods of the invention. A “pharmaceutically active metabolite” means a pharmacologically active product of metabolism in the body of a compound of Formula (I) (as well as Formulas (IA), (IB), and (IC) as applicable) or salt thereof. Prodrugs and active metabolites of a compound may be determined using routine techniques known or available in the art. See, e.g., Bertolini, et al., J Med Chem. 1997, 40, 2011-2016; Shan, et al., J Pharm Sci. 1997, 86 (7), 765-767; Bagshawe, Drug Dev Res. 1995, 34, 220-230; Bodor, Adv Drug Res. 1984, 13, 224-331; Bundgaard, Design of Prodrugs (Elsevier Press, 1985); and Larsen, Design and Application of Prodrugs, Drug Design and Development (Krogsgaard-Larsen, et al., eds., Harwood Academic Publishers, 1991).

The compounds of Formula (I) (as well as Formulas (IA), (IB), and (IC)) and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, and pharmaceutically active metabolites of the present invention are useful as modulators of the GluN2B receptor in the methods of the invention. As such modulators, the compounds may act as antagonists, agonists, or inverse agonists. The term “modulators” include both inhibitors and activators, where “inhibitors” refer to compounds that decrease, prevent, inactivate, desensitize, or down-regulate the GluN2B receptor expression or activity, and “activators” are compounds that increase, activate, facilitate, sensitize, or up-regulate GluN2B receptor expression or activity.

The term “treat”, “treatment” or “treating”, as used herein, is intended to refer to administration of an active agent or composition of the invention to a subject for the purpose of affecting a therapeutic or prophylactic benefit through modulation of GluN2B receptor activity. Treating includes reversing, ameliorating, alleviating, inhibiting the progress of, lessening the severity of, or preventing a disease, disorder, or condition, or one or more symptoms of such disease, disorder or condition mediated through modulation of GluN2B receptor activity. The term “subject” refers to a mammalian patient in need of such treatment, such as a human.

Accordingly, the invention relates to methods of using the compounds described herein to treat subjects diagnosed with or suffering from a disease, disorder, or condition mediated by GluN2B receptor activity, such as: bipolar disorder I depressed, hypomanic, manic and mixed form; bipolar disorder II; depressive disorders, such as single depressive episode or recurrent major depressive disorder, minor depressive disorder, treatment-resistant depression, depressive disorder with postpartum onset, disruptive mood dysregulation disorder, depressive disorders with psychotic symptoms; persistent mood disorders, such as cyclothymia, dysthymia, euthymia; and premenstrual dysphoric disorder; anxiety disorders, general anxiety disorder, panic disorder with or without agoraphobia, specific phobia, social anxiety disorder, chronic anxiety disorders; obsessive compulsive disorder; reaction to sever stress and adjustment disorders, such as post-traumatic stress disorder (PTSD); other neurotic disorders such as depersonalisation-derealisation syndrome; pervasive developmental disorders, including but not limited to Asperger's syndrome and Rett's syndrome, autistic disorders, childhood autism and overactive disorder associated with mental retardation and stereotyped movements, specific developmental disorder of motor function, specific developmental disorders of scholastic skills; postnatal (postpartum) and prenatal depression; eating disorders, including but not limited to anorexia nervosa, bulimia nervosa, pica and binge eating disorder; Parkinson's disease; second Parkinsonism, such as post encephalitic Parkinsonism; Parkinsonism comprised in other disorders; Lewis body disease; degenerative diseases of the basal ganglia; other extrapyramidal and movement disorders including but not limited to tremor, essential tremor and drug-induced tremor, myoclonus, chorea and drug-induced chorea, drug-induced tics and tics of organic origin, drug-induced acute dystonia, drug-induced tardive dyskinesia, L-dopa-induced dyskinesia; neuroleptic-induced movement disorders including but not limited to neuroleptic malignant syndrome (NMS), neuroleptic induced parkinsonism, neuroleptic-induced early onset or acute dyskinesia, neuroleptic-induced acute dystonia, neuroleptic-induced acute akathisia, neuroleptic-induced tardive dyskinesia, neuroleptic-induced tremor; restless leg syndrome, Stiff-man syndrome; dystonia including but not limited to focal dystonia, multiple-focal or segmental dystonia, torsion dystonia, hemispheric, generalized and tardive dystonia (induced by psychopharmacological drugs). Focal dystonia include cervical dystonia (torticolli), blepharospasm (cramp of the eyelid), appendicular dystonia (cramp in the extremities, like the writer's cramp), oromandibular dystonia and spasmodic dysphonia (cramp of the vocal cord); epilepsy, including localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, generalized idiopathic epilepsy and epileptic syndromes including but not limited to myoclonic epilepsy in infancy, neonatal convulsions (familial), childhood absence epilepsy (pyknolepsy), epilepsy with grand mal seizures on awakening, absence epilepsy, myoclonic epilepsy (impulsive petit mal) and nonspecific atonic, clonic, myoclonic, tonic, tonic-clonic epileptic seizures; epilepsy with myoclonic absences, myoclonic-astatic seizures, infantile spasms, Lennox-Gastaut syndrome, Salaam attacks, symptomatic early myoclonic encephalopathy, West's syndrome, petit and grand mal seizures; status epilepticus; persistent somatoform disorders; acute, chronic and chronic intractable pain, headache; acute and chronic pain related to physiological processes and physical disorders including but not limited to back pain, tooth pain, abdominal pain, low back pain, pain in joints; acute and chronic pain that is related to diseases of the musculoskeletal system and connective tissue including, but not limited to rheumatism, myalgia, neuralgia and fibromyalgia; acute and chronic pain that is related to nerve, nerve root and plexus disorders, such as trigeminal pain, postzoster neuralgia, phantom limb syndrome with pain, carpal tunnel syndrome, lesion of sciatic nerve, diabetic mononeuropathy; acute and chronic pain that is related to polyneuropathies and other disorders of the peripheral nervous system, such as hereditary and idiopathic neuropathy, inflammatory polyneuropathy, polyneuropathy induced by drugs, alcohol or toxic agents, polyneuropathy in neoplastic disease, diabetic polyneuropathy; and acute neurodegeneration, such as intracranial brain injuries, such as stroke, diffuse and local brain injuries, epidural, subdural and subarachnoid haemorrhage, and chronic neurodegeneration, such as Alzheimer's disease, Huntington's disease, multiple sclerosis, and ALS; subarachnoid haemorrhage, intracerebral haemorrhage and other nontraumatic intracranial haemorrhage, cerebral infarction, stroke, occlusion and stenosis or precerebral and cerebral arteries, not resulting in cerebral infarction, dissection of cerebral arteries, cerebral aneurysm, cerebral atherosclerosis, progressive vascular leukoencephalopathy, hypertensive encephalopathy, nonpyogenic thrombosis of intracranial venous system, cerebral arteritis, cerebral amyloid angiopathy and sequelae of cerebrovascular diseases; glaucoma and other neuropathies; dementias, vascular dementia, Lewy body dementia, frontotemporal dementia, and HIV-dementia; vertigo and nystagmus; tinnitus; neuropsychiatric systemic lupus erythematosus; disruptive mood dysregulation disorder; schizophrenia spectrum disorder; and sleep/wake disorders.

In treatment methods according to the invention, an effective amount of a pharmaceutical agent according to the invention is administered to a subject suffering from or diagnosed as having such a disease, disorder, or condition. An “effective amount” means an amount or dose sufficient to generally bring about the desired therapeutic or prophylactic benefit in patients in need of such treatment for the designated disease, disorder, or condition. Effective amounts or doses of the compounds of the present invention may be ascertained by routine methods such as modeling, dose escalation studies or clinical trials, and by taking into consideration routine factors, e.g., the mode or route of administration or drug delivery, the pharmacokinetics of the compound, the severity and course of the disease, disorder, or condition, the subject's previous or ongoing therapy, the subject's health status and response to drugs, and the judgment of the treating physician. An example of a dose is in the range of from about 0.001 to about 200 mg of compound per kg of subject's body weight per day, preferably about 0.05 to 100 mg/kg/day, or about 1 to 35 mg/kg/day, in single or divided dosage units (e.g., BID, TID, QID). For a 70-kg human, an illustrative range for a suitable dosage amount is from about 0.05 to about 7 g/day, or about 0.2 to about 2.5 g/day.

Once improvement of the patient's disease, disorder, or condition has occurred, the dose may be adjusted for preventative or maintenance treatment. For example, the dosage or the frequency of administration, or both, may be reduced as a function of the symptoms, to a level at which the desired therapeutic or prophylactic effect is maintained. Of course, if symptoms have been alleviated to an appropriate level, treatment may cease. Patients may, however, require intermittent treatment on a long-term basis upon any recurrence of symptoms.

In addition, the active agents of the invention may be used in combination with additional active ingredients in the treatment of the above conditions. The additional active ingredients may be co-administered separately with an active agent of compounds of Table 1 or included with such an agent in a pharmaceutical composition according to the invention. In an exemplary embodiment, additional active ingredients are those that are known or discovered to be effective in the treatment of conditions, disorders, or diseases mediated by GluN2B activity, such as another GluN2B modulator or a compound active against another target associated with the particular condition, disorder, or disease. The combination may serve to increase efficacy (e.g., by including in the combination a compound potentiating the potency or effectiveness of an active agent according to the invention), decrease one or more side effects, or decrease the required dose of the active agent according to the invention.

The active agents of the invention are used, alone or in combination with one or more additional active ingredients, to formulate pharmaceutical compositions of the invention. A pharmaceutical composition of the invention comprises: (a) an effective amount of at least one active agent in accordance with the invention; and (b) a pharmaceutically acceptable excipient.

A “pharmaceutically acceptable excipient” refers to a substance that is non-toxic, biologically tolerable, and otherwise biologically suitable for administration to a subject, such as an inert substance, added to a pharmacological composition or otherwise used as a vehicle, carrier, or diluent to facilitate administration of an agent and that is compatible therewith. Examples of excipients include calcium carbonate, calcium phosphate, various sugars and types of starch, cellulose derivatives, gelatin, vegetable oils, and polyethylene glycols.

Delivery forms of the pharmaceutical compositions containing one or more dosage units of the active agents may be prepared using suitable pharmaceutical excipients and compounding techniques known or that become available to those skilled in the art. The compositions may be administered in the inventive methods by a suitable route of delivery, e.g., oral, parenteral, rectal, topical, or ocular routes, or by inhalation.

The preparation may be in the form of tablets, capsules, sachets, dragees, powders, granules, lozenges, powders for reconstitution, liquid preparations, or suppositories. Preferably, the compositions are formulated for intravenous infusion, topical administration, or oral administration.

For oral administration, the compounds of the invention can be provided in the form of tablets or capsules, or as a solution, emulsion, or suspension. To prepare the oral compositions, the compounds may be formulated to yield a dosage of, e.g., from about 0.05 to about 100 mg/kg daily, or from about 0.05 to about 35 mg/kg daily, or from about 0.1 to about 10 mg/kg daily. For example, a total daily dosage of about 5 mg to 5 g daily may be accomplished by dosing once, twice, three, or four times per day.

Oral tablets may include a compound according to the invention mixed with pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavoring agents, coloring agents and preservative agents. Suitable inert fillers include sodium and calcium carbonate, sodium and calcium phosphate, lactose, starch, sugar, glucose, methyl cellulose, magnesium stearate, mannitol, sorbitol, and the like. Exemplary liquid oral excipients include ethanol, glycerol, water, and the like. Starch, polyvinyl-pyrrolidone (PVP), sodium starch glycolate, microcrystalline cellulose, and alginic acid are suitable disintegrating agents. Binding agents may include starch and gelatin. The lubricating agent, if present, may be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate to delay absorption in the gastrointestinal tract, or may be coated with an enteric coating.

Capsules for oral administration include hard and soft gelatin capsules. To prepare hard gelatin capsules, compounds of the invention may be mixed with a solid, semi-solid, or liquid diluent. Soft gelatin capsules may be prepared by mixing the compound of the invention with water, an oil such as peanut oil or olive oil, liquid paraffin, a mixture of mono and di-glycerides of short chain fatty acids, polyethylene glycol 400, or propylene glycol.

Liquids for oral administration may be in the form of suspensions, solutions, emulsions or syrups or may be lyophilized or presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid compositions may optionally contain: pharmaceutically-acceptable excipients such as suspending agents (for example, sorbitol, methyl cellulose, sodium alginate, gelatin, hydroxyethylcellulose, carboxymethylcellulose, aluminum stearate gel and the like); non-aqueous vehicles, e.g., oil (for example, almond oil or fractionated coconut oil), propylene glycol, ethyl alcohol, or water; preservatives (for example, methyl or propyl p-hydroxybenzoate or sorbic acid); wetting agents such as lecithin; and, if desired, flavoring or coloring agents.

The active agents of this invention may also be administered by non-oral routes. For example, the compositions may be formulated for rectal administration as a suppository. For parenteral use, including intravenous, intramuscular, intraperitoneal, or subcutaneous routes, the compounds of the invention may be provided in sterile aqueous solutions or suspensions, buffered to an appropriate pH and isotonicity or in parenterally acceptable oil. Suitable aqueous vehicles include Ringer's solution and isotonic sodium chloride. Such forms will be presented in unit-dose form such as ampules or disposable injection devices, in multi-dose forms such as vials from which the appropriate dose may be withdrawn, or in a solid form or pre-concentrate that can be used to prepare an injectable formulation. Illustrative infusion doses may range from about 1 to 1000 μg/kg/minute of compound, admixed with a pharmaceutical carrier over a period ranging from several minutes to several days.

For topical administration, the compounds may be mixed with a pharmaceutical carrier at a concentration of about 0.1% to about 10% of drug to vehicle. Another mode of administering the compounds of the invention may utilize a patch formulation to affect transdermal delivery. Compounds of the invention may alternatively be administered in methods of this invention by inhalation, via the nasal or oral routes, e.g., in a spray formulation also containing a suitable carrier. Exemplary compounds useful in methods of the invention will now be described by reference to the illustrative synthetic schemes for their general preparation below and the specific examples that follow. Artisans will recognize that, to obtain the various compounds herein, starting materials may be suitably selected so that the ultimately desired substituents will be carried through the reaction scheme with or without protection as appropriate to yield the desired product. Alternatively, it may be necessary or desirable to employ, in the place of the ultimately desired substituent, a suitable group that may be carried through the reaction scheme and replaced as appropriate with the desired substituent. Unless otherwise specified, the variables are as defined above in reference to Formula (I). Reactions may be performed between the melting point and the reflux temperature of the solvent, and preferably between 0° C. and the reflux temperature of the solvent. Reactions may be heated employing conventional heating or microwave heating. Reactions may also be conducted in sealed pressure vessels above the normal reflux temperature of the solvent.

Abbreviations and acronyms used herein include the following:

TABLE 2 Term Acronym Aqueous aq Atmosphere atm tert-Butylcarbamoyl Boc Broad br Diatomaceous Earth Celite ® Electrospray ionization ESI Normal-phase silica gel chromatography FCC GluNR2B* GluN_(2B), NMDA- R2B, NR2B, hNR3 Grams g Hours h High-pressure liquid chromatography HPLC Hertz Hz Isopropyl alcohol iPrOH, IPA Liquid chromatography and mass spectrometry LCMS Molar M Mass to charge ratio m/z Milligrams mg Minute min Milliliter mL Microliter μL Millimoles mmol Mass spectrometry MS Normal N Nuclear magnetic resonance NMR Parts per million ppm Precipitate ppt Polytetrafluoroethylene PTFE Retention time R_(t) Room temperature rt Saturated sat Supercritical Fluid Chromatography SFC Temperature T Thin layer chromatography TLC Volume in milliliters of solvent per gram of substrate V, or volumes *(Collingridge, G.L, et al, Neuropharmacology, 2009, 56, 2-5)

PREPARATIVE EXAMPLES

Exemplary compounds useful in methods of the invention will now be described by reference to the illustrative synthetic schemes for their general preparation below and the specific examples to follow.

According to SCHEME 1, commercially available or synthetically accessible 6-bromo-1H-pyrazolo[4,3-b]pyridine is halogenated under conditions known to one skilled in the art, to provide a compound of formula (V), where R^(t) is halo. For example, 6-bromo-1H-pyrazolo[4,3-b]pyridine is fluorinated using an electrophilic fluorine source such as, N-fluorobenzenesulfonimide (NFSI), N-fluoro-o-benzenedisulfonimide (NFOBS), or 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectflor®), preferably Selectflor®; in a suitable solvent such as acetonitrile (ACN), and the like; at temperatures ranging from 0 to 100° C.; to provide a compound of formula (V), where R¹ is F.

According to SCHEME 2, a 2-haloacetyl chloride of formula (VI), where X is Cl or Br, such as 2-chloroacetyl chloride, 2-bromoacetyl chloride, and the like; is reacted with a commercially available or synthetically accessible suitably substituted azetidine of formula (VII), where R^(a) is H, halo, or C₁₋₆alkyl, and n is 1 or 2; or a suitably substituted heterocycloalkylamine of formula (IX), where ring A is as described in Formula (IB); or a suitably substituted amine of formula (XI), where R^(d) is C₃₋₆cycloalkyl or C₃₋₆cycloalkyl substituted with two F members, and R^(e) is H or CH₃; in the presence of a suitable base such as triethylamine (TEA) or sodium bicarbonate; in a solvent such as acetonitrile (ACN) or dichloromethane (DCM); at temperatures ranging from 0° C. to rt; to provide a compound of formula (VIII), formula (X), and formula (XII).

According to SCHEME 3, difluorination of bromoaryl carbaldehyde (II) is achieved employing diethylaminosulfur trifluoride (DAST), and the like; in a suitable solvent such as DCM; to provide bromo (difluoromethyl)aryl (III). Bromo (difluoromethyl)aryl (III), is borylated by methods known to those skilled in the art, for example, bromo (difluoromethyl)aryl (III) may be treated with a transition metal catalyst, 1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (Pd(dppf)Cl₂) for example, in a solvent like dimethylsulfoxide (DMSO) or 1,4-dioxane, and a base like KOAc with bis(pinacolato)diboron to give a compound of formula (IV).

Alternatively, a compound of formula (III), 2-bromo-5-(difluoromethyl)thiophene for example, is borylated via a metal halogen exchange of the bromide with organolithium or magnesium reagents, with or without the presence of lithium chloride at a temperature of about −78° C. in a solvent like ether or tetrahydrofuran (THF) and the like, followed by treatment with 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane to give a compound of formula (IV), 2-(5-(difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane for example.

According to SCHEME 4, a compound of formula (V), where R¹ is H, CH₃, or F, is alkylated with a compound of formula (VIII), (X), or (XII), where X is Cl or Br, employing a base such as Cs₂CO₃, NaH, and the like; in a suitable solvent such as dimethylformamide (DMF), and the like; at temperatures ranging from 0° C. to rt; to afford a compound of formula (XIII), where R² is as defined in claim 1. A compound of formula (XIII) is reacted in a metal mediated cross coupling reaction to provide a compound of Formula (I), where Ar¹ is as defined in claim 1. For example, a compound of formula (XIII), where H, CH₃, or F, is reacted with a suitably substituted aryl or heteroaryl boronic acid, boronate ester, and the like; in the presence of a palladium catalyst such as PdCl₂(dtbpf), Pd(PPh₃)₄, bis(triphenylphosphine)palladium(II)chloride (PdCl₂(PPh₃)₂), bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane, (2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate (RuPhos Pd G3), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (Pd(dppf)Cl₂), and the like; a base such as KF, K₃PO₄, aq. Na₂CO₃, Cs₂CO₃, and the like; in a suitable solvent such as 1,4-dioxane, DMF, acetonitrile (ACN), water, or a mixture thereof; at a temperature ranging from 60 to 120° C.; for a period of about 16 to 48 hours; to provide a compound of Formula (I).

According to SCHEME 5, a compound of formula (V), where R¹ is H, CH₃, or F, is reacted in a metal-mediated cross-coupling reaction with a suitably substituted aryl or heteroaryl boronic acid, boronate ester as previously described, to provide a compound of formula (XIV), where Ar¹ is a group as defined in Formula (I). Subsequent alkylation with a compound of formula (VIII), or formula (X), or formula (XII), employing conditions previously described provides a compound of Formula (I).

According to SCHEME 6, a compound of formula (V) or a compound of formula (XV) where R¹ is H, CH₃, or F and Ar¹ is as described in Formula (I), is alkylated with an electrophile such as ethyl 2-bromoacetate, tert-butyl 2-bromoacetate, and the like; a base such as NaH, Cs₂CO₃, and the like; in a suitable solvent such as DMF, and the like; at temperatures ranging from 0° C. to rt. A compound of formula (XIV) is coupled in a metal-mediated cross coupling reaction as previously described, with a suitably substituted phenyl or thienyl boronic acid or ester, employing conditions previously described, to provide a compound of formula (XVI).

A compound of formula (XVI), where Ar¹ is phenyl substituted with CH₂OH, is fluorinated with a fluorinating agent such as bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor®), in a suitable solvent such as DCM, and the like; at 0° C.; for a period of 1 to 4 hours, provides a compound of formula (XVI), where Ar¹ is phenyl substituted with CH₂F.

Saponification of an ester of formula (XVI) under basic conditions such as NaOH, LiOH, KOH, and the like; in a suitable solvent such as methanol (MeOH), ethanol (EtOH), THF, ACN, H₂O, or a mixture thereof, affords a compound of formula (XVII). Alternatively, acidic hydrolysis of an ester of formula (XVI) is accomplished using an acidic solvent such as 6 N aqueous HCl and the like; at temperatures ranging from room temperature (rt) to 80° C.; to afford a compound of formula (XVII). It will be understood that in certain instances, in situ ester hydrolysis, without the isolation of a discrete ester (XVI) may occur to provide a compound of formula (XVII).

According to SCHEME 7, a compound of Formula (I), where R¹ is H, CH₃, or F, Ar¹ is a suitably substituted phenyl or thienyl, and R² is as defined in claim 1, is prepared by conventional amide bond-forming techniques such as coupling reactions which are well known to those skilled in the art (such as HATU (1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate), BOP (benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate), or conversion of the acid to an acid chloride). For example, reaction of a suitably substituted heterocycloalkyl amine of formula (IX), or a suitably substituted azetidine of formula (XVIII), or an amine of formula (XI) where R^(d) is as defined in claim 1 and R^(e) is H or CH₃, with an acid compound of formula (XVII), where the acid is activated with an appropriate activating reagent, for example a carbodiimide, such as N,N′-dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) optionally in the presence of hydroxybenzotriazole (HOBt) and/or a catalyst such as 4-dimethylaminopyridine (DMAP); a halotrisaminophosphonium salt such as (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), or bromotripyrrolidinophosphonium hexafluorophosphate (PyBroP®); a suitable pyridinium salt such as 2-chloro-1-methyl pyridinium chloride; or another suitable coupling agent such as N,N,N′,N′-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide (T3P®) and the like. Coupling reactions are conducted in a suitable solvent such as DCM, THF, DMF and the like, optionally in the presence of a tertiary amine such as N-methylmorpholine, N-ethyldiisopropylamine (DIEA, DIPEA), or triethylamine (TEA), at a temperature ranging from about 0° C. to rt, to provide compound a of Formula (I).

Compounds of Formula (I) may be converted to their corresponding salts using methods known to one of ordinary skill in the art. For example, an amine of Formula (I) is treated with trifluoroacetic acid, HCl, or citric acid in a solvent such as Et₂O, CH₂Cl₂, THF, MeOH, chloroform, or isopropanol to provide the corresponding salt form. Alternately, trifluoroacetic acid or formic acid salts are obtained as a result of reverse phase HPLC purification conditions. Crystalline forms of pharmaceutically acceptable salts of compounds of Formula (I) may be obtained in crystalline form by recrystallization from polar solvents (including mixtures of polar solvents and aqueous mixtures of polar solvents) or from non-polar solvents (including mixtures of non-polar solvents).

Where the compounds according to this invention have at least one chiral center, they may accordingly exist as enantiomers. Where the compounds possess two or more chiral centers, they may additionally exist as diastereomers. It is to be understood that all such isomers and mixtures thereof are encompassed within the scope of the present invention.

Compounds prepared according to the schemes described above may be obtained as single forms, such as single enantiomers, by form-specific synthesis, or by resolution. Compounds prepared according to the schemes above may alternately be obtained as mixtures of various forms, such as racemic (1:1) or non-racemic (not 1:1) mixtures. Where racemic and non-racemic mixtures of enantiomers are obtained, single enantiomers may be isolated using conventional separation methods known to one of ordinary skill in the art, such as chiral chromatography, recrystallization, diastereomeric salt formation, derivatization into diastereomeric adducts, biotransformation, or enzymatic transformation. Where regioisomeric or diastereomeric mixtures are obtained, as applicable, single isomers may be separated using conventional methods such as chromatography or crystallization.

The following specific examples are provided to further illustrate the invention and various preferred embodiments.

EXAMPLES

In obtaining the compounds described in the examples below and the corresponding analytical data, the following experimental and analytical protocols were followed unless otherwise indicated.

Unless otherwise stated, reaction mixtures were magnetically stirred at room temperature (rt) under a nitrogen atmosphere. Where solutions were “dried,” they were generally dried over a drying agent such as Na₂SO₄ or MgSO₄. Where mixtures, solutions, and extracts were “concentrated”, they were typically concentrated on a rotary evaporator under reduced pressure. Reactions under microwave irradiation conditions were carried out in a Biotage Initiator or CEM (Microwave Reactor) Discover instrument.

For the reactions conducted under continuous flow conditions, “flowed through a LTF-VS mixer” refers to the use of a Chemyx Fusion 100 Touch Syringe Pump that is in line via 1/16″ PTFE tubing to a LTF-VS mixer (Little Things Factory GmbH (http://www.ltf-gmbh.com), unless otherwise indicated.

Normal-phase silica gel chromatography (FCC) was performed on silica gel (SiO₂) using prepacked cartridges.

Preparative reverse-phase high performance liquid chromatography (RP HPLC) was performed on either:

Method A.

An Agilent HPLC with an Xterra Prep RP18 column (5 μM, 30×100 or 50×150 mm) or an XBridge C18 OBD column (5 μM, 30×100 or 50×150 mm), and a mobile phase of 5% ACN in 20 mM NH₄OH was held for 2 min, then a gradient of 5-99% ACN over 15 min, then held at 99% ACN for 5 min, with a flow rate of 40 or 80 mL/min. or METHOD B. A Shimadzu LC-8A Series HPLC with an Inertsil ODS-3 column (3 m, 30×100 mm, T=45° C.), mobile phase of 5% ACN in H₂O (both with 0.05% TFA) was held for 1 min, then a gradient of 5-99% ACN over 6 min, then held at 99% ACN for 3 min, with a flow rate of 80 mL/min. or

Method C.

A Shimadzu LC-8A Series HPLC with an XBridge C18 OBD column (5 m, 50×100 mm), mobile phase of 5% ACN in H₂O (both with 0.05% TFA) was held for 1 min, then a gradient of 5-99% ACN over 14 min, then held at 99% ACN for 10 min, with a flow rate of 80 mL/min.

or

Method D.

A Gilson HPLC with an XBridge C18 column (5 μm, 100×50 mm), mobile phase of 5-99% ACN in 20 mM NH₄OH over 10 min and then hold at 99 ACN for 2 min, at a flow rate of 80 mL/min.

or

Method E.

A Wufeng LC100 equipped with a manual Rheodyne 3725i sampler with a Gemini-NX C18 column (5 μM, 30×100 mm), and a mobile phase of 0-90% ACN:10 mM (NH₄)HCO₃ (9:1) in 10 mM aqueous (NH₄)HCO₃ with 0.1% NH₄OH over 16 min or 18 min, with a flow rate of 30 mL/min.

Method F.

A Gilson HPLC with C18 XBridge column (30×100 mm 5 um), mobile phase: Gradient from 60% 0.1% NH₄CO₃H/NH₄OH pH 9 solution in Water, 40% CH₃CN to 43% 0.1% NH₄CO₃H/NH₄OH pH 9 solution in Water, 57% CH₃CN, at a flow rate of 80 mL/min.

Preparative supercritical fluid high performance liquid chromatography (SFC) was performed either on a Jasco preparative SFC system, an APS 1010 system from Berger instruments, or a SFC-PICLAB-PREP 200 (PIC SOLUTION, Avignon, France). The separations were conducted at 100 to 150 bar with a flow rate ranging from 40 to 60 mL/min. The column was heated to 35 to 40° C.

Mass spectra (MS) were obtained on an Agilent series 1100 MSD using electrospray ionization (ESI) in positive mode unless otherwise indicated. Calculated (calcd.) mass corresponds to the exact mass.

Nuclear magnetic resonance (NMR) spectra were obtained on Bruker model DRX spectrometers. Definitions for multiplicity are as follows: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet, br=broad. It will be understood that for compounds comprising an exchangeable proton, said proton may or may not be visible on an NMR spectrum depending on the choice of solvent used for running the NMR spectrum and the concentration of the compound in the solution.

Chemical names were generated using ChemDraw Ultra 17.1 (CambridgeSoft Corp., Cambridge, Mass.) or OEMetaChem V1.4.0.4 (Open Eye).

Compounds designated as R* or S* are enantiopure compounds where the absolute configuration was not determined.

EXAMPLES Intermediate 1: 2-Chloro-1-(3-fluoroazetidin-1-yl)ethanone

Method A.

To a mixture of chloroacetyl chloride (1.57 mL, 19.7 mmol, 1.42 g/mL) and sodium bicarbonate (NaHCO₃) (4.52 g, 53.8 mmol) in dichloromethane (DCM) (40 mL) was added 3-fluoroazetidine hydrochloride (2.0 g, 17.9 mmol) in portions at 0° C. under argon and the reaction was stirred at 0° C. for 2 h. The reaction mixture was allowed to reach room temperature and stirred for 1 h. The mixture was filtered, and the precipitate was washed with DCM (3×4 mL). The combined filtrates were evaporated to give the title compound (2.70 g, 17.8 mmol, 99%) as a colorless liquid. MS (ESI): mass calcd. for C₅H₇ClFNO, 151.0; m/z found, 152.1 [M+H]⁺.

Method B.

Potassium carbonate (K₂CO₃) (46 g, 330 mmol) and 3-fluoroazetidine (16.7 g, 150 mmol) were stirred in 100 mL distilled water until all solids had dissolved completely. To this solution was added 100 mL DCM, and the biphasic reaction was cooled to 0° C. and stirred vigorously while chloroacetyl chloride (14.3 mL, 180 mmol,) was added dropwise. Upon completion of addition, the reaction mixture was stirred at rt for 2 hours, diluted with water until all solids dissolved. The layers were separated, and the aqueous layer was extracted 4× with DCM. The combined organics were concentrated to afford the title compound as a pale-yellow liquid, which was sufficiently pure for use directly in subsequent steps (15.9 g, 105 mmol, 70%). ¹H NMR (400 MHz, CDCl₃) δ 5.54-5.15 (m, 1H), 4.68-4.50 (m, 1H), 4.48-4.26 (m, 2H), 4.28-4.11 (m, 1H), 3.92 (s, 2H).

Intermediate 2: 2-Chloro-N-(3,3-difluorocyclobutyl)acetamide

The title compound was made in a manner analogous to Method A of Intermediate 1 using 3,3-difluorocyclobutan-1-amine in place of 3-fluoroazetidine. MS (ESI): mass calcd. for C₆H₈ClF₂NO; 183.0 m/z found, 182.1 [M−H]⁻.

Intermediate 3: 2-Chloro-1-(3,3-difluoropyrrolidin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Method A of Intermediate 1 using 3,3-difluoropyrrolidine in place of 3-fluoroazetidine. MS (ESI): mass calcd. for C₆H₈ClF₂NO; 183.0 m/z found, 184.1 [M+H]⁺.

Intermediate 4: (racemic) 2-Chloro-1-(3-hydroxypyrrolidin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Method A of Intermediate 1 using 3-hydroxypyrrolidine in place of 3-fluoroazetidine. MS (ESI): mass calcd. for C₆H₁₀ClNO₂; 163.0 m/z found, 164.1 [M+H]⁺.

Intermediate 5: (racemic) 2-Chloro-1-(3-fluoropyrrolidin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Method A of Intermediate 1 using 3-fluoropyrrolidine in place of 3-fluoroazetidine. MS (ESI): mass calcd. for C₆H₉ClFNO; 165.0 m/z found, 166.1 [M+H]⁺.

Intermediate 6: 2-Chloro-1-(3-methylazetidin-1-yl)ethan-1-one

To a solution of 3-methylazetidine hydrochloride (500 mg, 4.65 mmol) in DCM (7.75 mL) was added K₂CO₃ (1.93 g, 14.0 mmol) at 0° C. and the reaction was stirred for 10 min. To the reaction mixture was added chloroacetyl chloride (407 μL, 5.11 mmol, 1.42 g/mL) dropwise at 0° C. The reaction mixture was allowed to reach room temperature and stirred for 17 h. The suspension was filtered, and the precipitate was washed with DCM (2×10 mL). The combined filtrates were concentrated under reduced pressure. Purification (FCC, SiO₂, 0 to 100% DCM/MeOH) afforded the title compound (580 mg, 3.93 mmol, 85%) as a yellow oil. MS (ESI): mass calcd. for C₆H₁₀ClNO; 147.1 m/z found, 148.1 [M+H]⁺.

Intermediate 7: 2-Chloro-N-cyclobutylacetamide

To a solution of cyclobutylamine (1.0 g, 14.1 mmol) in freshly distilled tetrahydrofuran (THF) (60 mL) was added triethylamine (Et₃N) (2.16 mL, 15.5 mmol, 0.726 g/mL) dropwise at room temperature. The mixture was cooled to 0° C. Chloroacetyl chloride (1.23 mL, 15.5 mmol, 1.42 g/mL) at 0° C. was then added and the reaction stirred for 1 h. The reaction mixture was allowed to reach room temperature and stirred for 17 h. The reaction mixture was concentrated, and the residue was taken up in water (70 mL) and extracted with ethyl acetate (EtOAc) (1×70 mL). The organic layer was washed with 1 M hydrochloric acid (HCl) (1×35 mL), saturated NaHCO₃(1×35 mL), and saturated ammonium chloride (NH₄Cl) (1×35 mL), dried over sodium sulfate (Na₂SO₄), filtered and concentrated. Purification (FCC, SiO₂, 10 to 100% n-heptane/EtOAc) afforded a residue that was triturated with n-heptane (10 mL) to give the title compound (1.37 g, 9.28 mmol, 66%) as a white crystalline solid. MS (ESI): mass calcd. for C₆H₁₀ClNO; 147.1 m/z found, 148.1 [M+H]⁺.

Intermediate 8: 2-(5-(Difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Step A. 2-Bromo-5-(difluoromethyl)thiophene

To dimethylaminosulfur trifluoride (5.6 mL, 42.4 mmol, 1.22 g/mL) was added 5-bromothiophene-2-carbaldehyde (2.00 g, 10.5 mmol) dropwise at 0° C. under argon. The reaction mixture was then stirred at room temperature for 2 h. The reaction was quenched by dropwise addition of 2 M sodium hydroxide (NaOH) (10 mL) at 0° C. The layers were separated, and the aqueous layer was extracted with EtOAc (2×20 mL). The combined organics were dried over Na₂SO₄, filtered and concentrated under reduced pressure. Purification (FCC, SiO₂, n-heptane) afforded title compound (1.07 g, 5.03 mmol, 48%) as a colorless liquid. No mass ion found in MS.

Step B. 2-(5-(Difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

To a solution of 2-bromo-5-(difluoromethyl)thiophene (930 mg, 4.37 mmol) in THE (17 mL) was added n-butyllithium (n-BuLi)(1.6 M in hexanes, 3 mL, 4.8 mmol) dropwise at −78° C. under argon and the reaction mixture was stirred at −78° C. for 1 h. To the reaction mixture was added a solution of 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (980 μL, 4.8 mmol, 0.912 g/mL) in THE (2 mL) and the reaction was stirred at −78° C. for 1 h. The reaction mixture was allowed to reach room temperature and then stirred for 16 h. The reaction was diluted with saturated NH₄Cl (30 mL) and EtOAc (40 mL). The layers were separated, and the aqueous layer was extracted with EtOAc (1×50 mL). The combined organics were dried over Na₂SO₄, filtered and concentrated to give the title compound (1.00 g) as a brown oil that was used without further purification. The corresponding boronic acid MS (ESI): mass calcd. for C₅H₅BF₂O₂S; 178.0 m/z found, 177.1 [M−H]⁻.

Intermediate 9: 6-Bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine

To a solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (2.5 g, 12.6 mmol) in acetonitrile (62.5 mL) was added N-fluoro-N′-(chloromethyl)triethylenediamine bis(tetrafluoroborate) (6.7 g, 18.9 mmol). The reaction mixture was stirred at 90° C. for 22 h. The reaction mixture was poured into water (120 mL) and was diluted with EtOAc (80 mL). The layers were separated, and the aqueous layer was extracted with EtOAc (2×60 mL). The combined organic layers were dried over MgSO₄, filtered and concentrated under reduced pressure. The residue was purified by basic reverse phase preparative HPLC (Method E) to afford the title compound (641 mg, 2.97 mmol, 23%) as a brown powder. MS (ESI): mass calcd. for C₆H₃BrFN₃; 214.9 m/z found, 216.0 [M+H]⁺.

Intermediate 10: 2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide

Method A.

To a solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (2.00 g, 10.1 mmol) in dry DMF (40 mL) was added NaH (60% in mineral oil, 444 mg, 11.1 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 0.5 h. To the reaction mixture was added 2-chloro-N,N-dimethylacetamide (1.14 mL, 11.1 mmol, 1.18 g/mL) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 18 h. The reaction mixture was poured into water (50 mL) and the mixture was extracted with ethyl acetate (EA, EtOAc) (3×40 mL). The combined organic layers were evaporated. Purification (FCC, SiO₂, 25 to 100% hexanes/EtOAc) afforded a solid that was triturated with Et₂O (4 mL) to afford the title compound (1.83 g, 6.47 mmol, 64%) as an off-white powder. MS (ESI): mass calcd for C₁₀H₁₁BrN₄O, 282.0; m/z found, 283.0 [M+H]⁺

Method B.

A solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (15.0 g, 75.7 mmol) in DMF (250 mL) was treated with 2-chloro-N,N-dimethylacetamide (8.6 mL, 83 mmol) and K₂CO₃ (12.6 g, 90.9 mmol) and the reaction mixture was stirred at r.t. overnight. DMF was removed under reduced pressure until approximately 50 mL total volume, then diluted with water (300 mL) and let stand overnight. The resulting precipitate was collected by filtration to afford the title compound (14.0 g, 49.5 mmol, 65%). MS (ESI): mass calcd for C₁₀H₁₁BrN₄O, 282.0; m/z found, 283.0 [M+H]⁺. ¹H NMR (400 MHz, CHCl3-d) δ 8.60 (d, J=1.9 Hz, 1H), 8.22 (d, J=1.0 Hz, 1H), 8.00 (dd, J=1.9, 1.0 Hz, 1H), 5.20 (s, 2H), 3.15 (s, 3H), 2.99 (s, 3H).

Intermediate 11: 2-(6-Bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide

The title compound was made in a manner analogous to Method A of Intermediate 10 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9). MS (ESI): mass calcd for C₁₀H₁₀BrFN₄O, 300.0; m/z found, 301.0 [M+H]⁺.

Intermediate 12: 2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one

A solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (10.0 g, 50.5 mmol) in DMF (100 mL) was treated with 2-chloro-1-(3-fluoroazetidin-1-yl)ethan-1-one (8.42 g, 55.5 mmol) and K₂CO₃ (8.4 g, 61 mmol). The reaction mixture was stirred at r.t. for 48 hours. The reaction mixture was partitioned between DCM and water, the aqueous layer was extracted DCM (2×). The combined organics were concentrated. The residual DMF was removed under azeotropic conditions with heptanes. Purification (FCC, SiO₂, 0 to 10% DCM/MeOH) afforded a solid that was then recrystallized from EtOAc. Isolated 8.33 g (26.6 mmol, 53%) of the title compound. MS (ESI): mass calcd for C₁₁H₁₀BrFN₄O, 312.0; m/z found, 313.0 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.61 (d, J=2.0 Hz, 1H), 8.51 (dd, J=2.0, 1.0 Hz, 1H), 8.36 (d, J=1.0 Hz, 1H), 5.57-5.37 (m, 1H), 5.28 (d, J=4.1 Hz, 2H), 4.65-4.45 (m, 1H), 4.42-4.16 (m, 2H), 4.06-3.92 (m, 1H).

Intermediate 13: 1-(Azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Method A of Intermediate 10 using 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd for C₁₁H₁₁BrN₄O, 294.0; m/z found, 295.0 [M+H]⁺.

Intermediate 14: 1-(Azetidin-1-yl)-2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Method A of Intermediate 10 using 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide and 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd for C₁₁H₁₀BrFN₄O, 312.0; m/z found, 313.0 [M+H]⁺.

Intermediate 15: 2-(6-Bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one

The title compound was made in a manner analogous to Intermediate 12 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd for C₁₁H₉BrF₂N₄O, 329.9; m/z found, 331.0 [M+H]⁺.

Intermediate 16: 6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine

A mixture of 6-bromo-1H-pyrazolo[4,3-b]pyridine (1.40 g, 7.07 mmol), 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2.31 g, 8.49 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.673 g, 0.92 mmol) and Na₂CO₃ (2.25 g, 21.2 mmol) in degassed acetonitrile (24.4 mL) and water (3.76 mL) was stirred at 120° C. for 4 h under microwave irradiation. The reaction mixture was poured into water (30 mL) and the mixture was extracted with EtOAc (3×30 mL). The combined organic layers were dried over Na₂SO₄, filtered and concentrated under reduced pressure. Purification (FCC, SiO₂, 10 to 50% n-heptane/EtOAc) afforded a solid that was triturated with Et₂O (4 mL) to afford the title compound (1.41 g, 5.36 mmol, 76%) as an off-white powder. MS (ESI): mass calcd for C₁₃H₈F₃N₃, 263.1; m/z found, 264.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 13.48 (br s, 1H), 8.84 (d, J=2.0 Hz, 1H), 8.41-8.30 (m, 1H), 8.30-8.20 (m, 1H), 8.13-7.99 (m, 2H), 7.60-7.49 (m, 1H), 7.27 (t, J=54.1 Hz, 1H).

Intermediate 17: 6-(3-(Difluoromethoxy)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 2-(3-(difluoromethoxy)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₃H₈F₃N₃O, 279.0; m/z found, 280.2 [M+H]⁺.

Intermediate 18: 6-(4-Chloro-3-(difluoromethoxy)phenyl)-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 2-(3-(difluoromethoxy)-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₃H₈ClF₂N₃O, 295.0; m/z found, 296.0 [M+H]⁺.

Intermediate 19: 6-(3-(1,1-Difluoroethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 2-(3-(1,1-difluoroethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₄H₁₀F₃N₃, 277.1; m/z found, 278.1 [M+H]⁺.

Intermediate 20: 6-(3-(1,1-Difluoroethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 2-(3-(1,1-difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₄H₁₁F₂N₃, 259.1; m/z found, 260.1 [M+H]⁺.

Intermediate 21: 6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd for C₁₃H₇F₄N₃, 281.1; m/z found, 282.1 [M+H]⁺.

Intermediate 22: 6-(4-Chloro-3-(difluoromethoxy)phenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine and 2-(3-(difluoromethoxy)-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₃H₇ClF₃N₃O, 313.0; m/z found, 314.1 [M+H]⁺.

Intermediate 23: 6-(3-(Difluoromethoxy)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine and using 2-(3-(difluoromethoxy)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₃H₇F₄N₃O, 297.1; m/z found, 298.0 [M+H]⁺.

Intermediate 24: 6-(3-(1,1-Difluoroethyl)phenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 9) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine and using 2-(3-(1,1-difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₄H₁₀F₃N₃, 277.1; m/z found, 278.1 [M+H]⁺.

Intermediate 25: 6-(4-Fluoro-3-methylphenyl)-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16 using 2-(4-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2-[3-(difluoromethyl)-4-fluoro-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd for C₁₃H₁₀FN₃, 227.1; m/z found, 228.1 [M+H]⁺.

Intermediate 26: 6-(3-(Difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine

The title compound was made in a manner analogous to Intermediate 16, using 6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridine in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd. for C₁₄H₁₀F₃N₃, 277.1; m/z found, 278.1 [M+H]⁺.

Intermediate 27: 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

Step A. Ethyl 2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetate. To a solution of 6-[3-(difluoromethyl)-4-fluoro-phenyl]-1H-pyrazolo[4,3-b]pyridine (Intermediate 16, 2.00 g, 7.6 mmol) in DMF (30 mL) was added Cs₂CO₃ (2.72 g, 8.35 mmol) at 0° C. The reaction was stirred at 0° C. for 30 min. To the reaction mixture was added ethyl chloroacetate (895 μL, 8.36 mmol, 1.14 g/mL) at 0° C. The reaction mixture was allowed to warm to room temperature and stirred for 1 h. The reaction mixture was poured into water (50 mL) and the mixture was extracted with EtOAc (3×75 mL). The organic layers were combined and concentrated under reduced pressure. Purification (FCC, SiO₂, 0 to 75% n-heptane/EtOAc) afforded the title compound (1.60 g, 4.58 mmol, 60%) as a white powder. MS (ESI): mass calcd for C₁₇H₁₄F₃N₃₀₂, 349.1; m/z found, 350.1 [M+H]⁺.

Step B. 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetic acid

To a solution of ethyl 2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetate (1.60 g, 4.58 mmol) in 1,4-dioxane (14 mL) and water (9 mL) was added lithium hydroxide monohydrate (385 mg, 9.17 mmol) and the mixture was stirred at room temperature for 1 h, concentrated to ˜9 mL and diluted with water (75 mL). The mixture was acidified to pH 4 with 1 M HCl. The precipitate was collected and washed with water (2×10 mL) and Et₂O (3×10 mL) to afford the title compound (1.74 g, 5.416 mmol, 118%) as a white powder that was used without further purification. MS (ESI): mass calcd for C₁₅H₁₀F₃N₃O₂, 321.1; m/z found, 322.1 [M+H]⁺.

Intermediate 28: 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was made in a manner analogous to Intermediate 27, using 6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 21) in place of 6-[3-(difluoromethyl)-4-fluorophenyl]-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd for C₁₅H₉F₄N₃O₂, 339.1; m/z found, 340.1 [M+H]⁺.

Intermediate 29: 2-(6-(3-(Difluoromethoxy)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was made in a manner analogous to Intermediate 27, using 6-(3-(difluoromethoxy)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 17) in place of 6-[3-(difluoromethyl)-4-fluorophenyl]-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd for C₁₅H₁₀F₃N₃O₃, 337.1; m/z found, 338.1 [M+H]⁺.

Intermediate 30: 6-(4-Fluorophenyl)-1H-pyrazolo[4,3-b]pyridine

6-Bromo-1H-pyrazolo[4,3-b]pyridine (845 mg, 4.27 mmol), 4-fluorophenylboronic acid (896 mg, 6.40 mmol) and sodium carbonate (1.36 g, 12.8 mmol) were taken up in dioxane (15 mL) and water (5 mL). A stream of nitrogen gas was bubbled through the reaction mixture for 10 minutes, then tetrakis(triphenylphosphine)palladium (247 mg, 0.21 mmol) was added, and the reaction mixture was stirred at 90° C. for 24 hours. The reaction mixture was cooled to room temperature, diluted with water and DCM, and the aqueous layer was extracted using DCM (2×). The combined organic layers were dried (MgSO₄), concentrated, and adsorbed onto silica gel. Purification (FCC, SiO₂, 0-100% hexanes/EtOAc then 3-8% MeOH/DCM) afforded the title compound (530 mg, 58%). MS (ESI): mass calcd. for C₁₂H₈FN₃, 213.1; m/z found, 214.1 [M+H]⁺.

Intermediate 31: 2-(6-(4-Fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

Step A. Ethyl 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

6-(4-Fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 30, 470 mg, 2.20 mmol) was taken up in DMF (7 mL) and heated to 50° C. To this solution was added sodium hydride (60% dispersion in mineral oil, 106 mg, 2.65 mmol) and the reaction mixture was stirred for 15 minutes at 50° C. The mixture was allowed to cool to room temperature and ethyl bromoacetate (515 mg, 3.09 mmol) was added. The reaction mixture was stirred at room temperature for 3 hours, poured onto ice, and extracted EtOAc (2×). The combined organic layers were dried (MgSO₄) and concentrated. Purification (FCC, SiO₂, 0 to 100% hexanes/EtOAc) afforded 422 mg (1.41 mmol, 64%). MS (ESI): mass calcd. for C₁₆H₁₄FN₃O₂, 299.1; m/z found, 300.1 [M+H]⁺.

Step B. 2-(6-(4-Fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid Ethyl 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (400 mg, 1.34 mmol) and sodium hydroxide (80 mg, 2.01 mmol) were dissolved in a 1:1 mixture of water and acetonitrile (10 mL). The reaction was stirred overnight at 50° C. The pH of the mixture was adjusted to pH 1 with aqueous HCl and then extracted with DCM (4×). The combined organic layers were dried (MgSO₄) and concentrated to afford the title compound (400 mg, 1.475 mmol, 110%). The title compound was carried on crude the next steps. MS (ESI): mass calcd. for C₁₄H₁₀FN₃O₂, 271.1; m/z found, 272.1 [M+H]⁺.

Intermediate 32: 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

Step A. Ethyl 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

To a stirred solution of 6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridine (Intermediate 26, 300 mg, 1.08 mmol) in DMF (6 mL) was added Cs₂CO₃ (1.06 g, 3.25 mmol), followed by ethyl bromoacetate (240 mg, 1.41 mmol). The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with water and Et₂O, and the aqueous layer was extracted with Et₂O (2×). The combined organics were washed with water, brine, dried (MgSO₄) and concentrated. Purification (FCC, SiO₂, 0 to 100% hexanes/EtOAc) afforded the title compound (313 mg, 0.861 mmol, 80%). MS (ESI): mass calcd. for C₁₈H₁₆F₃N₃O₂, 363.1; m/z found, 364.1 [M+H]⁺.

Step B. 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

To a solution of ethyl 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (313 mg, 0.861 mmol) in THE (15 mL) was added 4 N aqueous lithium hydroxide (5 mL). The biphasic mixture was stirred vigorously overnight. The reaction mixture was partitioned between water and Et₂O and the layers separated. The organic layer was extracted with water (2×). The combined aqueous layers were acidified to pH 1 with 1N HCl. The resulting precipitate was collected by filtration, washed with water and dried to afford the title compound (293 mg, 100%) as a white solid. The compound was sufficiently pure to be carried on to subsequent steps without further purification. MS (ESI): mass calcd. for C₁₆H₁₂F₃N₃O₂, 335.1; m/z found, 336.1 [M+H]⁺.

Intermediate 33: 3-Ethynylazetidine.HCl salt

Step A. tert-Butyl 3-ethynylazetidine-1-carboxylate

tert-Butyl 3-formylazetidine-1-carboxylate (500 mg, 2.70 mmol), dimethyl (1-diazo-2-oxopropyl)phosphonate (10% wt., 9.2 mL, 4.05 mmol), and potassium carbonate (1120 mg, 8.10 mmol) were taken up in methanol (10 mL). The reaction mixture was stirred at room temperature for 3 hours, concentrated, diluted with diethyl ether and water. The organic layer was separated and was washed with water followed by sat. aqueous sodium carbonate, dried (MgSO₄), and concentrated. Purification (FCC, SiO₂, 0-25% ethyl acetate/hexanes gradient) afforded the title compound (356 mg, 1.96 mmol, 73%). ¹H NMR (400 MHz, CDCl₃) δ 4.14 (t, J=8.5 Hz, 2H), 3.94 (dd, J=8.2, 6.3 Hz, 2H), 3.36-3.25 (m, 1H), 2.28 (d, J=2.4 Hz, 1H), 1.44 (s, 9H).

Step B. 3-Ethynylazetidine.HCl salt

tert-Butyl 3-ethynylazetidine-1-carboxylate (50 mg, 0.28 mmol) was dissolved in 4 N HCl in dioxane (1 mL) and the reaction mixture was stirred for 2 hours at room temperature. The mixture was concentrated, and the hydrochloride salt of the title compound was used directly in the next step without further purification.

Intermediate 34: (Z)-3-(Prop-1-en-1-yl)azetidine.HCl salt

Step A. tert-Butyl (Z)-3-(prop-1-en-1-yl)azetidine-1-carboxylate

Ethyl(triphenyl)phosphonium bromide (1.21 g, 3.24 mmol) was suspended in dry THE (15 mL). The suspension was cooled to 0° C. n-BuLi (2.5M in hexanes, 1.3 mL, 3.24 mmol) was added dropwise to the reaction mixture with stirring, and the reaction mixture was stirred for 1 hour at 0° C. tert-Butyl 3-formylazetidine-1-carboxylate (500 mg, 2.70 mmol) was added slowly to the reaction mixture at 0° C. and the reaction mixture was allowed to warm to rt and stirred overnight. The reaction mixture was concentrated, partitioned between DCM and water, the aqueous layer was extracted using DCM (2×), and the combined organics were concentrated. The crude material was purified on silica gel (FCC, SiO₂, 0-50% ethyl acetate/hexanes gradient) to afford the title compound as a 7:1 mixture of Z/E isomers (318 mg, 1.61 mmol, 60%). ¹H NMR (400 MHz, CDCl₃) δ 5.69-5.56 (m, 1H), 5.56-5.45 (m, 1H), 4.12 (t, J=8.4 Hz, 2H), 3.67 (dd, J=8.4, 6.0 Hz, 2H), 3.50-3.47 (m, 1H), 1.58 (dd, J=6.8, 1.6 Hz, 3H), 1.44 (d, J=1.5 Hz, 9H).

Step B. (Z)-3-(Prop-1-en-1-yl)azetidine.HCl salt

tert-Butyl (Z)-3-(prop-1-en-1-yl)azetidine-1-carboxylate (50 mg, 0.28 mmol) was dissolved in 4 N HCl in dioxane (1 mL) and the reaction mixture was stirred for 2 hours at room temperature. The mixture was concentrated, and the hydrochloride salt of the title compound was used directly in the next step.

Intermediate 35: 3-(2,2-Difluorovinyl)azetidine.HCl salt

Step A. tert-Butyl 3-(2,2-difluorovinyl)azetidine-1-carboxylate

tert-Butyl 3-formylazetidine-1-carboxylate (1000 mg, 5.40 mmol) and triphenylphosphine (2.8 g, 10.8 mmol) were taken up in dry DMF (10 mL) and heated to 100° C. with stirring. Sodium chlorodifluoroacetate (1.7 g, 10.8 mmol) was added portion-wise over 30 minutes, and the reaction mixture was stirred at 100° C. for another 15 minutes after complete addition. The reaction mixture was cooled to room temperature, concentrated under reduced pressure to remove DMF, diluted with DCM, and shaken briefly with 30% aqueous H₂O₂. The resulting bi-phasic mixture was diluted further with DCM and water. The aqueous layer was extracted using DCM (2×) and the combined organics were concentrated. Purification (FCC, SiO₂, 0-50% ethyl acetate/hexanes gradient) afforded the title compound (786 mg, 3.58 mmol, 66%). ¹H NMR (400 MHz, CDCl₃) δ 4.51-4.37 (m, 1H), 4.14 (t, J=8.4 Hz, 2H), 3.70 (dd, J=8.6, 6.0 Hz, 2H), 3.39-3.27 (m, 1H), 1.44 (d, J=0.7 Hz, 9H).

Step B. 3-(2,2-Difluorovinyl)azetidine.HCl salt

tert-Butyl 3-(2,2-difluorovinyl)azetidine-1-carboxylate (75 mg, 0.34 mmol) was dissolved in 4 N HCl in dioxane (1 mL) and the reaction mixture was stirred for 2 hours at room temperature. The mixture was concentrated, and the hydrochloride salt of the title compound was used directly in the next step.

Intermediate 36: (Z)-3-(2-fluorovinyl)azetidine.HCl salt

Step A. tert-Butyl (Z)-3-(2-fluorovinyl)azetidine-1-carboxylate

tert-Butyl 3-(2,2-difluorovinyl)azetidine-1-carboxylate (500 mg, 2.28 mmol), bis(neopentyl glycolato)diboron (1.6 g, 6.8 mmol), and water (120 μL, 6.8 mmol) were dissolved in dimethylacetamide (10 mL) and the solution was degassed by sparging with N₂. Copper thiophene-2-carboxylate (43 mg, 0.23 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos®) (135 mg, 0.23 mmol), and lithium tert-butoxide (565 mg, 6.8 mmol) were added (a strong exotherm occurred upon addition of base). The reaction mixture was stirred overnight at 40° C., then partitioned between water and a mixture of 3:1 ethyl acetate/hexanes. The organic layer was extracted using water (2×). The organic layer was concentrated. Purification (FCC, SiO₂, 0-50% ethyl acetate/hexanes gradient) afforded the title compound (319 mg, 1.59 mmol, 70%) contaminated with approximately 20 mol % starting material and 7 mol % of the E isomer. The title compound was carried as is to the next step. ¹H NMR (400 MHz, CDCl₃) δ 6.66-6.30 (m, 1H), 5.17-4.86 (m, 1H), 4.19-4.12 (m, 2H), 3.74-3.67 (m, 2H), 3.66-3.53 (m, 1H), 1.44 (s, 9H).

Step B. (Z)-3-(2-fluorovinyl)azetidine.HCl salt

tert-Butyl (Z)-3-(2-fluorovinyl)azetidine-1-carboxylate (319 mg, 1.59 mmol) was dissolved in 4 N HCl in dioxane (5 mL) and the reaction mixture was stirred for 2 hours at room temperature. The mixture was concentrated, and the hydrochloride salt of the title compound was used directly without further purification.

Intermediate 37: 6-(5-Chloro-2-thienyl)-1H-pyrazolo[4,3-b]pyridine

To a solution of 6-bromo-1H-pyrazolo[4,3-b]pyridine (500 mg, 2.52 mmol) in degassed 1,4-dioxane (39.4 mL) and water (9.55 mL) was added 5-chlorothiophene-2-boronic acid (431 mg, 2.654 mmol), potassium fluoride (440 mg, 7.57 mmol) and tetrakis(triphenylphosphine)palladium(0) (205 mg, 0.177 mmol). The reaction mixture was stirred at 80° C. for 1 h under argon. Additional 5-chlorothiophene-2-boronic acid (123 mg, 0.757 mmol) and tetrakis(triphenylphosphine)palladium(0) (87 mg, 0.075 mmol) was introduced and the reaction mixture was stirred at 80° C. for 2 h under argon. The reaction mixture was diluted with water (40 mL) and DCM (30 mL). The layers were separated, and the aqueous layer was extracted with DCM (3×40 mL). The combined organics were dried (Na₂SO₄), filtered and concentrated under reduced pressure. Purification (FCC, SiO₂, 25 to 100% n-heptane/EtOAc) afforded the title compound (419 mg, 1.78 mmol, 70%) as a yellow powder after triturating with diethyl ether (7 mL). MS (ESI): mass calcd. for C₁₀H₆ClN₃S, 235.0; m/z found, 236.0 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 13.42 (s, 1H), 8.82 (d, J=2.0 Hz, 1H), 8.35-8.29 (m, 1H), 8.17-8.09 (m, 1H), 7.64 (d, J=4.0 Hz, 1H), 7.25 (d, J=4.0 Hz, 1H).

Intermediate 38: 6-(3-(Trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine

A suspension of 6-bromo-1H-pyrazolo[4,3-b]pyridine (5.0 g, 25.3 mmol), 3-(trifluoromethyl)phenylboronic acid (5.8 g, 30.3 mmol) and palladium-tetrakis(triphenylphosphine) (1.5 g, 1.3 mmol) in aqueous sodium carbonate (2M, 32.5 mL, 64.9 mmol) and 1,4-dioxane (96.9 mL) was stirred at 120° C. under a nitrogen atmosphere. After 48 hours, EtOAc was added and the mixture was washed with H₂O (2×). The organic layer was dried (Na₂SO₄) and concentrated in vacuo. The residue was purified (FCC, SiO₂, 0-50% EtOAc in heptane) to afford a yellowish solid. The solid was triturated using Et₂O and collected by filtration to afford the title compound (2.1 g, 8.0 mmol, 31.6%). MS (ESI): mass calcd. for C₁₃H₈F₃N₃, 263.1; m/z found, 264.1 [M+H]⁺.

Intermediate 39: 2-(6-(3-(Trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

Sodium hydride (60% dispersion in mineral oil, 387.5 mg, 9.7 mmol) was added to a stirred solution of 6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 38, 850 mg, 3.2 mmol) in DMF (20 mL) at 0° C. The reaction mixture was stirred at 0° C. for 10 minutes. Then, ethyl bromoacetate (0.54 mL, 4.8 mmol) was added and the reaction mixture was allowed to warm to room temperature. After 16 hours, aqueous potassium hydroxide (1M, 16.1 mL, 16.1 mmol) was added to the reaction mixture and stirred for 1 hour. The reaction mixture was concentrated in vacuo and the residue was dissolved in water and washed with EtOAc. The aqueous layer was separated and acidified using 1M HCl. The solid was filtered and washed with water, dried and triturated from Et₂O to afford the title product (630 mg, 2.0 mmol, 60.7%). MS (ESI): mass calcd. for C₁₅H₁₀F₃N₃O₂, 321.1; m/z found, 322.2 [M+H]⁺.

Intermediate 40: Ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

6-Bromo-1H-pyrazolo[4,3-b]pyridine (639.5 mg, 3.2 mmol) was added to a suspension of NaH (60% dispersion in mineral oil, 180.8 mg, 4.5 mmol) in DMF (33.7 mL) at room temperature under a nitrogen atmosphere. After 10 minutes, ethyl bromoacetate (0.5 mL, 4.5 mmol) was added to the reaction mixture. After 16 hours, water (80 mL) was added and precipitation slowly occurred. The solids were collected by filtration and were purified (FCC, SiO₂, 0-90% EtOAc in hexanes) to afford the title compound (917 mg, 3.2 mmol, 100%). MS (ESI): mass calcd. for C₁₀H₁₀BrN₃O₂, 283.0; m/z found, 284.0 [M+H]⁺.

Intermediate 41: 2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

Lithium hydroxide (4M in water, 1.9 mL, 7.6 mmol) was added to a mixture of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 40, 1.54 g, 5.4 mmol) in THE (65.9 mL) at room temperature. After 16 hours, complete conversion was observed, and the precipitates were collected by filtration, rinsed with THE and dried under vacuum to afford the title compound (1.16 g, 4.5 mmol, 83.6%). MS (ESI): mass calcd. for C₈HBrN₃O₂, 255.0; m/z found, 256.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.50 (d, J=2.0 Hz, 1H), 8.26-8.24 (m, 1H), 8.17-8.15 (m, 1H), 4.66 (s, 2H).

Intermediate 42: 2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3,3-difluoroazetidin-1-yl)ethan-1-one

A mixture of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 41, 300 mg, 1.2 mmol), 3,3-difluoroazetidine hydrochloride (182 mg, 1.4 mmol), T3P® (50% solution in DMF, 2.1 mL, 3.5 mmol) and DIPEA (0.4 mL, 2.5 mmol) in DCM (11.7 mL) was stirred at room temperature. After 16 hours, complete conversion was observed and water (20 mL) was added. The mixture was extracted with EtOAc (3×35 mL). The combined organics were dried (MgSO₄), filtered and concentrated under vacuum to afford the title compound (287 mg, 0.9 mmol, 74.0%). MS (ESI): mass calcd. for C₁₁H₉BrF₂N₄O, 330.0; m/z found, 331.0 [M+H]⁺.

Intermediate 43: 2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one

The title compound was prepared in a manner analogous to Intermediate 42, using pyrrolidine in place of 3,3-difluoroazetidine hydrochloride. MS (ESI): mass calcd. for C₁₂H₁₃BrN₄O, 308.0; m/z found, 309.0 [M+H]⁺.

Intermediate 44: (S)-2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoropyrrolidin-1-yl)ethan-1-one

The title compound was prepared in a manner analogous to Intermediate 42, using (S)-3-fluoropyrrolidine hydrochloride in place of 3,3-difluoroazetidine hydrochloride. MS (ESI): mass calcd. for C₁₂H₁₂BrFN₄O, 326.0; m/z found, 327.0 [M+H]⁺.

Intermediate 45: (R)-2-(6-Bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoropyrrolidin-1-yl)ethan-1-one

The title compound was prepared in a manner analogous to Intermediate 42, using (R)-3-fluoropyrrolidine hydrochloride in place of 3,3-difluoroazetidine hydrochloride. MS (ESI): mass calcd. for C₁₂H₁₂BrFN₄O, 326.0; m/z found, 327.0 [M+H]⁺.

Intermediate 46: Ethyl 2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

The title compound was prepared in a manner analogous to Intermediate 40, using 6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridine in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd. for C₁₁H₁₂BrN₃O₂, 297.0; m/z found, 298.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.57 (d, J=1.9 Hz, 1H), 8.53 (d, J=1.9 Hz, 1H), 5.33 (s, 2H), 4.14 (q, J=7.1 Hz, 2H), 2.52 (s, 3H), 1.20 (t, J=7.1 Hz, 3H).

Intermediate 47: 2-(6-Bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was prepared in a manner analogous to Intermediate 41, using ethyl 2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 46) in place of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate. MS (ESI): mass calcd. for C₉H₈BrN₃O₂, 269.0; m/z found, 270.0 [M+H]⁺.

Intermediate 48: 1-(Azetidin-1-yl)-2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one

The title compound was prepared in a manner analogous to Intermediate 13 using 2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 47) in place of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid. MS (ESI): mass calcd. for C₁₂H₁₃BrN₄O, 308.0; m/z found, 309.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.54-8.53 (m, 1H), 8.42-8.41 (m, 1H), 5.09 (s, 2H), 4.19 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.8 Hz, 2H), 2.50 (s, 3H), 2.30-2.22 (m, 2H).

Intermediate 49: 3-Methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine

A mixture of 6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridine (200 mg, 0.9 mmol), (3-(trifluoromethyl)phenyl)boronic acid (358 mg, 1.9 mmol), cesium carbonate (614.6 mg, 1.9 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (48.3 mg, 0.07 mmol) in 1,4-dioxane (8.7 mL) and distilled water (1.9 mL) was heated to 90° C. After 16 hours, the reaction mixture was concentrated under vacuum. Purification (FCC, SiO₂, 0-90% EtOAc in hexanes) afforded the title compound (229 mg, 0.8 mmol, 87.6%). MS (ESI): mass calcd. for C₁₄H₁₀F₃N₃, 277.1; m/z found, 278.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 13.06 (s, 1H), 8.83 (d, J=2.0 Hz, 1H), 8.23 (d, J=2.0 Hz, 1H), 8.15-8.10 (m, 2H), 7.84-7.74 (m, 2H), 2.57 (s, 3H).

Intermediate 50: Ethyl 2-(3-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

The title compound was prepared in a manner analogous to Intermediate 40, using 3-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 49) in place of 6-bromo-1H-pyrazolo[4,3-b]pyridine. MS (ESI): mass calcd. for C₁₈H₁₆F₃N₃O₂, 363.1; m/z found, 364.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.85 (d, J=2.1 Hz, 1H), 8.35 (d, J=2.1 Hz, 1H), 8.16-8.10 (m, 2H), 7.83-7.73 (m, 2H), 5.48 (s, 2H), 4.21 (q, J=7.1 Hz, 2H), 2.66 (s, 3H), 1.24 (t, J=7.1 Hz, 3H).

Intermediate 51: 2-(3-Methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was prepared in a manner analogous to Intermediate 41, using ethyl 2-(3-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 50) in place of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate. MS (ESI): mass calcd. for C₁₆H₁₂F₃N₃O₂, 335.1; m/z found, 336.1 [M+H]⁺.

Intermediate 52: 2-(6-(4-Fluoro-3-methylphenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

A mixture of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 41, 90 mg, 0.27 mmol), 4-fluoro-3-methylboronic acid (63 mg, 0.41 mmol), bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (9.9 mg, 0.014 mmol), sodium carbonate (86 mg, 0.82 mmol), 1,4-dioxane (1.4 mL) and water (0.8 mL) was heated at 110° C. for 16 hours. The reaction mixture was diluted with water and washed ethyl acetate (3×). The aqueous layer was acidified with 1N HCl and extracted with ethyl acetate (3×). The combined organics were dried (MgSO₄) and concentrated to afford the title compound (71 mg, 0.25 mmol, 92%) in sufficient purity for use in subsequent transformations. MS (ESI): mass calcd. for C₁₅H₁₂FN₃O₂, 285.1; m/z found, 286.1 [M+H]⁺.

Intermediate 53: 2-(6-(4-Fluoro-2-methylphenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was prepared in a manner analogous to Intermediate 52, using 4-fluoro-2-methylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₅H₁₂FN₃O₂, 285.1; m/z found, 286.1 [M+H]⁺.

Intermediate 54: Ethyl 2-(6-(3-(hydroxymethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

A mixture of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 40, 1.5 g, 5.3 mmol), (3-(hydroxymethyl)phenyl)boronic acid (1.6 g, 10.6 mmol), cesium carbonate (3.4 g, 10.6 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (270 mg, 0.4 mmol) in 1,4-dioxane (49 mL) was heated to 90° C. After 3 days, water (100 mL) was added and the mixture was extracted using EtOAc (3×150 mL). The combined organics were dried (MgSO₄), filtered and concentrated under vacuum. Purification (FCC, SiO₂, 0-90% EtOAc in hexanes) afforded the title compound (325 mg, 1.0 mmol, 20%). MS (ESI): mass calcd. for C₁₇H₁₇N₃O₃, 311.1; m/z found, 312.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.50-8.48 (m, 1H), 8.38-8.36 (m, 1H), 7.78-7.75 (m, 1H), 7.71-7.67 (m, 1H), 7.50 (t, J=7.6 Hz, 1H), 7.43-7.39 (m, 1H), 5.49 (s, 2H), 4.61 (s, 2H), 4.16 (q, J=7.1 Hz, 2H), 1.21 (t, J=7.1 Hz, 3H).

Intermediate 55: Ethyl 2-(6-(3-(fluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

Bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor®) (0.2 mL, 1.2 mmol) was added to a mixture of ethyl 2-(6-(3-(hydroxymethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 54, 300 mg, 1.0 mmol) in DCM (6.6 mL) at 0° C. under a nitrogen atmosphere. After 3 hours, the reaction mixture was slowly poured into a mixture of saturated aqueous NaHCO₃(20 mL) and DCM (20 mL) at 0° C. The mixture was extracted with DCM (3×30 mL). The combined organics were dried (MgSO₄), filtered and concentrated under vacuum to afford the title compound. MS (ESI): mass calcd. for C₁₇H₁₆FN₃O₂, 313.1; m/z found, 314.2 [M+H]⁺.

Intermediate 56: 2-(6-(3-(Fluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was prepared in a manner analogous to Intermediate 41, using ethyl 2-(6-(3-(fluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 55) in place of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate. MS (ESI): mass calcd. for C₁₅H₁₂FN₃O₂, 285.1; m/z found, 286.1 [M+H]⁺.

Intermediate 57: Ethyl 2-(6-(3,4-difluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate

The title compound was prepared in a manner analogous to Intermediate 54, using 3,4-difluorophenylboronic acid in place of (3-(hydroxymethyl)phenyl)boronic acid. MS (ESI): mass calcd. for C₁₆H₁₃F₂N₃O₂, 317.1; m/z found, 318.1 [M+H]⁺.

Intermediate 58: 2-(6-(3,4-Difluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid

The title compound was prepared in a manner analogous to Intermediate 41 using ethyl 2-(6-(3,4-difluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate (Intermediate 57) in place of ethyl 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)acetate. MS (ESI): mass calcd. for C₁₄H₉FN₃O₂, 289.1; m/z found, 290.1 [M+H]⁺.

Intermediate 59: 2-Bromo-N-cyclopropylacetamide

Bromoacetyl chloride (1 mL, 12.0 mmol) was added to a mixture of TEA (1.7 mL) and cyclopropylamine (0.8 mL, 12.0 mmol) in acetonitrile (15 mL) at −78° C. The iced reaction mixture was slowly warmed to room temperature. After 2 h, water (30 mL) was added and the mixture was extracted with DCM (3×40 mL). The combined organics were concentrated under vacuum to afford a mixture of the title compound contaminated with the chloro derivative. MS (ESI): mass calcd. for C₅H₈BrNO, 177.0; m/z found, 178.0 [M+H]⁺.

Intermediate 60: 6-(3-(Trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine

A suspension of 6-bromo-1H-pyrazolo[4,3-b]pyridine (5.0 g, 25.3 mmol), 3-(trifluoromethyl)phenylboronic acid (5.8 g, 30.3 mmol) and palladium-tetrakis(triphenylphosphine) (1.5 g, 1.3 mmol) in aqueous sodium carbonate (2M, 32.5 mL, 64.9 mmol) and 1,4-dioxane (96.9 mL) was stirred at 120° C. under a nitrogen atmosphere. After 48 hours, EtOAc was added and the mixture was washed with H₂O (2×). The organic layer was dried (Na₂SO₄) and concentrated in vacuo. The residue was purified (FCC, SiO₂, 0-50% EtOAc in heptane) to afford a yellowish solid. The solid was triturated using Et₂O and collected by filtration to provide the title compound (2.1 g, 8.0 mmol, 31.6%). MS (ESI): mass calcd. for C₁₃H₈F₃N₃, 263.1; m/z found, 264.1 [M+H]⁺.

Intermediate 61: 2-(3-(Difluoromethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

A solution of 4-bromo-2-(difluoromethyl)-1-fluorobenzene (20 g, 88.9 mmol), bis(pinacolato)diboron (24.8 g, 97.8 mmol), potassium acetate (26.2 g, 267 mmol), and [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) (3.12 g, 4.44 mmol) in 1,4-dioxane (400 mL) was purged with N₂, and the reaction mixture was stirred at 90° C. overnight. Upon completion, the reaction mixture was cooled to room temperature, filtered through Celite®, and rinsed with EtOAc. The filtrate was washed with water and brine. The combined organics were dried with Na₂SO₄, filtered and concentrated to yield a clear oil (22.1 g, 81.0 mmol, 91%), which solidified upon standing. ¹H NMR (400 MHz, Chloroform-d) δ 8.12-8.00 (m, 1H), 7.96-7.85 (m, 1H), 7.17-7.06 (m, 1H), 6.88 (t, J=54.9 Hz, 1H), 1.35 (s, 12H). MS (ESI): mass calcd. for C₁₃H₁₆BF₃O₂, 272.1; m/z found, 273.0 [M+H]⁺.

Intermediate 62: 2-(3-(1,1-Difluoroethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Step A: 4-Bromo-2-(1,1-difluoroethyl)-1-fluorobenzene

In a round bottom flask, a mixture of 1-(5-bromo-2-fluorophenyl)-1-ethanone (2.5 g, 11.5 mmol, 1 equiv) and DAST (1.9 mL, 14.4 mmol, 1.25 equiv) was heated at 60° C. for 16 h. Then a sat. aq. solution of NaHCO₃ was slowly added at 0° C. and extracted with DCM. The organic layers were combined, dried over MgSO₄, filtered, and partially concentrated (product is volatile). Purification (FCC, SiO₂, 100% DCM) afforded the title compound (3 g, 7.5 mmol, purity 60%, 65%) as a brown oil. ¹H NMR (300 MHz, CDCl₃) δ 7.73-7.61 (m, 1H), 7.60-7.48 (m, 1H), 7.02 (t, J=9.4 Hz, 1H), 1.98 (t, J=18.6 Hz, 3H).

Step B: 2-(3-(1,1-Difluoroethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

In a round bottom flask, bis(pinacolato)diboron (2.87 g, 11.3 mmol), potassium acetate (2.22 g, 22.6 mmol), and [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) (615 mg, 0.75 mmol) were added to a solution of 4-bromo-2-(1,1-difluoroethyl)-1-fluorobenzene (3 g, 7.5 mmol) in dry 1,4-dioxane (40 mL). The mixture was purged with nitrogen and stirred at 90° C. for 16 h. Then, a sat. aq. solution of NaHCO₃ was added and the mixture was extracted with EtOAc. The combined organics were dried with MgSO₄, filtered and concentrated to yield a brown oil (2.15 g, 7.53 mmol), which was used in the next step without further purification. MS (ESI): mass calcd. for C₁₄H₁₈BF₃O₂, 286.1; m/z found, 287.1 [M+H]⁺.

Intermediate 63: 2-(3-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 61 using 1-bromo-3-(difluoromethyl)benzene instead of 4-bromo-2-(difluoromethyl)-1-fluorobenzene. No mass observed.

Intermediate 64: 2-(3-(1,1-Difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 61 using 1-bromo-3-(1,1-difluoroethyl)benzene instead of 4-bromo-2-(difluoromethyl)-1-fluorobenzene. No mass observed.

Intermediate 65: 2-(3-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 61 using 1-bromo-3-(1,1-difluoroethyl)benzene instead of 4-bromo-2-(difluoromethyl)-1-fluorobenzene. MS (ESI): mass calcd. for C₁₃H₁₆BF₃O₂, 272.1; m/z found, 273.2 [M+H]⁺.

Intermediate 66: 2-(3-(Difluoromethoxy)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 61 using 4-bromo-2-(difluoromethoxy)-1-fluorobenzene instead of 4-bromo-2-(difluoromethyl)-1-fluorobenzene. MS (ESI): mass calcd. for C₁₃H₁₆BF₃O₃, 288.1; m/z found, 289.0 [M+H]⁺.

Intermediate 67: 2-(4-Chloro-3-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 61 using 4-bromo-1-chloro-2-(difluoromethoxy)benzene instead of 4-bromo-2-(difluoromethyl)-1-fluorobenzene. ¹H NMR (500 MHz, CDCl₃) δ 7.62-7.56 (m, 2H), 7.44 (d, J=7.9 Hz, 1H), 6.56 (t, J=73.6 Hz, 1H), 1.34 (s, 12H).

Intermediate 68: 2-(4-Chloro-3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 62 using 5-bromo-2-chlorobenzaldehyde instead of 1-(5-bromo-2-fluorophenyl)-1-ethanone in step A. MS (ESI): mass calcd. for C₁₃H₁₆BClF₂O₂, 288.1; m/z found, 289.1 [M+H]⁺.

Intermediate 69: 2-(4-Chloro-3-(1,1-difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The title compound was prepared in a manner analogous to Intermediate 62 using 1-(5-bromo-2-chlorophenyl)ethan-1-one instead of 1-(5-bromo-2-fluorophenyl)-1-ethanone in step A. ¹H NMR (500 MHz, CDCl₃) δ 8.02 (d, J=1.5 Hz, 1H), 7.79-7.71 (m, 1H), 7.47-7.39 (m, 1H), 2.03 (t, J=18.4 Hz, 3H), 1.34 (s, 12H).

Intermediate 70: 1-(2-(6-(3-(Trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl 4-methylbenzenesulfonate

To a solution of 1-(3-hydroxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt (Example 113, 32 mg, 0.085 mmol) in DCM (2 mL) was added triethylamine (0.06 mL, 0.42 mmol), N,N-dimethylpyridin-4-amine (1 mg, 0.0085 mmol), and 4-methylbenzenesulfonyl chloride (24 mg, 0.13 mmol). The resulting mixture was stirred at rt for 15 h. The mixture was then diluted with EtOAc (20 mL) and washed with brine (20 mL), then water (2×20 mL), and dried over Na₂SO₄ and concentrated. The residue was purified by FCC (hexanes/EtOAc, 0 to 100%) to afford the title compound (36 mg, 0.067 mmol). MS (ESI): mass calcd. for C₂₅H₂₁F₃N₄O₄S, 530.1; m/z found, 531.2 [M+H]⁺. ¹H NMR (400 MHz, Chloroform-d) δ 8.83 (d, J=1.8 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 8.10-8.04 (m, 1H), 7.90-7.85 (m, 1H), 7.85-7.79 (m, 1H), 7.78-7.73 (m, 2H), 7.73-7.68 (m, 1H), 7.67-7.60 (m, 1H), 7.40-7.32 (m, 2H), 5.15-5.01 (m, 3H), 4.38-4.29 (m, 1H), 4.28-4.19 (m, 1H), 4.19-4.12 (m, 1H), 4.04-3.94 (m, 1H), 2.46 (s, 3H).

Examples Example 1: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]ethanone

A stock solution of active ester was prepared by dissolving 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 27, 180 mg, 0.56 mmol), DIPEA (290 μL, 1.7 mmol), HOBt (113 mg, 0.84 mmol), and EDCI (161 mg, 1.04 mmol) in dry ACN (6 mL). A 1 mL aliquot (30 mg carboxylic acid, 0.93 mmol) was added to a vial containing 3-(trifluoromethyl)azetidine-3-ol (15.8 mg, 0.112 mmol). The reaction mixture was stirred overnight and purified by reverse phase HPLC (METHOD D) to afford the title compound (3.4 mg, 8%). MS (ESI): mass calcd. for C₁₉H₁₄F₆N₄O₂, 444.1; m/z found, 445.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.95-7.91 (m, 1H), 7.89-7.84 (m, 1H), 7.78-7.70 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.12 (d, J=7.2 Hz, 2H), 4.37-4.29 (m, 2H), 4.13-4.01 (m, 2H).

Example 2: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methyleneazetidin-1-yl)ethanone

A solution of 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 27, 50 mg, 0.156 mmol), 3-methyleneazetidine hydrochloride (33 mg, 0.31 mmol), (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP®) (97 mg, 0.19 mmol), and DIPEA (110 μL, 0.62 mmol) in dry DCM (2 mL) was stirred at r.t. for 30 minutes. The reaction mixture was injected directly onto a silica gel column and purified chromatographically (FCC, SiO₂, 0-10% MeOH/DCM gradient) to yield 24.9 mg (0.0669 mmol, 43% yield) of the title compound. MS (ESI): mass calcd. for C₁₉H₁₅F₃N₄O, 372.1; m/z found, 373.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.95 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.85 (m, 1H), 7.74 (d, J=5.1 Hz, 1H), 7.30 (d, J=9.3 Hz, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.12 (s, 2H), 5.10-5.01 (m, 2H), 4.63-4.55 (m, 4H).

Example 3: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone

Step A. tert-Butyl (1-(2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)(methyl)carbamate

The title compound was prepared in a manner analogous to Example 1 using tert-butyl azetidin-3-yl(methyl)carbamate in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₄H₂₆F₃N₅O₃, 489.2; m/z found, 490.0 [M+H]⁺.

Step B. 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone

tert-Butyl (1-(2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)(methyl)carbamate (151 mg, 0.309 mmol) was dissolved in 4 mL of a 1:1 mixture of trifluoroacetic acid (TFA) and DCM. The reaction mixture was stirred at r.t. for 1 hour, concentrated, partitioned between DCM and saturated aqueous NaHCO₃. The aqueous layer was extracted using DCM (2×) and the combined organics were concentrated and purified on silica gel (non-polar phase DCM, polar phase 10% NH₄OH/MeOH, 0-10% gradient) to yield the title compound (45 mg, 0.116 mmol, 37% yield). MS (ESI): mass calcd. for C₁₉H₁₈F₃N₅O, 389.1; m/z found, 390.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.84 (m, 1H), 7.78-7.71 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.08 (s, 2H), 4.32-4.16 (m, 2H), 3.89-3.70 (m, 2H), 3.66-3.55 (m, 1H), 2.37 (s, 3H).

Example 4: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-N-methyl-acetamide

To a solution of 2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone (Example 3, 36.5 mg, 0.094 mmol) and triethylamine (40 μL, 0.28 mmol) in dry DCM (1 mL) was added acetyl chloride (10 μL, 0.14 mmol). The reaction mixture was stirred at r.t. for 15 minutes, then injected directly onto a silica gel column and purified chromatographically (0-10% MeOH/DCM), yielding 28.8 mg (0.067 mmol, 71% yield) of the title compound. MS (ESI): mass calcd. for C₂₁H₂₀F₃N₅O₂, 431.2; m/z found, 432.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.95 (dd, J=1.9, 1.0 Hz, 1H), 7.91-7.83 (m, 1H), 7.79-7.64 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.33-5.19 (m, 1H), 5.13-5.00 (m, 2H), 4.39-4.21 (m, 2H), 4.19-4.02 (m, 2H), 3.01 (s, 3H), 2.10 (s, 3H).

Example 5: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

Method A.

To a mixture of 6-[3-(difluoromethyl)-4-fluoro-phenyl]-1H-pyrazolo[4,3-b]pyridine (Intermediate 16, 1.10 g, 4.18 mmol) and Cs₂CO₃ (2.05 g, 6.29 mmol) in dry DMF (22 mL) was added 2-chloro-1-(3-fluoroazetidin-1-yl)ethanone (Intermediate 1, 697 mg, 4.60 mmol) and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (3×60 mL). The combined organic layers were dried over Na₂SO₄, filtered and concentrated under reduced pressure. The residue was purified by gradient silica gel column chromatography eluting with n-heptane:EtOAc (100:0→0:100). The product was recrystallized from ethanol (20 mL) and triturated with water (20 mL) to afford the title compound (950 mg, 2.51 mmol, 60%) as a white powder. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.1 [M+H]⁺.

Method B.

A solution of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12, 8.33 g, 26.6 mmol) in dioxane (200 mL) was treated with 2-(3-(difluoromethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (8.7 g, 32 mmol), cesium carbonate (26 g, 80 mmol) and (2-dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate (RuPhos Pd G3) (1.1 g, 1.3 mmol, 5 mol %) and the reaction mixture was stirred at reflux for 16 hours. The mixture was allowed to cool to room temperature, concentrated to remove dioxane, partitioned between DCM and water, and the aqueous layer extracted using DCM (2×). The combined organics were washed with 4 N LiOH, dried (MgSO₄), filtered, and stirred overnight with SiliaMetSH thiol scavenger. Filtered through Celite®, purified on silica gel (0-10% MeOH/DCM gradient), recrystallized from hot ethanol then recrystallized from hot ethyl acetate. Isolated 4.78 g (12.6 mmol, 47% yield) of the title compound. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.43 (dd, J=2.0, 1.0 Hz, 1H), 8.37 (d, J=0.9 Hz, 1H), 8.10-8.01 (m, 2H), 7.62-7.54 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.55-5.37 (m, 1H), 5.36 (d, J=17.0 Hz, 1H), 5.32 (d, J=17.0 Hz, 1H), 4.60-4.47 (m, 1H), 4.36-4.20 (m, 2H), 4.03-3.91 (m, 1H).

Example 6: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

Method A.

To a suspension of sodium hydride (60% in mineral oil, 164 mg, 4.10 mmol) in dry DMF (8.9 mL) was added a solution of 6-[3-(difluoromethyl)-4-fluoro-phenyl]-1H-pyrazolo[4,3-b]pyridine (Intermediate 16, 900 mg, 3.42 mmol) in dry DMF (8.9 mL) at 0° C. under argon. The reaction mixture was stirred at 0° C. for 0.5 h. To the reaction mixture was added 2-chloro-N,N-dimethylacetamide (387 μL, 3.76 mmol, 1.18 g/mL). The reaction mixture was allowed to reach room temperature and stirred for 3 h. The reaction was then poured into water (20 mL) and was diluted with ethyl acetate (10 mL). The layers were separated, and the aqueous layer was extracted with ethyl acetate (2×20 mL). The combined organics were dried over Na₂SO₄, filtered, and concentrated under reduced pressure. Purification (FCC, SiO₂, 1 to 20% EtOAc/EtOH) afforded a solid that was recrystallized from ethanol (8 mL) to afford the title compound (708 mg, 2.03 mmol, 59%) as a white powder. MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O, 348.1; m/z found, 349.2 [M+H]⁺.

Method B.

To a solution of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 10, 14.0 g, 49.5 mmol) in dioxane (400 mL) were added 2-(3-(difluoromethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (16.2 g, 59.4 mmol), cesium carbonate (48.4 g, 149 mmol), and RuPhos Pd G3 (2.35 g, 2.81 mmol). The reaction mixture was stirred at reflux for 4 hours, let cool to room temperature, concentrated to ˜25 mL dioxane, and diluted with water (300 mL). The resulting precipitate was collected by filtration, then adsorbed onto Celite®, and purified by silica gel chromatography (FCC; 0-10% MeOH/DCM). The product obtained this way was recrystallized from hot ethyl acetate, then recrystallized a second time from hot ethanol. The crystals were re-dissolved in hot ethyl acetate and re-concentrated; this process was repeated 3× until all remaining traces of ethanol were removed. The product was dried in a vacuum oven at 60° C. for 72 h to yield 6.97 g (20.0 mmol, 40% yield) of the title compound. MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O, 348.1; m/z found, 349.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.87 (d, J=2.0 Hz, 1H), 8.42-8.39 (m, 1H), 8.33 (d, J=1.0 Hz, 1H), 8.08-8.01 (m, 2H), 7.60-7.54 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.53 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 7: 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

A mixture of 2-(6-bromopyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethyl-acetamide (Intermediate 10, 583 mg, 2.06 mmol), 4-fluoro-3-methylphenylboronic acid (381 mg, 2.47 mmol), sodium carbonate (655 mg, 6.18 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (196 mg, 0.268 mmol) in water (1.72 mL) and acetonitrile (11.2 mL) in a capped vial flushed with argon was stirred at 120° C. for 2 h under microwave irradiation. The reaction mixture was evaporated and the residue was purified by gradient silica gel column chromatography eluting with n-hexane:ethyl acetate:methanol (1:3:0→0:1:0→0:98:2→0:9:1). The product thus obtained from FCC was then recrystallized from ethanol (20 mL) to afford the title compound (380 mg, 1.22 mmol, 59%) as an off-white crystalline solid. MS (ESI): mass calcd. for C₁₇H₁₇FN₄O, 312.1; m/z found, 313.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.83 (d, J=1.9 Hz, 1H), 8.36-8.29 (m, 1H), 8.30 (s, 1H), 7.79-7.70 (m, 1H), 7.69-7.59 (m, 1H), 7.31 (t, J=9.1 Hz, 1H), 5.51 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H), 2.40-2.27 (m, 3H).

Example 8: N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

To a solution of 2-(6-bromopyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethyl-acetamide (Intermediate 10, 50 mg, 0.177 mmol) in degassed 1,4-dioxane (550 μL) was added 2-(tributylstannyl)-6-(trifluoromethyl)pyridine (85 mg, 0.195 mmol) and bis(triphenylphosphine)palladium(II)chloride (13.0 mg, 0.0185 mmol). The reaction mixture was stirred at 100° C. for 17 h. The reaction mixture was evaporated. Purification (FCC, SiO₂, 10 to 100% hexanes/EtOAc) afforded the title compound (35 mg, 0.100 mmol, 56%) as a white powder after triturating with diethyl ether (4 mL). MS (ESI): mass calcd. for C₁₆H₁₄F₃N₅O, 349.1; m/z found, 350.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 9.26 (d, J=1.9 Hz, 1H), 8.79-8.67 (m, 1H), 8.44 (d, J=8.1 Hz, 1H), 8.38 (s, 1H), 8.28 (t, J=7.9 Hz, 1H), 7.96 (d, J=7.7 Hz, 1H), 5.59 (s, 2H), 3.15 (s, 3H), 2.86 (s, 3H).

Example 9: 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

To a solution of 2-(6-bromopyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethanone (Intermediate 12, 400 mg, 1.28 mmol) in degassed 1,4-dioxane (24.7 mL) and water (7.38 mL) was added 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (408 mg, 1.34 mmol), potassium fluoride (223 mg, 3.84 mmol) and tetrakis(triphenylphosphine)palladium(0) (104 mg, 0.090 mmol). The reaction mixture was stirred at 80° C. for 2 h under argon. Additional 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (117 mg, 0.384 mmol), potassium fluoride (223 mg, 3.84 mmol) and tetrakis(triphenylphosphine)palladium(0) (104 mg, 0.090 mmol) were added and the reaction mixture was stirred at 80° C. for 15 h. The mixture was diluted with water (32 mL) and DCM (50 mL) and the layers were separated. The aqueous layer was extracted with DCM (2×40 mL) and the combined organics were dried over Na₂SO₄, filtered and concentrated under reduced pressure. The residue was purified by gradient silica gel column chromatography eluting with n-heptane:ethyl acetate:methanol (1:1:0→0:1:0→0:95:5). The residue obtained was recrystallized from ethanol (30 mL) to afford the title compound (288 mg, 0.701 mmol, 55%) as a white powder. MS (ESI): mass calcd. for C₁₈H₁₄ClF₃N₄O₂, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.47-8.40 (m, 1H), 8.41-8.34 (m, 1H), 7.85-7.77 (m, 2H), 7.73 (dd, J=8.4, 2.0 Hz, 1H), 7.45 (t, J=73.2 Hz, 1H), 5.61-5.34 (m, 2H), 5.31 (d, J=17.2 Hz, 1H), 4.66-4.45 (m, 1H), 4.39-4.15 (m, 2H), 4.07-3.88 (m, 1H).

Example 10: 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

A mixture of 2-(6-bromopyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethyl-acetamide (Intermediate 10, 46 mg, 0.162 mmol), 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (59 mg, 0.194 mmol), 1,1′-bis(diphenylphosphino)ferrocenepalladium (II) dichloride (12 mg, 0.0164 mmol) and K₂CO₃ (45 mg, 0.326 mmol) in degassed 1,4-dioxane (920 μL) and water (92 μL) was stirred at 80° C. for 4 h under argon. The reaction mixture was evaporated. Purification (FCC, SiO₂, 0 to 5% EtOAc/EtOH) afforded the title compound (32 mg, 0.084 mmol, 52%) as an off-white powder. MS (ESI): mass calcd. for C₁₇H₁₅ClF₂N₄O₂, 380.1; m/z found, 381.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.44-8.39 (m, 1H), 8.34 (s, 1H), 7.82-7.79 (m, 1H), 7.76 (d, J=8.6 Hz, 1H), 7.72 (dd, J=8.4, 1.9 Hz, 1H), 7.44 (t, J=73.2 Hz, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 11: N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

A mixture of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 10, 100 mg, 0.35 mmol), 3-(trifluoromethyl)phenylboronic acid (100 mg, 0.53 mmol), cesium carbonate (230 mg 0.71 mmol), PdCl₂(dppf) (18 mg, 0.07 mmol) was suspended in dioxane/water (1:1). The resulting reaction mixture was heated to 90° C. and stirred for 3 hours then cooled to room temperature and diluted with water and extracted with ethyl acetate (×3). The combined organic layers were dried using MgSO₄, filtered and concentrated under vacuum. Purification (METHOD A) afforded the title compound (95 mg, 77%). MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O, 348.1; m/z found, 349.1 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.83 (d, J=1.8 Hz, 1H), 8.32 (d, J=0.9 Hz, 1H), 7.97 (dd, J=1.9, 1.0 Hz, 1H), 7.89 (s, 1H), 7.84 (d, J=7.7 Hz, 1H), 7.70 (d, J=7.8 Hz, 1H), 7.63 (t, J=7.7 Hz, 1H), 5.31 (d, J=5.0 Hz, 2H), 3.20 (s, 3H), 3.00 (s, 3H).

Example 12: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone

To 6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 16, 31.2 mg, 0.117 mmol) stirring in DMF (1 mL) at rt was added Cs₂CO₃ (114.7 mg, 0.352 mmol) followed by 4-(2-chloroacetyl)morpholine (34.1 mg, 0.208 mmol). The reaction was stirred at rt overnight, then filtered through a 0.45 μM syringe filter and purified by prep HPLC (METHOD D). R^(e)-purification (FCC, SiO₂, 0-5% MeOH in DCM) afforded the title compound. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.88-7.82 (m, 1H), 7.78-7.69 (m, 1H), 7.31-7.24 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.29 (s, 2H), 3.72-3.56 (m, 8H).

Example 13: 1-Morpholino-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

DIPEA (0.11 mL, 0.6 mmol) was added to a stirred solution of 2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 39, 100 mg, 0.3 mmol), morpholine (40.7 mg, 0.5 mmol) and HATU (177.5 mg, 0.5 mmol) in DMF (1.4 mL) at room temperature. After 16 hours, EtOAc was added and the mixture was washed with brine (2×). The residue was purified (FCC, SiO₂, 0-10% MeOH in DCM) to afford a yellowish solid. Purification according to Method F. (Stationary phase: C18 XBridge 30×100 mm 5 um), Mobile phase: Gradient from 60% 0.1% NH₄CO₃H/NH₄OH pH 9 solution in Water, 40% CH₃CN to 43% 0.1% NH₄CO₃H/NH₄OH pH 9 solution in Water, 57% CH₃CN) afforded the title compound (55 mg, 45%). MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.84 (d, J=1.85 Hz, 1H), 8.32 (d, J=0.92 Hz, 1H), 7.98 (dd, J=1.85, 1.16 Hz, 1H), 7.89 (s, 1H), 7.84 (d, J=7.63 Hz, 1H), 7.73-7.68 (m, 1H), 7.67-7.60 (m, 1H), 5.31 (s, 2H), 3.74-3.58 (m, 8H).

Example 14: N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

6-(3-(Trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 60, 170 mg, 0.65 mmol) was dissolved in DMF (5 mL) and placed under a nitrogen atmosphere. Sodium hydride (60% dispersion in mineral oil, 78 mg, 1.94 mmol) was added and the reaction mixture was stirred for 10 minutes, at which point 2-bromo-N-cyclopropylacetamide (Intermediate 59, 230 mg, 1.29 mmol) was added. The reaction mixture was stirred at 80° C. for 5 hours, cooled to room temperature, and diluted with water. The mixture was extracted with ethyl acetate (3×), the combined organics were dried (MgSO₄) and concentrated. Purification (FCC, SiO₂, 0 to 90% EtOAc/hexanes) afforded 44.2 mg (0.123 mmol, 19% yield) of the title compound. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=2.0 Hz, 1H), 8.57-8.54 (m, 1H), 8.40-8.33 (m, 2H), 8.18-8.13 (m, 2H), 7.85-7.76 (m, 2H), 5.15 (s, 2H), 2.69-2.62 (m, 1H), 0.66-0.61 (m, 2H), 0.48-0.42 (m, 2H).

Example 15: N-(1-Methylazetidin-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

A mixture of 2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 39, 78.8 mg, 0.2 mmol), 1-methylazetidin-3-amine (25.4 mg, 0.3 mmol), HATU (102.6, 0.3 mmol) and DIPEA (0.13 mL, 0.7 mmol) in DMF (1.5 mL) was stirred at room temperature. Upon completion the reaction mixture was purified using reversed phase HPLC (METHOD C) to afford the desired product with trace impurities. The material was loaded on a catch and release column (Agilent Bond Elut SCX). The column was washed with MeOH and the filtrate was discarded. Then, the column was washed with a solution of ˜5% NH₃ in MeOH to provide title compound (28.3 mg, 0.07 mmol, 29.6%). (ESI): mass calcd. for C₁₉H₁₈F₃N₅O, 389.2; m/z found, 390.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.83-8.77 (m, 1H), 8.58-8.55 (m, 1H), 8.36-8.34 (m, 1H), 8.18-8.13 (m, 2H), 7.84-7.76 (m, 2H), 5.21 (s, 2H), 4.29-4.20 (m, 1H), 3.54 (t, J=7.0 Hz, 2H), 3.01-2.88 (m, 2H), 2.29-2.23 (s, 3H).

Example 16: 1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

A mixture of 2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 39, 78.8 mg, 0.2 mmol), 3-fluoroazetidine hydrochloride (32.8 mg, 0.3 mmol), T3P® (50% solution in DMF, 0.44 mL, 0.7 mmol), DIPEA (0.13 mL, 0.7 mmol) in DMF (2.0 mL) was stirred at room temperature. Upon completion, the reaction mixture was purified using reversed phase HPLC (METHOD C) to provide title compound (29.4 mg, 0.06 mmol, 24.3%). MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.51-8.49 (m, 1H), 8.39-8.38 (m, 1H), 8.17-8.12 (m, 2H), 7.86-7.76 (m, 2H), 5.56-5.29 (m, 3H), 4.61-4.48 (m, 1H), 4.37-4.18 (m, 2H), 4.04-3.90 (m, 1H).

Example 17: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

A mixture of 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3,3-difluoroazetidin-1-yl)ethan-1-one (Intermediate 42, 116 mg, 0.4 mmol), (2,4-difluorophenyl)boronic acid (111 mg, 0.7 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (18.0 mg, 0.02 mmol) and cesium carbonate (229.0 mg, 0.7 mmol) in 1,4-dioxane (3.2 mL) was heated to 75° C. After 16 hours, the reaction mixture was concentrated under vacuum. The crude material was purified (FCC, SiO₂, 0-90% EtOAc in hexanes) to provide title compound (29.7 mg, 0.08 mmol, 23.1%). MS (ESI): mass calcd. for C₁₇H₁₂F₄N₄O, 364.1; m/z found, 365.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.68 (t, J=1.9 Hz, 1H), 8.39 (d, J=1.0 Hz, 1H), 8.29-8.26 (m, 1H), 7.72 (td, J=8.8, 6.5 Hz, 1H), 7.52-7.45 (m, 1H), 7.33-7.27 (m, 1H), 5.41 (s, 2H), 4.74 (t, J=12.3 Hz, 2H), 4.37 (t, J=12.5 Hz, 2H).

Example 18: 1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 9 using 1-(azetidin-1-yl)-2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 14) in place of Intermediate 12 and 5-chlorothiophene-2-boronic acid in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₅H₁₂ClFN₄OS, 350.1; m/z found, 351.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.39-8.28 (m, 1H), 7.68 (d, J=4.0 Hz, 1H), 7.29 (d, J=4.0 Hz, 1H), 5.12 (s, 2H), 4.31-4.15 (m, 2H), 4.00-3.79 (m, 2H), 2.38-2.18 (m, 2H).

Example 19: 1-(Azetidin-1-yl)-2-[6-[5-(difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 9 using 1-(azetidin-1-yl)-2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 14) in place of Intermediate 12 and 2-(5-(difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 8) in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄OS, 366.1; m/z found, 367.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.99 (d, J=1.8 Hz, 1H), 8.52-8.42 (m, 1H), 7.83-7.74 (m, 1H), 7.64-7.54 (m, 1H), 7.38 (t, J=55.1 Hz, 1H), 5.15 (s, 2H), 4.30-4.15 (m, 2H), 3.99-3.84 (m, 2H), 2.36-2.19 (m, 2H).

Example 20: 1-(Azetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 9 using 1-(azetidin-1-yl)-2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 14) in place of Intermediate 12 and 4,4,5,5-tetramethyl-2-(5-(trifluoromethyl)thiophen-2-yl)-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₂F₄N₄OS, 384.1; m/z found, 385.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.01 (d, J=2.0 Hz, 1H), 8.56-8.52 (m, 1H), 7.90-7.85 (m, 2H), 5.15 (s, 2H), 4.27-4.21 (m, 2H), 3.94-3.88 (m, 2H), 2.33-2.25 (m, 2H).

Example 21: 1-(Azetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 13, using 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 31) in place of Intermediate 16 and azetidine in place of 3-(trifluoromethyl)azetidin-3-ol. MS (ESI): mass calcd. for C₁₇H₁₅FN₄O, 310.1; m/z found, 311.2 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.27 (d, J=1.0 Hz, 1H), 7.98-7.96 (m, 1H), 7.67-7.61 (m, 2H), 7.24-7.17 (m, 2H), 5.06 (s, 2H), 4.13-4.05 (m, 4H), 2.34-2.26 (m, 2H).

Example 22: 1-(Azetidin-1-yl)-2-[6-(3-chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3-chlorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₅ClN₄O, 326.1; m/z found, 327.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.90-8.89 (m, 1H), 8.47-8.45 (m, 1H), 8.36-8.34 (m, 1H), 7.93-7.89 (m, 1H), 7.84-7.79 (m, 1H), 7.61-7.56 (m, 1H), 7.55-7.51 (m, 1H), 5.26 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.31-2.22 (m, 2H).

Example 23: 1-(Azetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using azetidine in place of 3-fluoroazetidine hydrochloride, 2-(6-(3-(fluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 56) in place of Intermediate 39 and DCM in place of DMF. MS (ESI): mass calcd. for C₁₈H₁₇FN₄O, 324.1; m/z found, 325.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.41-8.40 (m, 1H), 8.35-8.34 (m, 1H), 7.89-7.82 (m, 2H), 7.63-7.58 (m, 1H), 7.54-7.50 (m, 1H), 5.54 (d, J=47.7 Hz, 2H), 5.27 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.31-2.22 (m, 2H).

Example 24: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17 using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3-(difluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₆F₂N₄O, 342.1; m/z found, 343.1 [M+H]⁺. ¹H NMR (600 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.45-8.43 (m, 1H), 8.37-8.35 (m, 1H), 8.02-7.99 (m, 2H), 7.73-7.65 (m, 2H), 7.14 (t, J=55.8 Hz, 1H), 5.27 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.30-2.23 (m, 2H).

Example 25: 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridine (Intermediate 20) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₉H₁₈F₂N₄O, 356.1; m/z found, 357.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.48-8.40 (m, 1H), 8.36 (s, 1H), 8.05-7.88 (m, 2H), 7.74-7.57 (m, 2H), 5.27 (s, 2H), 4.27-4.13 (m, 2H), 3.97-3.83 (m, 2H), 2.33-2.19 (m, 2H), 2.07 (t, J=18.9 Hz, 3H).

Example 26: 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(3-(1,1-difluoroethyl)phenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 24) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.96 (d, J=1.8 Hz, 1H), 8.53-8.42 (m, 1H), 8.06-7.88 (m, 2H), 7.75-7.60 (m, 2H), 5.16 (s, 2H), 4.30-4.15 (m, 2H), 3.98-3.82 (m, 2H), 2.36-2.18 (m, 2H), 2.06 (t, J=18.9 Hz, 3H).

Example 27: 1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using azetidine in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.52-8.50 (m, 1H), 8.38-8.36 (m, 1H), 8.18-8.12 (m, 2H), 7.85-7.76 (m, 2H), 5.27 (s, 2H), 4.20 (t, J=7.6 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.31-2.22 (m, 2H).

Example 28: 1-(Azetidin-1-yl)-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 48) in place of Intermediate 42, (3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.87 (d, J=1.9 Hz, 1H), 8.43 (d, J=2.0 Hz, 1H), 8.17-8.10 (m, 2H), 7.85-7.76 (m, 2H), 5.17 (s, 2H), 4.17 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.56 (s, 3H), 2.30-2.21 (m, 2H).

Example 29: 1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3,4-dichlorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₄Cl₂N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.91 (d, J=2.0 Hz, 1H), 8.50-8.47 (m, 1H), 8.37-8.34 (m, 1H), 8.13 (d, J=2.1 Hz, 1H), 7.87-7.79 (m, 2H), 5.25 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.31-2.22 (m, 2H).

Example 30: 1-(Azetidin-1-yl)-2-[6-(2,3-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (2,3-dichlorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₄Cl₂N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.59 (d, J=1.8 Hz, 1H), 8.39-8.37 (m, 1H), 8.22-8.20 (m, 1H), 7.79-7.76 (m, 1H), 7.56-7.49 (m, 2H), 5.23 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.30-2.20 (m, 2H).

Example 31: 1-(Azetidin-1-yl)-2-[6-(3-chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3-chloro-2-fluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₄ClFN₄O, 344.1; m/z found, 345.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.71 (t, J=1.9 Hz, 1H), 8.39-8.37 (m, 1H), 8.35-8.33 (m, 1H), 7.73-7.68 (m, 1H), 7.65-7.61 (m, 1H), 7.44-7.39 (m, 1H), 5.25 (s, 2H), 4.21 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.31-2.22 (m, 2H).

Example 32: 1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3,4-difluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₄F₂N₄O, 328.1; m/z found, 329.1 [M+H]⁺. ¹H NMR (600 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.46-8.43 (m, 1H), 8.36-8.34 (m, 1H), 7.97 (ddd, J=12.1, 7.8, 2.4 Hz, 1H), 7.73-7.68 (m, 1H), 7.66-7.60 (m, 1H), 5.25 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.30-2.23 (m, 2H).

Example 33: 1-(Azetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (2-fluoro-3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.72 (t, J=1.8 Hz, 1H), 8.41-8.36 (m, 2H), 8.03-7.98 (m, 1H), 7.93-7.88 (m, 1H), 7.60 (t, J=7.8 Hz, 1H), 5.27 (s, 2H), 4.21 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.30-2.22 (m, 2H).

Example 34: 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-(3-(1,1-difluoroethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 19) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.45-8.39 (m, 1H), 8.37-8.33 (m, 1H), 8.03-7.97 (m, 1H), 7.94 (dd, J=7.2, 2.4 Hz, 1H), 7.55 (dd, J=11.0, 8.6 Hz, 1H), 5.26 (s, 2H), 4.24-4.14 (m, 2H), 3.96-3.87 (m, 2H), 2.32-2.22 (m, 2H), 2.10 (t, J=19.2 Hz, 3H).

Example 35: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-1-(3-fluoroazetidin-1-yl)ethanone. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.48-8.40 (m, 1H), 8.40-8.32 (m, 1H), 8.13-8.00 (m, 2H), 7.64-7.52 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.27 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.36-2.17 (m, 2H).

Example 36: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethyl)-4-fluorophenyl]-3-fluoro-pyrazolo[4,3-b]pyridine (Intermediate 21) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.50-8.46 (m, 1H), 8.12-8.04 (m, 2H), 7.64-7.56 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.15 (s, 2H), 4.27-4.17 (m, 2H), 3.94-3.86 (m, 2H), 2.33-2.22 (m, 2H).

Example 37: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 32) in place of Intermediate 27 and azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.74 (d, J=1.9 Hz, 1H), 7.90-7.80 (m, 2H), 7.78-7.69 (m, 1H), 7.33-7.22 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 4.98 (s, 2H), 4.1 (dt, 4H), 2.70 (s, 3H), 2.39-2.23 (m, 2H).

Example 38: 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (4-chloro-3-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₇ClN₄O, 340.1; m/z found, 341.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.87 (d, J=1.9 Hz, 1H), 8.40-8.37 (m, 1H), 8.35-8.32 (m, 1H), 7.85-7.83 (m, 1H), 7.69-7.65 (m, 1H), 7.60-7.57 (m, 1H), 5.25 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.45 (s, 3H), 2.31-2.23 (m, 2H).

Example 39: 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 48) in place of Intermediate 42, (4-chloro-3-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₉ClN₄O, 354.1; m/z found, 355.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.9 Hz, 1H), 7.83-7.80 (m, 1H), 7.67-7.63 (m, 1H), 7.60-7.56 (m, 1H), 5.15 (s, 2H), 4.17 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.54 (s, 3H), 2.44 (s, 3H), 2.30-2.21 (m, 2H).

Example 40: 1-(Azetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (2-fluoro-3-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₇FN₄O, 324.1; m/z found, 325.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.68 (t, J=1.9 Hz, 1H), 8.36-8.34 (m, 1H), 8.27-8.24 (m, 1H), 7.47-7.42 (m, 1H), 7.41-7.37 (m, 1H), 7.29-7.24 (m, 1H), 5.24 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.90 (t, J=7.7 Hz, 2H), 2.36-2.32 (m, 3H), 2.30-2.22 (m, 2H).

Example 41: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.42-8.38 (m, 1H), 8.37-8.33 (m, 1H), 7.83 (dd, J=7.6, 2.3 Hz, 1H), 7.78-7.73 (m, 1H), 7.60 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.25 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.34-2.20 (m, 2H).

Example 42: 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(3-(difluoromethoxy)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 23) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of Intermediate 1. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O₂, 394.1; m/z found, 395.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.46-8.44 (m, 1H), 7.85 (dd, J=7.6, 2.3 Hz, 1H), 7.80-7.74 (m, 1H), 7.62 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.14 (s, 2H), 4.27-4.18 (m, 2H), 3.95-3.84 (m, 2H), 2.33-2.21 (m, 2H).

Example 43: 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[4-chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridine (Intermediate 18) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₅ClF₂N₄O₂, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.48-8.41 (m, 1H), 8.40-8.34 (m, 1H), 7.85-7.77 (m, 2H), 7.74 (dd, J=8.4, 1.9 Hz, 1H), 7.45 (t, J=73.2 Hz, 1H), 5.26 (s, 2H), 4.20 (t, J=7.6 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.34-2.20 (m, 2H).

Example 44: 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(4-chloro-3-(difluoromethoxy)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 22) in place of Intermediate 16 and 1-(azetidin-1-yl)-2-chloroethan-1-one in place of Intermediate 1. MS (ESI): mass calcd. for C₁₈H₁₄ClF₃N₄O₂, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 9.02-8.88 (m, 1H), 8.54-8.39 (m, 1H), 7.89-7.70 (m, 3H), 7.45 (t, J=73.2 Hz, 1H), 5.15 (s, 2H), 4.33-4.12 (m, 2H), 4.01-3.80 (m, 2H), 2.37-2.18 (m, 2H).

Example 45: 1-(Azetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42 and (4-fluoro-2-methoxyphenyl)boronic acid in place of 2,4-difluorophenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₇FN₄O₂, 340.1; m/z found, 341.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.60 (d, J=1.8 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 8.11-8.09 (m, 1H), 7.43 (dd, J=8.5, 6.9 Hz, 1H), 7.11 (dd, J=11.5, 2.5 Hz, 1H), 6.95 (td, J=8.4, 2.5 Hz, 1H), 5.21 (s, 2H), 4.18 (t, J=7.7 Hz, 2H), 3.89 (t, J=7.7 Hz, 2H), 3.81 (s, 3H), 2.29-2.21 (m, 2H).

Example 46: 2-[6-(3-Acetyl-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 17, using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3-acetyl-4-fluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₇FN₄O₂, 352.1; m/z found, 353.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.44-8.42 (m, 1H), 8.36-8.34 (m, 1H), 8.19-8.16 (m, 1H), 8.12-8.08 (m, 1H), 7.56 (dd, J=10.9, 8.6 Hz, 1H), 5.27 (s, 2H), 4.20 (t, J=7.6 Hz, 2H), 3.91 (t, J=7.7 Hz, 2H), 2.68 (d, J=4.1 Hz, 3H), 2.31-2.23 (m, 2H).

Example 47: 1-(Azetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17 using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 42, (3,4,5-trifluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.52-8.48 (m, 1H), 8.38-8.35 (m, 1H), 7.94-7.85 (m, 2H), 5.24 (s, 2H), 4.20 (t, J=7.7 Hz, 2H), 3.91 (t, J=7.8 Hz, 2H), 2.32-2.22 (m, 2H).

Example 48: 1-(Azetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 1-(azetidin-1-yl)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one (Intermediate 13) in place of Intermediate 10 and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₃N₅O, 361.1; m/z found, 362.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.08 (d, J=2.0 Hz, 1H), 8.91 (d, J=5.1 Hz, 1H), 8.72 (dd, J=2.0, 1.0 Hz, 1H), 8.42 (d, J=0.9 Hz, 1H), 8.38-8.35 (m, 1H), 8.23 (dd, J=5.1, 1.7 Hz, 1H), 5.29 (s, 2H), 4.26-4.16 (m, 2H), 3.95-3.88 (m, 2H), 2.32-2.23 (m, 2H).

Example 49: 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(5-chloro-2-thienyl)pyrazolo[4,3-b]pyridine (Intermediate 37) in place of Intermediate 16. MS (ESI): mass calcd. for C₁₅H₁₂ClFN₄OS, 350.0; m/z found, 351.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.87 (d, J=2.0 Hz, 1H), 8.37-8.32 (m, 1H), 8.32-8.28 (m, 1H), 7.62 (d, J=4.0 Hz, 1H), 7.27 (d, J=4.0 Hz, 1H), 5.63-5.32 (m, 1H), 5.39-5.31 (m, 1H), 5.28 (d, J=16.4 Hz, 1H), 4.65-4.46 (m, 1H), 4.40-4.16 (m, 2H), 4.08-3.87 (m, 1H).

Example 50: 2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 9 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) and 5-chlorothiophene-2-boronic acid in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₅H₁₁ClF₂N₄OS, 368.0; m/z found, 369.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.92 (d, J=1.9 Hz, 1H), 8.36-8.29 (m, 1H), 7.67 (d, J=3.9 Hz, 1H), 7.29 (d, J=3.9 Hz, 1H), 5.56-5.37 (m, 1H), 5.22 (d, J=17.1 Hz, 1H), 5.17 (d, J=17.0 Hz, 1H), 4.63-4.52 (m, 1H), 4.39-4.19 (m, 2H), 4.03-3.91 (m, 1H).

Example 51: 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 9 using Intermediate 12 and 2-(5-(difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 8) in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄OS, 366.1; m/z found, 367.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.95 (d, J=2.0 Hz, 1H), 8.42 (dd, J=2.0, 1.0 Hz, 1H), 8.36 (d, J=1.0 Hz, 1H), 7.76-7.71 (m, 1H), 7.63-7.54 (m, 1H), 7.37 (t, J=55.2 Hz, 1H), 5.56-5.37 (m, 1H), 5.35 (d, J=16.7 Hz, 1H), 5.31 (d, J=17.0 Hz, 1H), 4.62-4.50 (m, 1H), 4.40-4.19 (m, 2H), 4.05-3.92 (m, 1H).

Example 52: 2-[6-[5-(Difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 9 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) and 2-(5-(difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 8) in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₆H₁₂F₄N₄OS, 384.1; m/z found, 385.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 9.05-8.94 (m, 1H), 8.52-8.40 (m, 1H), 7.85-7.71 (m, 1H), 7.63-7.56 (m, 1H), 7.39 (t, J=55.3 Hz, 1H), 5.65-5.32 (m, 1H), 5.26 (d, J=17.2 Hz, 1H), 5.19 (d, J=17.7 Hz, 1H), 4.73-4.46 (m, 1H), 4.46-4.15 (m, 2H), 4.10-3.85 (m, 1H).

Example 53: 1-(3-Fluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 4,4,5,5-tetramethyl-2-(5-(trifluoromethyl)thiophen-2-yl)-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₂F₄N₄OS, 384.1; m/z found, 385.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.98 (d, J=2.0 Hz, 1H), 8.51-8.46 (m, 1H), 8.38 (d, J=1.0 Hz, 1H), 7.88-7.79 (m, 2H), 5.56-5.39 (m, 1H), 5.36 (d, J=16.8 Hz, 1H), 5.31 (d, J=16.8 Hz, 1H), 4.62-4.50 (m, 1H), 4.40-4.19 (m, 2H), 4.04-3.91 (m, 1H).

Example 54: 1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 9 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) and 4,4,5,5-tetramethyl-2-(5-(trifluoromethyl)thiophen-2-yl)-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₁F₅N₄OS, 402.1; m/z found, 403.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.02 (d, J=1.9 Hz, 1H), 8.56-8.49 (m, 1H), 7.91-7.82 (m, 2H), 5.58-5.37 (m, 1H), 5.25 (d, J=17.1 Hz, 1H), 5.20 (d, J=17.1 Hz, 1H), 4.65-4.52 (m, 1H), 4.41-4.19 (m, 2H), 4.06-3.91 (m, 1H).

Example 55: 1-(3-Fluoroazetidin-1-yl)-2-[6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3-fluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₂N₄O, 328.1; m/z found, 329.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.47-8.42 (m, 1H), 8.38-8.33 (m, 1H), 7.72-7.67 (m, 1H), 7.70-7.66 (m, 1H), 7.60 (dt, J=8.1, 6.2 Hz, 1H), 7.34-7.26 (m, 1H), 5.55-5.37 (m, 1H), 5.35 (d, J=17.0 Hz, 1H), 5.31 (d, J=17.1 Hz, 1H), 4.61-4.48 (m, 1H), 4.36-4.18 (m, 2H), 4.04-3.90 (m, 1H).

Example 56: 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 4-fluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₂N₄O, 328.1; m/z found, 329.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.86 (d, J=1.9 Hz, 1H), 8.36 (d, J=1.9 Hz, 1H), 8.34 (s, 1H), 7.91-7.82 (m, 2H), 7.44-7.34 (m, 2H), 5.54-5.37 (m, 1H), 5.34 (d, J=17.0 Hz, 1H), 5.30 (d, J=17.1 Hz, 1H), 4.60-4.48 (m, 1H), 4.35-4.19 (m, 2H), 4.03-3.91 (m, 1H).

Example 57: 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3-chlorophenylboronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄ClFN₄O, 344.1; m/z found, 345.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.48-8.42 (m, 1H), 8.39-8.32 (m, 1H), 7.92-7.87 (m, 1H), 7.84-7.77 (m, 1H), 7.58 (t, J=7.8 Hz, 1H), 7.55-7.49 (m, 1H), 5.55-5.36 (m, 1H), 5.36 (d, J=17.1 Hz, 1H), 5.31 (d, J=17.1 Hz, 1H), 4.60-4.49 (m, 1H), 4.35-4.19 (m, 2H), 4.04-3.90 (m, 1H).

Example 58: 1-(3-Fluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 42, m-tolylboronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₈H₁₇FN₄O, 324.1; m/z found, 325.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.86 (d, J=1.9 Hz, 1H), 8.36-8.33 (m, 2H), 7.65-7.62 (m, 1H), 7.62-7.58 (m, 1H), 7.43 (t, J=7.6 Hz, 1H), 7.30-7.25 (m, 1H), 5.54-5.28 (m, 3H), 4.60-4.50 (m, 1H), 4.35-4.20 (m, 2H), 4.02-3.92 (m, 1H), 2.42 (s, 3H).

Example 59: 1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using 2-(6-(3-(fluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 56) in place of Intermediate 39 and DCM in place of DMF. MS (ESI): mass calcd. for C₁₈H₁₆F₂N₄O, 342.1; m/z found, 343.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.41-8.39 (m, 1H), 8.36-8.35 (m, 1H), 7.88-7.82 (m, 2H), 7.64-7.58 (m, 1H), 7.54-7.49 (m, 1H), 5.60-5.29 (m, 5H), 4.59-4.50 (m, 1H), 4.36-4.20 (m, 2H), 4.04-3.92 (m, 1H).

Example 60: 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.53-8.41 (m, 1H), 8.40-8.31 (m, 1H), 8.09-7.90 (m, 2H), 7.77-7.62 (m, 2H), 7.15 (t, J=55.8 Hz, 1H), 5.62-5.32 (m, 1H), 5.38 (d, J=16.8 Hz, 1H), 5.32 (d, J=16.9 Hz, 1H), 4.64-4.45 (m, 1H), 4.40-4.15 (m, 2H), 4.08-3.85 (m, 1H).

Example 61: 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 3-(1,1-difluoroethyl)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 20) in place of Intermediate 16 and 2-chloro-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 1) in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.92 (d, J=1.9 Hz, 1H), 8.50-8.40 (m, 1H), 8.40-8.31 (m, 1H), 8.02-7.85 (m, 2H), 7.76-7.58 (m, 2H), 5.61-5.29 (m, 1H), 5.36 (d, J=17.1 Hz, 1H), 5.35 (d, J=17.2 Hz, 1H), 4.63-4.45 (m, 1H), 4.39-4.15 (m, 2H), 4.07-3.85 (m, 1H), 2.06 (t, J=18.9 Hz, 3H).

Example 62: 2-[6-[3-(Difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(3-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.45-8.39 (m, 1H), 8.39-8.33 (m, 1H), 7.74-7.67 (m, 1H), 7.65-7.57 (m, 2H), 7.37 (t, J=74.0 Hz, 1H), 7.30-7.25 (m, 1H), 5.55-5.38 (m, 1H), 5.36 (d, J=17.2 Hz, 1H), 5.31 (d, J=17.2 Hz, 1H), 4.60-4.49 (m, 1H), 4.36-4.19 (m, 2H), 4.04-3.90 (m, 1H).

Example 63: 2-[6-(2,3-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and (2,3-difluorophenyl)boronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.77-8.69 (m, 1H), 8.42-8.38 (m, 1H), 8.37-8.30 (m, 1H), 7.62-7.45 (m, 2H), 7.44-7.34 (m, 1H), 5.61-5.29 (m, 1H), 5.42-5.34 (m, 1H), 5.33 (d, J=17.1 Hz, 1H), 4.65-4.48 (m, 1H), 4.40-4.18 (m, 2H), 4.05-3.88 (m, 1H).

Example 64: 2-[6-(2,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2,4-difluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.71-8.66 (m, 1H), 8.41-8.34 (m, 1H), 8.30-8.24 (m, 1H), 7.72 (dt, J=8.8, 6.5 Hz, 1H), 7.52-7.44 (m, 1H), 7.34-7.25 (m, 1H), 5.54-5.37 (m, 1H), 5.35 (d, J=17.1 Hz, 1H), 5.30 (d, J=17.1 Hz, 1H), 4.61-4.50 (m, 1H), 4.37-4.18 (m, 2H), 4.03-3.90 (m, 1H).

Example 65: 2-[6-(3,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3,4-difluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93-8.87 (m, 1H), 8.46-8.41 (m, 1H), 8.36 (s, 1H), 8.01-7.90 (m, 1H), 7.75-7.57 (m, 2H), 5.58-5.36 (m, 1H), 5.39-5.33 (m, 1H), 5.32 (d, J=17.1 Hz, 1H), 4.64-4.46 (m, 1H), 4.38-4.17 (m, 2H), 4.05-3.90 (m, 1H).

Example 66: 2-[6-(3,5-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3,5-difluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 9.00-8.90 (m, 1H), 8.56-8.47 (m, 1H), 8.42-8.33 (m, 1H), 7.72-7.57 (m, 2H), 7.42-7.28 (m, 1H), 5.63-5.28 (m, 1H), 5.39-5.33 (m, 1H), 5.30 (d, J=17.5 Hz, 1H), 4.66-4.45 (m, 1H), 4.40-4.13 (m, 2H), 4.08-3.85 (m, 1H).

Example 67: 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3-chloro-2-fluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃ClF₂N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.74-8.69 (m, 1H), 8.40 (s, 1H), 8.37-8.31 (m, 1H), 7.75-7.67 (m, 1H), 7.67-7.59 (m, 1H), 7.45-7.37 (m, 1H), 5.59-5.36 (m, 1H), 5.39-5.33 (m, 1H), 5.33 (d, J=17.1 Hz, 1H), 4.66-4.45 (m, 1H), 4.42-4.16 (m, 2H), 4.06-3.88 (m, 1H).

Example 68: 2-[6-(3-Chloro-4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3-chloro-4-fluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃ClF₂N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.48-8.41 (m, 1H), 8.39-8.32 (m, 1H), 8.07 (dd, J=7.1, 2.3 Hz, 1H), 7.90-7.80 (m, 1H), 7.61 (t, J=9.0 Hz, 1H), 5.60-5.33 (m, 1H), 5.39-5.33 (m, 1H), 5.30 (d, J=17.3 Hz, 1H), 4.64-4.44 (m, 1H), 4.39-4.15 (m, 2H), 4.07-3.86 (m, 1H).

Example 69: 1-(3-Chloroazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-chloroazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₄ClF₃N₄O, 394.1; m/z found, 395.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.93-7.84 (m, 1H), 7.82-7.67 (m, 1H), 7.35-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.34-4.90 (m, 2H), 4.72-4.41 (m, 3H), 4.26-4.14 (m, 2H).

Example 70: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridine (Intermediate 21) in place of Intermediate 16 and 2-chloro-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 1) in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₃F₅N₄O, 396.1; m/z found, 397.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.52-8.42 (m, 1H), 8.14-8.01 (m, 2H), 7.66-7.54 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.62-5.31 (m, 1H), 5.27 (d, J=17.1 Hz, 1H), 5.20 (d, J=17.2 Hz, 1H), 4.66-4.49 (m, 1H), 4.43-4.15 (m, 2H), 4.07-3.87 (m, 1H).

Example 71: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 13 using 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 32) in place of Intermediate 27 and 3-fluoroazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.75 (d, J=1.9 Hz, 1H), 7.93-7.79 (m, 2H), 7.78-7.69 (m, 1H), 7.36-7.21 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 5.47-5.13 (m, 1H), 5.02 (s, 2H), 4.44-4.25 (m, 2H), 4.25-4.07 (m, 2H), 2.69 (s, 3H).

Example 72: 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(3-(1,1-difluoroethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.46-8.39 (m, 1H), 8.39-8.34 (m, 1H), 8.08-7.96 (m, 1H), 7.97-7.89 (m, 1H), 7.56 (dd, J=11.0, 8.6 Hz, 1H), 5.62-5.33 (m, 2H), 5.31 (d, J=16.8 Hz, 1H), 4.64-4.45 (m, 1H), 4.39-4.15 (m, 2H), 4.07-3.87 (m, 1H), 2.10 (t, J=19.1 Hz, 3H).

Example 73: 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) in place of Intermediate 10 and 2-(3-(1,1-difluoroethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.51-8.42 (m, 1H), 8.08-7.98 (m, 1H), 7.98-7.91 (m, 1H), 7.58 (dd, J=11.0, 8.6 Hz, 1H), 5.61-5.31 (m, 1H), 5.27 (d, J=17.2 Hz, 1H), 5.20 (d, J=17.2 Hz, 1H), 4.67-4.47 (m, 1H), 4.42-4.15 (m, 2H), 4.07-3.88 (m, 1H), 2.10 (t, J=19.1 Hz, 3H).

Example 74: 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(4-chloro-3-(1,1-difluoroethyl))-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₉H₁₆ClF₃N₄O, 408.1; m/z found, 409.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.49-8.41 (m, 1H), 8.38 (s, 1H), 8.04-7.98 (m, 1H), 7.99-7.90 (m, 1H), 7.77 (d, J=8.3 Hz, 1H), 5.61-5.35 (m, 2H), 5.32 (d, J=17.0 Hz, 1H), 4.66-4.46 (m, 1H), 4.40-4.14 (m, 2H), 4.07-3.88 (m, 1H), 2.13 (t, J=19.0 Hz, 3H).

Example 75: 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) in place of Intermediate 10 and 2-(4-chloro-3-(1,1-difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₉H₁₅ClF₄N₄O, 426.1; m/z found, 427.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.95 (d, J=1.8 Hz, 1H), 8.54-8.44 (m, 1H), 8.05-7.92 (m, 2H), 7.79 (d, J=8.3 Hz, 1H), 5.62-5.32 (m, 1H), 5.27 (d, J=17.0 Hz, 1H), 5.21 (d, J=17.0 Hz, 1H), 4.68-4.47 (m, 1H), 4.43-4.14 (m, 2H), 4.06-3.87 (m, 1H), 2.13 (t, J=19.0 Hz, 3H).

Example 76: 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(4-chloro-3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₄ClF₃N₄O, 394.1; m/z found, 395.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.91 (d, J=2.0 Hz, 1H), 8.48 (dd, J=2.0, 1.0 Hz, 1H), 8.38 (d, J=1.0 Hz, 1H), 8.10 (d, J=2.3 Hz, 1H), 8.06-8.01 (m, 1H), 7.82-7.77 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.56-5.37 (m, 1H), 5.39-5.35 (m, 1H), 5.33 (d, J=17.2 Hz, 1H), 4.60-4.47 (m, 1H), 4.36-4.19 (m, 2H), 4.03-3.91 (m, 1H).

Example 77: 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 42, (4-chloro-3-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid, and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₆ClFN₄O, 358.1; m/z found, 359.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.40-8.38 (m, 1H), 8.36-8.34 (m, 1H), 7.85-7.82 (m, 1H), 7.68-7.65 (m, 1H), 7.60-7.57 (m, 1H), 5.55-5.27 (m, 3H), 4.61-4.49 (m, 1H), 4.37-4.19 (m, 2H), 4.03-3.91 (m, 1H), 2.45 (s, 3H).

Example 78: 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 42 and (4-fluoro-2-methoxyphenyl)boronic acid in place of 2,4-difluorophenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₆F₂N₄O₂, 358.1; m/z found, 359.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.60 (d, J=1.8 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 8.11-8.09 (m, 1H), 7.43 (dd, J=8.4, 6.9 Hz, 1H), 7.11 (dd, J=11.5, 2.5 Hz, 1H), 6.95 (td, J=8.4, 2.5 Hz, 1H), 5.53-5.35 (m, 1H), 5.34-5.23 (m, 2H), 4.58-4.47 (m, 1H), 4.35-4.17 (m, 2H), 4.01-3.90 (m, 1H), 3.81 (s, 3H).

Example 79: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(3-(difluoromethoxy)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O₂, 394.1; m/z found, 395.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.44-8.39 (m, 1H), 8.36 (d, J=1.1 Hz, 1H), 7.83 (dd, J=7.5, 2.3 Hz, 1H), 7.78-7.71 (m, 1H), 7.60 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.54-5.38 (m, 1H), 5.33 (d, J=17.4 Hz, 1H), 5.30 (d, J=17.1 Hz, 1H), 4.59-4.50 (m, 1H), 4.35-4.19 (m, 2H), 4.03-3.91 (m, 1H).

Example 80: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) in place of Intermediate 10 and 2-(3-(difluoromethoxy)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₃F₅N₄O₂, 412.1; m/z found, 413.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.51-8.36 (m, 1H), 7.90-7.81 (m, 1H), 7.81-7.71 (m, 1H), 7.68-7.58 (m, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.62-5.30 (m, 1H), 5.26 (d, J=17.3 Hz, 1H), 5.19 (d, J=17.7 Hz, 1H), 4.68-4.46 (m, 1H), 4.44-4.15 (m, 2H), 4.07-3.86 (m, 1H).

Example 81: 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 15) in place of Intermediate 10 and 2-(4-chloro-3-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₃ClF₄N₄O₂, 428.1; m/z found, 429.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.51-8.44 (m, 1H), 7.83 (d, J=2.1 Hz, 1H), 7.80 (d, J=8.3 Hz, 1H), 7.74 (dd, J=8.4, 2.1 Hz, 1H), 7.44 (t, J=73.2 Hz, 1H), 5.56-5.35 (m, 1H), 5.25 (d, J=17.2 Hz, 1H), 5.20 (d, J=17.0 Hz, 1H), 4.64-4.52 (m, 1H), 4.39-4.19 (m, 2H), 4.04-3.91 (m, 1H).

Example 82: 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(2,4-difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.72-8.60 (m, 1H), 8.42-8.32 (m, 1H), 8.30-8.21 (m, 1H), 7.61-7.45 (m, 1H), 7.32-7.19 (m, 1H), 5.63-5.29 (m, 1H), 5.41-5.33 (m, 1H), 5.29 (d, J=17.7 Hz, 1H), 4.65-4.44 (m, 1H), 4.42-4.13 (m, 2H), 4.07-3.83 (m, 1H), 2.26 (s, 3H).

Example 83: 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 2-(3,4-difluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.43-8.38 (m, 1H), 8.37-8.33 (m, 1H), 7.79-7.71 (m, 1H), 7.64-7.58 (m, 1H), 5.54-5.37 (m, 1H), 5.34 (d, J=17.0 Hz, 1H), 5.29 (d, J=17.0 Hz, 1H), 4.60-4.48 (m, 1H), 4.36-4.19 (m, 2H), 4.04-3.92 (m, 1H), 2.43-2.38 (m, 3H).

Example 84: 1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 3,4,5-trifluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₂F₄N₄O, 364.1; m/z found, 365.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.51-8.46 (m, 1H), 8.41-8.35 (m, 1H), 7.92-7.84 (m, 2H), 5.54-5.37 (m, 1H), 5.34 (d, J=17.1 Hz, 1H), 5.29 (d, J=17.1 Hz, 1H), 4.60-4.49 (m, 1H), 4.35-4.19 (m, 2H), 4.04-3.91 (m, 1H).

Example 85: 1-(3-Fluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoroazetidin-1-yl)ethan-1-one (Intermediate 12) in place of Intermediate 10 and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₃F₄N₅O, 379.1; m/z found, 380.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.08 (d, J=2.0 Hz, 1H), 8.92 (d, J=5.1 Hz, 1H), 8.73-8.68 (m, 1H), 8.45-8.41 (m, 1H), 8.38-8.33 (m, 1H), 8.22 (dd, J=5.2, 1.7 Hz, 1H), 5.55-5.38 (m, 1H), 5.40-5.36 (m, 1H), 5.35 (d, J=17.2 Hz, 1H), 4.61-4.49 (m, 1H), 4.37-4.20 (m, 2H), 4.03-3.92 (m, 1H).

Example 86: 1-(3-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 16, using 3-methylazetidine in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.52-8.50 (m, 1H), 8.38-8.36 (m, 1H), 8.17-8.13 (m, 2H), 7.86-7.77 (m, 2H), 5.28 (s, 2H), 4.30 (t, J=8.4 Hz, 1H), 4.04-3.98 (m, 1H), 3.78-3.73 (m, 1H), 3.49-3.44 (m, 1H), 2.79-2.69 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 87: (Racemic) 1-(2-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 15, using 2-methylazetidine hydrochloride in place of 1-methylazetidin-3-amine and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.95-8.92 (m, 1H), 8.53-8.49 (m, 1H), 8.38-8.35 (m, 1H), 8.17-8.12 (m, 2H), 7.85-7.76 (m, 2H), 5.38-5.16 (m, 2H), 4.79-3.77 (m, 3H), 2.48-2.34 (m, 1H), 1.92-1.81 (m, 1H), 1.58-1.31 (m, 3H).

Example 88: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-1-(3-methylazetidin-1-yl)ethan-1-one (Intermediate 6) in place of 2-chloro-1-(3-fluoroazetidin-1-yl)ethanone. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.43 (dd, J=2.0, 1.0 Hz, 1H), 8.35 (d, J=0.9 Hz, 1H), 8.08-8.03 (m, 2H), 7.62-7.54 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.26 (s, 2H), 4.32-4.26 (m, 1H), 4.04-3.99 (m, 1H), 3.78-3.73 (m, 1H), 3.49-3.43 (m, 1H), 2.78-2.68 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 89: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 21) in place of Intermediate 10 and 2-chloro-1-(3-methylazetidin-1-yl)ethan-1-one (Intermediate 6) in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.52-8.44 (m, 1H), 8.13-8.00 (m, 2H), 7.65-7.55 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.16 (s, 2H), 4.37-4.28 (m, 1H), 4.06-3.96 (m, 1H), 3.83-3.74 (m, 1H), 3.51-3.41 (m, 1H), 2.82-2.67 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 90: (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(2-methylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-methylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82-8.76 (m, 1H), 8.33-8.26 (m, 1H), 7.98 (d, J=13.5 Hz, 1H), 7.89-7.84 (m, 1H), 7.79-7.72 (m, 1H), 7.32-7.25 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.16-4.88 (m, 2H), 4.71-4.48 (m, 1H), 4.18-3.88 (m, 2H), 2.62-2.38 (m, 1H), 1.98-1.84 (m, 1H), 1.64 (d, J=6.3 Hz, 1H), 1.45 (d, J=6.3 Hz, 2H).

Example 91: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and 2-chloro-1-(3-methylazetidin-1-yl)ethan-1-one (Intermediate 6) in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.42-8.39 (m, 1H), 8.35 (d, J=0.9 Hz, 1H), 7.83 (dd, J=7.6, 2.3 Hz, 1H), 7.78-7.73 (m, 1H), 7.60 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.25 (s, 2H), 4.33-4.26 (m, 1H), 4.05-3.97 (m, 1H), 3.79-3.73 (m, 1H), 3.49-3.44 (m, 1H), 2.78-2.68 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 92: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(3-(difluoromethoxy)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridine (Intermediate 23) in place of Intermediate 16 and 2-chloro-1-(3-methylazetidin-1-yl)ethan-1-one (Intermediate 6) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O₂, 408.1; m/z found, 409.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.51-8.38 (m, 1H), 7.89-7.82 (m, 1H), 7.82-7.72 (m, 1H), 7.62 (dd, J=10.7, 8.4 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.15 (s, 2H), 4.40-4.26 (m, 1H), 4.07-3.94 (m, 1H), 3.84-3.71 (m, 1H), 3.51-3.41 (m, 1H), 2.82-2.67 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 93: 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-(4-chloro-3-(difluoromethoxy)phenyl)-1H-pyrazolo[4,3-b]pyridine (Intermediate 22) in place of Intermediate 16 and 2-chloro-1-(3-methylazetidin-1-yl)ethan-1-one (Intermediate 6) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₆ClF₃N₄O₂, 424.1; m/z found, 425.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.95 (d, J=1.8 Hz, 1H), 8.52-8.44 (m, 1H), 7.86-7.78 (m, 2H), 7.75 (dd, J=8.4, 2.0 Hz, 1H), 7.44 (t, J=73.2 Hz, 1H), 5.15 (s, 2H), 4.38-4.27 (m, 1H), 4.06-3.94 (m, 1H), 3.84-3.74 (m, 1H), 3.51-3.41 (m, 1H), 2.82-2.67 (m, 1H), 1.21 (d, J=6.9 Hz, 3H).

Example 94: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethynylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 2 using 3-ethynylazetidine (Intermediate 33) in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₅F₃N₄O, 384.1; m/z found, 385.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.84 (m, 1H), 7.78-7.71 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.17-4.89 (m, 2H), 4.37-4.25 (m, 2H), 4.18-4.03 (m, 2H), 3.55-3.28 (m, 1H), 2.32 (d, J=2.4 Hz, 1H).

Example 95: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-vinylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 2 using 3-ethenylazetidine in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O, 386.1; m/z found, 387.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.82 (m, 1H), 7.77-7.69 (m, 1H), 7.33-7.21 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.95 (ddd, J=17.0, 10.4, 7.7 Hz, 1H), 5.16-5.08 (m, 2H), 5.07 (s, 2H), 4.31-4.18 (m, 2H), 3.96-3.82 (m, 2H), 3.37-3.24 (m, 1H).

Example 96: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-prop-1-enyl]azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 2 using (Z)-3-(prop-1-en-1-yl)azetidine (Intermediate 34) in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₁H₁₉F₃N₄O, 400.2; m/z found, 401.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.96 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.84 (m, 1H), 7.79-7.68 (m, 1H), 7.33-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.65-5.49 (m, 2H), 5.06 (t, J=1.9 Hz, 2H), 4.35-4.23 (m, 2H), 3.90-3.76 (m, 2H), 3.64-3.51 (m, 1H), 1.60-1.56 (m, 3H).

Example 97: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(fluoromethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-fluoromethylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.85 (m, 1H), 7.79-7.71 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.08 (d, J=4.0 Hz, 2H), 4.51 (dd, J=46.9, 5.2 Hz, 2H), 4.25-4.10 (m, 2H), 4.04-3.89 (m, 2H), 3.06-2.88 (m, 1H).

Example 98: 1-[3-(Difluoromethyl)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(difluoromethyl)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=0.9 Hz, 1H), 7.94 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.84 (m, 1H), 7.80-7.70 (m, 1H), 7.34-7.28 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.94 (td, J=55.9, 3.7 Hz, 1H), 5.22-4.98 (m, 2H), 4.25-3.97 (m, 4H), 3.15-2.93 (m, 1H).

Example 99: 1-[3-(Trifluoromethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 16, using 3-(trifluoromethyl)azetidine hydrochloride in place of 3-fluoroazetidine hydrochloride. MS (ESI): mass calcd. for C₁₉H₁₄F₆N₄O, 428.1; m/z found, 429.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.50-8.49 (m, 1H), 8.40-8.38 (m, 1H), 8.16-8.12 (m, 2H), 7.85-7.77 (m, 2H), 5.43-5.31 (m, 2H), 4.48 (t, J=9.1 Hz, 1H), 4.28 (dd, J=9.4, 5.4 Hz, 1H), 4.16 (t, J=9.6 Hz, 1H), 3.91 (dd, J=10.3, 5.4 Hz, 1H).

Example 100: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-trifluoromethylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₄F₆N₄O, 428.1; m/z found, 429.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.83 (m, 1H), 7.79-7.71 (m, 1H), 7.34-7.26 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.17-4.95 (m, 2H), 4.30-4.08 (m, 4H), 3.37-3.16 (m, 1H).

Example 101: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-2-fluorovinyl]azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 2 using (Z)-3-(2-fluorovinyl)azetidine (Intermediate 36) in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₆F₄N₄O, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.82 (m, 1H), 7.78-7.70 (m, 1H), 7.32-7.24 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 6.48 (ddd, J=83.3, 4.7, 1.2 Hz, 1H), 5.06 (s, 2H), 5.05-4.91 (m, 1H), 4.36-4.24 (m, 2H), 3.88 (ddd, J=30.9, 9.4, 6.2 Hz, 2H), 3.76-3.66 (m, 1H).

Example 102: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(2,2-difluorovinyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 2 using 3-(2,2-difluorovinyl)azetidine (Intermediate 35) in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₅F₅N₄O, 422.1; m/z found, 423.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.94 (dd, J=1.9, 1.0 Hz, 1H), 7.91-7.83 (m, 1H), 7.81-7.70 (m, 1H), 7.33-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.06 (s, 2H), 4.43 (ddd, J=24.2, 9.6, 1.7 Hz, 1H), 4.35-4.24 (m, 2H), 3.95-3.80 (m, 2H), 3.53-3.40 (m, 1H).

Example 103: 1-(3-Methoxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using 3-methoxyazetidine hydrochloride in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.52-8.50 (m, 1H), 8.37 (d, J=1.0 Hz, 1H), 8.17-8.12 (m, 2H), 7.86-7.75 (m, 2H), 5.40-5.25 (m, 2H), 4.42-4.35 (m, 1H), 4.30-4.23 (m, 1H), 4.13-4.01 (m, 2H), 3.72 (dd, J=10.5, 3.8 Hz, 1H), 3.23 (s, 3H).

Example 104: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxyazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-methoxyazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.94 (dd, J=2.0, 1.0 Hz, 1H), 7.86 (d, J=6.5 Hz, 1H), 7.80-7.68 (m, 1H), 7.33-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.08 (d, J=2.3 Hz, 2H), 4.29-4.13 (m, 3H), 4.00-3.88 (m, 2H), 3.28 (s, 3H).

Example 105: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethoxyazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-ethoxyazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.94 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.83 (m, 1H), 7.80-7.71 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.15-5.00 (m, 2H), 4.34-4.16 (m, 3H), 4.02-3.89 (m, 2H), 3.47-3.37 (m, 2H), 1.20 (t, J=7.0 Hz, 3H).

Example 106: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methoxymethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(methoxymethyl)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.84 (m, 1H), 7.81-7.73 (m, 1H), 7.34-7.26 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.21-4.84 (m, 2H), 4.24-4.03 (m, 2H), 3.99-3.77 (m, 2H), 3.53-3.44 (m, 2H), 3.35 (s, 3H), 2.92-2.80 (m, 1H).

Example 107: 1-[3-(Methoxymethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using 3-(methoxymethyl)azetidine hydrochloride in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.2; m/z found, 405.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=2.0 Hz, 1H), 8.51-8.49 (m, 1H), 8.38-8.36 (m, 1H), 8.17-8.13 (m, 2H), 7.85-7.77 (m, 2H), 5.28 (s, 2H), 4.23 (t, J=8.5 Hz, 1H), 3.97-3.90 (m, 2H), 3.62 (dd, J=9.7, 5.6 Hz, 1H), 3.49 (d, J=6.4 Hz, 2H), 3.28 (s, 3H), 2.92-2.82 (m, 1H).

Example 108: (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1-hydroxyethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 1-(azetidine-3-yl)ethan-1-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.37-8.24 (m, 1H), 8.01-7.92 (m, 1H), 7.92-7.83 (m, 1H), 7.83-7.68 (m, 1H), 7.34-7.22 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.17-4.92 (m, 2H), 4.20-3.76 (m, 6H), 2.60 (dtd, J=14.7, 6.1, 2.3 Hz, 1H), 1.14 (dd, J=6.3, 0.9 Hz, 3H).

Example 109: 1-[3-(Difluoromethoxy)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(difluoromethoxy)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O₂, 426.1; m/z found, 427.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.91-7.85 (m, 1H), 7.81-7.68 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 6.23 (t, J=72.3 Hz, 1H), 5.08 (d, J=1.3 Hz, 2H), 5.02-4.90 (m, 1H), 4.43-4.31 (m, 2H), 4.17-4.06 (m, 2H).

Example 110: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethoxy)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(trifluoromethoxy)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₄F₆N₄O₂, 444.1; m/z found, 445.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.85 (m, 1H), 7.79-7.71 (m, 1H), 7.30 (t, J=9.1 Hz, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.09 (d, J=2.8 Hz, 2H), 4.99-4.89 (m, 1H), 4.42-4.34 (m, 2H), 4.24-4.14 (m, 2H).

Example 111: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using azetidin-3-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95-7.92 (m, 1H), 7.89-7.84 (m, 1H), 7.78-7.71 (m, 1H), 7.32-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.08 (s, 2H), 4.73-4.63 (m, 1H), 4.34-4.27 (m, 2H), 3.98-3.89 (m, 2H).

Example 112: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 28) in place of Intermediate 27 and azetidin-3-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O₂, 394.1; m/z found, 395.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.52-8.45 (m, 1H), 8.13-8.03 (m, 2H), 7.63-7.55 (m, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.79 (d, J=5.8 Hz, 1H), 5.20 (d, J=17.0 Hz, 1H), 5.16 (d, J=16.7 Hz, 1H), 4.56-4.49 (m, 1H), 4.42-4.36 (m, 1H), 4.13-4.06 (m, 1H), 4.00-3.92 (m, 1H), 3.68-3.59 (m, 1H).

Example 113: 1-(3-Hydroxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 15, using azetidin-3-ol hydrochloride in place of 1-methylazetidin-3-amine. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.54-8.51 (m, 1H), 8.39-8.36 (m, 1H), 8.17-8.13 (m, 2H), 7.86-7.76 (m, 2H), 5.31 (d, J=2.7 Hz, 2H), 4.56-4.48 (m, 1H), 4.39-4.32 (m, 1H), 4.13-4.08 (m, 1H), 3.96-3.91 (m, 1H), 3.68-3.62 (m, 1H).

Example 114: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(hydroxymethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(hydroxymethyl)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.29 (d, J=0.9 Hz, 1H), 7.96 (dd, J=1.9, 1.0 Hz, 1H), 7.88-7.84 (m, 1H), 7.78-7.71 (m, 1H), 7.32-7.27 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 5.07 (s, 2H), 4.16 (t, J=8.6 Hz, 1H), 4.09 (dd, J=10.1, 8.6 Hz, 1H), 3.97 (dd, J=8.8, 5.4 Hz, 1H), 3.86 (dd, J=10.3, 5.5 Hz, 1H), 3.75 (d, J=5.9 Hz, 2H), 2.81 (tt, J=8.5, 5.6 Hz, 1H), 2.08 (s, 1H).

Example 115: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 4-methylthiophene-2-boronic acid pinacol ester in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₆H₁₄F₂N₄OS, 348.1; m/z found, 349.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.86 (d, J=1.9 Hz, 1H), 8.33-8.31 (m, 1H), 8.27-8.25 (m, 1H), 7.57-7.54 (m, 1H), 7.28-7.25 (m, 1H), 5.39 (s, 2H), 4.75 (t, J=12.4 Hz, 2H), 4.39 (t, J=12.5 Hz, 2H), 2.30-2.26 (m, 3H).

Example 116: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 31) in place of Intermediate 16 and 3,3-difluoroazetidine in place of 3-(trifluoromethyl)azetidin-3-ol. MS (ESI): mass calcd. for C₁₇H₁₃F₃N₄O, 346.1; m/z found, 347.1 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.83 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.89 (dd, J=1.9, 1.0 Hz, 1H), 7.66-7.60 (m, 2H), 7.25-7.18 (m, 2H), 5.14 (s, 2H), 4.42-4.26 (m, 4H).

Example 117: 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 17, using (3-chlorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₇H₁₃ClF₂N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.45-8.43 (m, 1H), 8.38-8.37 (m, 1H), 7.89 (t, J=1.8 Hz, 1H), 7.82-7.78 (m, 1H), 7.61-7.51 (m, 2H), 5.42 (s, 2H), 4.74 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.6 Hz, 2H).

Example 118: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using m-tolylboronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₆F₂N₄O, 342.1; m/z found, 343.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.89-8.83 (m, 1H), 8.39-8.31 (m, 2H), 7.66-7.56 (m, 2H), 7.44 (t, J=7.6 Hz, 1H), 7.32-7.24 (m, 1H), 5.41 (s, 2H), 4.74 (t, J=12.5 Hz, 2H), 4.38 (t, J=12.4 Hz, 2H), 2.42 (s, 3H).

Example 119: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (3-(difluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₈H₁₄F₄N₄O, 378.1; m/z found, 379.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.90 (d, J=2.0 Hz, 1H), 8.44-8.42 (m, 1H), 8.39-8.37 (m, 1H), 8.01-7.97 (m, 2H), 7.74-7.65 (m, 2H), 7.14 (t, J=55.8 Hz, 1H), 5.43 (s, 2H), 4.74 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 120: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 15, using 3,3-difluoroazetidine hydrochloride in place of 1-methylazetidin-3-amine. MS (ESI): mass calcd. for C₁₈H₁₃F₅N₄O, 396.1; m/z found, 397.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.50-8.47 (m, 1H), 8.40 (d, J=0.9 Hz, 1H), 8.16-8.11 (m, 2H), 7.86-7.77 (m, 2H), 5.43 (s, 2H), 4.73 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 121: 3-[1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]pyrazolo[4,3-b]pyridin-6-yl]benzonitrile

The title compound was prepared in a manner analogous to Example 17, using (3-cyanophenyl)boronic acid in place of 2,4-difluorophenylboronic acid, [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), and sodium carbonate in place of cesium carbonate. MS (ESI): mass calcd. for C₁₈H₁₃F₂N₅O, 353.1; m/z found, 354.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ8.98-8.93 (m, 1H), 8.52-8.49 (m, 1H), 8.41-8.39 (m, 1H), 8.34-8.31 (m, 1H), 8.21-8.16 (m, 1H), 7.97-7.92 (m, 1H), 7.81-7.73 (t, J=7.9 Hz, 1H), 5.42 (s, 2H), 4.75 (t, J=12.1 Hz, 2H), 4.39 (t, J=12.6 Hz, 2H).

Example 122: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 17, using 6-(trifluoromethyl)pyridine-2-boronic acid pinacol ester in place of 2,4-difluorophenylboronic acid and palladium-tetrakis(triphenylphosphine) in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₇H₁₂F₅N₅O, 397.1; m/z found, 398.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.28 (s, 1H), 8.74 (s, 1H), 8.48-8.41 (m, 2H), 8.29 (t, J=7.9 Hz, 1H), 7.97 (d, J=7.7 Hz, 1H), 5.48 (s, 2H), 4.77 (t, J=13.0 Hz, 2H), 4.39 (t, J=12.5 Hz, 2H).

Example 123: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (2-(trifluoromethyl)pyridin-4-yl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₂F₅N₅O, 397.1; m/z found, 398.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 9.08 (d, J=1.9 Hz, 1H), 8.94-8.91 (m, 1H), 8.70-8.67 (m, 1H), 8.46-8.44 (m, 1H), 8.37-8.34 (m, 1H), 8.23-8.20 (m, 1H), 5.45 (s, 2H), 4.75 (t, J=12.3 Hz, 2H), 4.39 (t, J=12.5 Hz, 2H).

Example 124: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-3-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (5-(trifluoromethyl)pyridin-3-yl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₂F₅N₅O, 397.1; m/z found, 398.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 9.36-9.34 (m, 1H), 9.08-9.06 (m, 1H), 9.04 (d, J=1.9 Hz, 1H), 8.66-8.63 (m, 1H), 8.62-8.59 (m, 1H), 8.44-8.42 (m, 1H), 5.43 (s, 2H), 4.74 (t, J=12.6 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 125: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (3,4-difluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₇H₁₂F₄N₄O, 364.1; m/z found, 365.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.92-8.88 (m, 1H), 8.43-8.41 (m, 1H), 8.38-8.37 (m, 1H), 7.98-7.91 (m, 1H), 7.71-7.60 (m, 2H), 5.40 (s, 2H), 4.74 (t, J=12.5 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 126: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,5-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (3,5-difluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₂F₄N₄O, 364.1; m/z found, 365.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.95 (d, J=2.0 Hz, 1H), 8.50-8.48 (m, 1H), 8.40-8.38 (m, 1H), 7.67-7.58 (m, 2H), 7.35 (tt, J=9.3, 2.4 Hz, 1H), 5.41 (s, 2H), 4.73 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.6 Hz, 2H).

Example 127: 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 17, using (3-chloro-4-fluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and palladium-tetrakis(triphenylphosphine) in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₇H₁₂ClF₃N₄O, 380.1; m/z found, 381.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.44-8.41 (m, 1H), 8.38-8.36 (m, 1H), 8.06 (dd, J=7.1, 2.3 Hz, 1H), 7.85 (ddd, J=8.6, 4.6, 2.4 Hz, 1H), 7.61 (t, J=8.9 Hz, 1H), 5.41 (s, 2H), 4.73 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 128: 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 17, using (3-chloro-2-fluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₇H₁₂ClF₃N₄O, 380.1; m/z found, 381.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.72 (t, J=1.9 Hz, 1H), 8.42-8.40 (m, 1H), 8.35-8.33 (m, 1H), 7.74-7.68 (m, 1H), 7.66-7.61 (m, 1H), 7.42 (td, J=7.9, 1.0 Hz, 1H), 5.42 (s, 2H), 4.75 (t, J=12.5 Hz, 2H), 4.37 (t, J=12.6 Hz, 2H).

Example 129: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 13, using 2-(6-(4-fluoro-3-methylphenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 52) in place of Intermediate 39 and 3,3-difluoroazetidine hydrochloride in place of morpholine. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.85 (d, J=1.9 Hz, 1H), 8.36-8.33 (m, 2H), 7.76-7.72 (m, 1H), 7.67-7.63 (m, 1H), 7.34-7.29 (m, 1H), 5.40 (s, 2H), 4.73 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.6 Hz, 2H), 2.35-2.34 (m, 3H).

Example 130: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 1, using 2-(6-(4-fluoro-2-methylphenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 53) in place of Intermediate 39 and 3,3-difluoropyrrolidine hydrochloride in place of morpholine. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.54-8.50 (m, 1H), 8.38-8.35 (m, 1H), 8.11-8.09 (m, 1H), 7.36 (dd, J=8.5, 6.0 Hz, 1H), 7.26 (dd, J=10.1, 2.8 Hz, 1H), 7.17 (td, J=8.6, 2.8 Hz, 1H), 5.38 (s, 2H), 4.72 (t, J=12.4 Hz, 2H), 4.36 (t, J=12.5 Hz, 2H), 2.27 (s, 3H).

Example 131: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (2-fluoro-3-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.2 [M+H]⁺. ¹H NMR (600 MHz, DMSO-d₆) δ 8.69 (t, J=1.9 Hz, 1H), 8.39-8.36 (m, 1H), 8.28-8.25 (m, 1H), 7.46-7.42 (m, 1H), 7.42-7.37 (m, 1H), 7.27 (t, J=7.6 Hz, 1H), 5.41 (s, 2H), 4.74 (t, J=12.4 Hz, 2H), 4.37 (t, J=12.5 Hz, 2H), 2.35-2.32 (m, 3H).

Example 132: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (2-fluoro-3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₂F₆N₄O, 414.1; m/z found, 415.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.73 (t, J=1.7 Hz, 1H), 8.43-8.42 (m, 1H), 8.38-8.36 (m, 1H), 8.04-7.98 (m, 1H), 7.94-7.88 (t, J=7.3 Hz, 1H), 7.60 (t, J=7.8 Hz, 1H), 5.43 (s, 2H), 4.75 (t, J=12.4 Hz, 2H), 4.37 (t, J=12.6 Hz, 2H).

Example 133: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (4-fluoro-3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and palladium-tetrakis(triphenylphosphine) in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₈H₁₂F₆N₄O, 414.1; m/z found, 415.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.47-8.46 (m, 1H), 8.40-8.38 (m, 1H), 8.22-8.14 (m, 2H), 7.76-7.69 (m, 1H), 5.42 (s, 2H), 4.73 (t, J=12.3 Hz, 2H), 4.38 (t, J=12.6 Hz, 2H).

Example 134: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-5-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (2-fluoro-5-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and palladium-tetrakis(triphenylphosphine) in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₈H₁₂F₆N₄O, 414.1; m/z found, 415.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.57 (t, J=2.0 Hz, 1H), 8.24-8.21 (m, 1H), 8.20-8.16 (m, 1H), 7.88-7.83 (m, 1H), 7.77-7.71 (m, 1H), 7.48 (t, J=9.4 Hz, 1H), 5.23 (s, 2H), 4.54 (t, J=12.5 Hz, 2H), 4.17 (t, J=12.5 Hz, 2H).

Example 135: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-methyl-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (2-methyl-3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and palladium-tetrakis(triphenylphosphine) in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.54 (d, J=1.8 Hz, 1H), 8.40 (d, J=1.0 Hz, 1H), 8.16-8.14 (m, 1H), 7.84-7.79 (m, 1H), 7.65-7.51 (m, 2H), 5.38 (s, 2H), 4.72 (t, J=12.4 Hz, 2H), 4.36 (t, J=12.5 Hz, 2H), 2.35-2.29 (m, 3H).

Example 136: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (4-fluoro-2-methoxyphenyl)boronic acid in place of 2,4-difluorophenylboronic acid. The reaction mixture was heated to 90° C. in place of 75° C. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.60 (d, J=1.8 Hz, 1H), 8.33 (d, J=1.0 Hz, 1H), 8.12-8.10 (m, 1H), 7.43 (dd, J=8.4, 6.9 Hz, 1H), 7.11 (dd, J=11.4, 2.5 Hz, 1H), 6.95 (td, J=8.4, 2.5 Hz, 1H), 5.37 (s, 2H), 4.72 (t, J=12.4 Hz, 2H), 4.36 (t, J=12.5 Hz, 2H), 3.81 (s, 3H).

Example 137: 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (3,4,5-trifluorophenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₇H₁₁F₅N₄O, 382.1; m/z found, 383.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.48-8.46 (m, 1H), 8.39 (d, J=1.0 Hz, 1H), 7.91-7.83 (m, 2H), 5.40 (s, 2H), 4.73 (t, J=12.4 Hz, 2H), 4.38 (t, J=12.5 Hz, 2H).

Example 138: 1-(3,3-Dimethylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 16, using 3,3-dimethylazetidine hydrochloride in place of 3-fluoroazetidine hydrochloride. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O, 388.2; m/z found, 389.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.52-8.50 (m, 1H), 8.38-8.36 (m, 1H), 8.17-8.13 (m, 2H), 7.85-7.77 (m, 2H), 5.29 (s, 2H), 3.89 (s, 2H), 3.59 (s, 2H), 1.26 (s, 6H).

Example 139: 1-(3-Fluoro-3-methyl-azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using 3-fluoro-3-methylazetidine in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.51-8.49 (m, 1H), 8.39-8.37 (m, 1H), 8.17-8.12 (m, 2H), 7.85-7.77 (m, 2H), 5.42-5.30 (m, 2H), 4.40-4.26 (m, 2H), 4.07-3.96 (m, 2H), 1.61 (d, J=22.1 Hz, 3H).

Example 140: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-dimethylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3,3-dimethylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O, 388.2; m/z found, 389.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.96 (dd, J=1.9, 1.0 Hz, 1H), 7.93-7.84 (m, 1H), 7.81-7.68 (m, 1H), 7.37-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.06 (s, 2H), 3.79 (s, 2H), 3.73 (s, 2H), 1.27 (s, 6H).

Example 141: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-fluoro-3-methylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.94 (dd, J=2.0, 1.0 Hz, 1H), 7.93-7.83 (m, 1H), 7.79-7.71 (m, 1H), 7.34-7.26 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.10 (s, 2H), 4.32-4.15 (m, 2H), 4.12-3.88 (m, 2H), 1.61 (d, J=21.4 Hz, 3H).

Example 142: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-fluoro-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 2 using 3-ethyl-3-fluoroazetidine in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₈F₄N₄O, 406.1; m/z found, 407.3 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.94 (dd, J=1.9, 1.0 Hz, 1H), 7.92-7.83 (m, 1H), 7.81-7.68 (m, 1H), 7.37-7.28 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.10 (s, 2H), 4.25-3.94 (m, 4H), 1.95-1.75 (m, 2H), 0.97 (t, J=7.4 Hz, 3H).

Example 143: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(fluoromethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-fluoro-3-(fluoromethyl)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.85 (m, 1H), 7.80-7.66 (m, 1H), 7.37-7.29 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.12 (s, 2H), 4.58 (dd, J=46.8, 18.2 Hz, 2H), 4.32-4.13 (m, 4H).

Example 144: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxy-3-methyl-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-methoxy-3-methylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.96-7.93 (m, 1H), 7.88-7.84 (m, 1H), 7.78-7.72 (m, 1H), 7.32-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.09 (s, 2H), 4.03 (dd, J=14.6, 9.7 Hz, 2H), 3.83 (ddd, J=24.8, 9.7, 1.3 Hz, 2H), 3.21 (s, 3H), 1.46 (s, 3H).

Example 145: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-hydroxy-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-ethyl-3-hydroxyazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.96-7.93 (m, 1H), 7.89-7.84 (m, 1H), 7.78-7.72 (m, 1H), 7.33-7.26 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.09 (s, 2H), 4.06-3.85 (m, 4H), 2.01 (s, 1H), 1.77 (q, J=7.4 Hz, 2H), 0.95 (t, J=7.4 Hz, 3H).

Example 146: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-hydroxy-3-methylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.2 [M+H]⁺[M+H]⁺. ¹H NMR (400 MHz, Methanol-d₄) δ 8.79 (d, J=1.8 Hz, 1H), 8.29 (d, J=0.9 Hz, 1H), 8.16 (dd, J=1.9, 1.0 Hz, 1H), 7.97-7.90 (m, 1H), 7.90-7.79 (m, 1H), 7.42-7.30 (m, 1H), 7.02 (t, J=54.8 Hz, 1H), 5.19 (s, 2H), 4.12 (s, 2H), 3.95 (s, 2H), 1.53 (s, 3H).

Example 147: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(hydroxymethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-fluoro-3-hydroxymethylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O₂, 408.1; m/z found, 409.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=2.0, 1.0 Hz, 1H), 7.87 (d, J=6.5 Hz, 1H), 7.75 (s, 1H), 7.33-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.11 (s, 2H), 4.29-4.12 (m, 4H), 3.94-3.78 (m, 2H), 1.98-1.88 (m, 1H).

Example 148: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(methoxymethyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-fluoro-3-methoxymethylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₈F₄N₄O₂, 422.1; m/z found, 423.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.84 (m, 1H), 7.80-7.71 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.11 (s, 2H), 4.28-4.07 (m, 4H), 3.60 (d, J=17.5 Hz, 2H), 3.41 (s, 3H).

Example 149: [6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-2-methyl-azetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using a diastereomeric mixture of 3-hydroxy-2-methylazetidines in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.0 [M+H]⁺. ¹H NMR (400 MHz, Chloroform-d) δ 8.81-8.77 (m, 1H), 8.32-8.27 (m, 1H), 8.00-7.92 (m, 1H), 7.89-7.83 (m, 1H), 7.78-7.71 (m, 1H), 7.31-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.21-4.93 (m, 2H), 4.78-4.11 (m, 3H), 3.96-3.75 (m, 1H), 2.59-2.06 (m, 1H), 1.50-1.35 (m, 3H).

Example 150: 1-[2-[6-[3-(Trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile

The title compound was prepared in a manner analogous to Example 16, using azetidine-3-carbonitrile hydrochloride in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₄F₃N₅O, 385.1; m/z found, 386.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.95 (d, J=1.9 Hz, 1H), 8.50-8.47 (m, 1H), 8.40-8.38 (m, 1H), 8.18-8.11 (m, 2H), 7.87-7.77 (m, 2H), 5.40-5.28 (m, 2H), 4.54-4.39 (m, 2H), 4.25-4.16 (m, 1H), 4.13-4.05 (m, 1H), 3.91-3.82 (m, 1H).

Example 151: 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile

The title compound was prepared in a manner analogous to Example 2 using 3-cyanoazetidine in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₁₉H₁₄F₃N₅O, 385.1; m/z found, 386.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.83 (d, J=1.9 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.92 (dd, J=2.0, 1.0 Hz, 1H), 7.90-7.84 (m, 1H), 7.80-7.69 (m, 1H), 7.34-7.28 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.09 (d, J=3.1 Hz, 2H), 4.44-4.17 (m, 3H), 3.58-3.42 (m, 2H).

Example 152: 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3-methyl-azetidine-3-carbonitrile

The title compound was prepared in a manner analogous to Example 1 using 3-cyano-3-methylazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₆F₃N₅O, 399.1; m/z found, 400.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.83 (d, J=1.9 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.92 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.85 (m, 1H), 7.79-7.72 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.09 (s, 2H), 4.45-4.34 (m, 2H), 3.97 (t, J=9.0 Hz, 2H), 1.67 (s, 3H).

Example 153: 1-(3-Acetylazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 1-(azetidine-3-yl)ethan-1-one in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O₂, 402.1; m/z found, 403.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.84 (m, 1H), 7.78-7.72 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.21-4.94 (m, 2H), 4.33 (dd, J=8.8, 6.0 Hz, 1H), 4.27-4.08 (m, 3H), 3.57-3.43 (m, 1H), 2.18 (s, 3H).

Example 154: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]acetamide

The title compound was prepared in a manner analogous to Example 1 using 3-acetamidoazetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₈F₃N₅O₂, 417.1; m/z found, 418.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.83 (m, 1H), 7.81-7.70 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.96 (d, J=7.1 Hz, 1H), 5.19-5.01 (m, 2H), 4.76-4.61 (m, 1H), 4.47-4.30 (m, 2H), 4.01-3.83 (m, 2H), 1.96 (s, 3H).

Example 155: 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-N,N-dimethyl-azetidine-3-carboxamide

The title compound was prepared in a manner analogous to Example 1 using N,N-dimethylazetidine-3-carboxamide in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₂₀F₃N₅O₂, 431.2; m/z found, 432.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.83 (m, 1H), 7.79-7.71 (m, 1H), 7.33-7.23 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.20-4.89 (m, 2H), 4.57-4.47 (m, 1H), 4.31-4.07 (m, 3H), 3.59 (tt, J=9.0, 6.2 Hz, 1H), 2.97 (s, 3H), 2.89 (s, 3H).

Example 156: Methyl N-[1-[2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]carbamate

The title compound was prepared in a manner analogous to Example 1 using methyl azetidin-3-ylcarbamate in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₈F₃N₅O₃, 433.1; m/z found, 434.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=2.0, 1.0 Hz, 1H), 7.91-7.85 (m, 1H), 7.80-7.73 (m, 1H), 7.33-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.12-5.07 (m, 3H), 4.58-4.45 (m, 1H), 4.41-4.31 (m, 2H), 4.03-3.83 (m, 2H), 3.68 (s, 3H).

Example 157: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-2,2,2-trifluoro-acetamide

The title compound was prepared in a manner analogous to Example 1 using 3-(2,2,2-trifluoroacetamido)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₅F₆N₅O₂, 471.1; m/z found, 472.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.89-7.85 (m, 1H), 7.79-7.73 (m, 1H), 7.33-7.26 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.24-5.00 (m, 2H), 4.82-4.63 (m, 1H), 4.57-4.29 (m, 2H), 4.16-3.97 (m, 2H).

Example 158: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]cyclopropanecarboxamide

The title compound was prepared in a manner analogous to Example 1 using N-(azetidin-3-yl)cyclopropanecarboxamide in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₂H₂₀F₃N₅O₂, 443.2; m/z found, 444.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81-8.77 (m, 1H), 8.32-8.25 (m, 1H), 7.96-7.91 (m, 1H), 7.88-7.83 (m, 1H), 7.77-7.71 (m, 1H), 7.31-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.21 (s, 2H), 3.86-3.41 (m, 4H), 3.38-3.22 (m, 4H), 2.71-2.43 (m, 1H), 2.22-1.96 (m, 1H), 1.94-1.64 (m, 1H).

Example 159: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]methanesulfonamide

The title compound was prepared in a manner analogous to Example 1 using N-(azetidin-3-yl)methanesulfonamide in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₈F₃N₅O₃S, 453.1; m/z found, 454.0 [M+H]⁺. ¹H NMR (400 MHz, Methanol-d₄) δ 8.79 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 8.15 (dd, J=1.9, 1.0 Hz, 1H), 7.96-7.89 (m, 1H), 7.88-7.81 (m, 1H), 7.35 (ddd, J=9.8, 8.6, 1.2 Hz, 1H), 7.02 (t, J=54.8 Hz, 1H), 5.18 (s, 2H), 4.59-4.49 (m, 1H), 4.42-4.27 (m, 2H), 4.24-4.16 (m, 1H), 4.04-3.95 (m, 1H), 2.96 (s, 3H).

Example 160: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylsulfonylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 3-(methylsulfonyl)azetidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₃S, 438.1; m/z found, 439.0 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.90 (d, J=2.0 Hz, 1H), 8.44 (dd, J=2.0, 1.0 Hz, 1H), 8.39 (d, J=1.0 Hz, 1H), 8.12-7.98 (m, 2H), 7.59 (t, J=9.8 Hz, 1H), 7.31 (t, J=54.1 Hz, 1H), 5.48-5.25 (m, 2H), 4.60-4.52 (m, 1H), 4.50-4.44 (m, 1H), 4.44-4.35 (m, 1H), 4.26-4.17 (m, 1H), 4.16-4.07 (m, 1H), 3.07 (s, 3H).

Example 161: 1-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]pyrrolidin-2-one

The title compound was prepared in a manner analogous to Example 1 using 1-(azetidin-3-yl)pyrrolidin-2-one in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₂H₂₀F₃N₅O₂, 443.2; m/z found, 444.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.82 (m, 1H), 7.81-7.67 (m, 1H), 7.37-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.09 (s, 2H), 5.06-4.96 (m, 1H), 4.31-4.11 (m, 4H), 3.57-3.30 (m, 2H), 2.50-2.26 (m, 2H), 2.13-2.04 (m, 2H).

Example 162: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1H-imidazol-2-yl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 2 using 2-(azetidine-3-yl)-1H-imidazole in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₁H₁₇F₃N₆O, 426.1; m/z found, 427.2. ¹H NMR (400 MHz, CDCl₃) δ 8.92-8.60 (m, 1H), 8.21 (s, 1H), 7.96 (s, 1H), 7.88-7.82 (m, 1H), 7.73 (t, J=6.7 Hz, 1H), 7.30-7.22 (m, 1H), 6.96 (t, J=54.9 Hz, 1H), 6.76 (s, 2H), 5.40-5.02 (m, 3H), 4.51-4.36 (m, 2H), 4.34-4.22 (m, 2H), 4.00-3.84 (m, 1H).

Example 163: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(4-pyridyl)azetidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 2 using 4-(azetidin-3-yl)pyridine in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₃H₁₈F₃N₅O, 437.1; m/z found, 438.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.62-8.55 (m, 2H), 8.31 (d, J=1.0 Hz, 1H), 7.98 (dd, J=2.0, 1.0 Hz, 1H), 7.91-7.84 (m, 1H), 7.81-7.68 (m, 1H), 7.36-7.25 (m, 1H), 7.21-7.15 (m, 2H), 6.98 (t, J=54.8 Hz, 1H), 5.13 (d, J=1.0 Hz, 2H), 4.56-4.43 (m, 2H), 4.13 (dt, J=10.3, 6.7 Hz, 2H), 3.83 (tt, J=8.9, 6.0 Hz, 1H).

Example 164: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-pyrimidin-4-ylazetidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 2 using 4-(azetidin-3-yl)pyrimidine in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₂H₁₇F₃N₆O, 438.1; m/z found, 439.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 9.19 (d, J=1.5 Hz, 1H), 8.80 (d, J=1.9 Hz, 1H), 8.68 (d, J=5.1 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 8.05-7.97 (m, 1H), 7.93-7.83 (m, 1H), 7.81-7.69 (m, 1H), 7.34-7.25 (m, 1H), 7.18 (dd, J=5.1, 1.4 Hz, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.23-5.04 (m, 2H), 4.47-4.38 (m, 3H), 4.33-4.24 (m, 1H), 3.96-3.85 (m, 1H).

Example 165: 1-(5-Azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 5-azaspiro[3.2]hexane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O, 386.1; m/z found, 387.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.97 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.85 (m, 1H), 7.80-7.71 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.11 (s, 2H), 4.22-4.07 (m, 4H), 0.79-0.56 (m, 4H).

Example 166: 1-(2,2-Difluoro-5-azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using 1,1-difluoro-5-azaspiro[2.3]hexane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₅F₅N₄O, 422.1; m/z found, 423.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82 (d, J=1.9 Hz, 1H), 8.31 (d, J=1.1 Hz, 1H), 7.95 (dd, J=2.0, 1.1 Hz, 1H), 7.90-7.84 (m, 1H), 7.80-7.73 (m, 1H), 7.33-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.21-5.00 (m, 2H), 4.32-4.19 (m, 2H), 4.17-4.03 (m, 2H), 1.53-1.42 (m, 2H).

Example 167: 1-(6-Azaspiro[3.3]heptan-6-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using-azaspiro[3.3]heptane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₁₉F₃N₄O, 400.2; m/z found, 401.3 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.79 (d, J=1.9 Hz, 1H), 8.29 (d, J=0.9 Hz, 1H), 7.95 (dd, J=2.0, 1.0 Hz, 1H), 7.89-7.82 (m, 1H), 7.78-7.70 (m, 1H), 7.33-7.24 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 5.05 (s, 2H), 4.05 (s, 2H), 4.00 (s, 2H), 2.22-2.04 (m, 3H), 1.91-1.70 (m, 3H).

Example 168: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-oxa-6-azaspiro[3.3]heptan-6-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using 1-oxa-6-azaspiro[3.3]heptane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O₂, 402.1; m/z found, 403.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.92 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.82 (m, 1H), 7.80-7.68 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.08 (s, 2H), 4.58-4.42 (m, 2H), 4.31-4.11 (m, 4H), 2.91-2.76 (m, 2H).

Example 169: 1-(6-Oxa-2-azaspiro[3.3]heptan-2-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 16, using 2-oxa-6-azaspiro[3.3]heptane in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O₂, 402.1; m/z found, 403.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.48-8.45 (m, 1H), 8.38-8.36 (m, 1H), 8.16-8.12 (m, 2H), 7.86-7.76 (m, 2H), 5.28 (s, 2H), 4.73-4.65 (m, 4H), 4.38 (s, 2H), 4.10 (s, 2H).

Example 170: 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 31) in place of Intermediate 16 and pyrrolidine in place of 3-(trifluoromethyl)azetidin-3-ol. MS (ESI): mass calcd. for C₁₈H₁₇FN₄O, 324.1; m/z found, 325.2 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.78 (d, J=1.9 Hz, 1H), 8.28-8.26 (m, 1H), 7.96-7.94 (m, 1H), 7.65-7.59 (m, 2H), 7.23-7.15 (m, 2H), 5.20 (s, 2H), 3.61-3.47 (m, 4H), 2.06-1.99 (m, 2H), 1.92-1.85 (m, 2H).

Example 171: 1-Pyrrolidin-1-yl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one (Intermediate 43) in place of Intermediate 42, (3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II).The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.51-8.48 (m, 1H), 8.37-8.34 (m, 1H), 8.16-8.12 (m, 2H), 7.85-7.77 (m, 2H), 5.45 (s, 2H), 3.61 (t, J=6.8 Hz, 2H), 2.00-1.93 (m, 2H), 1.85-1.77 (m, 2H).

Example 172: 2-[6-(3-Cyclopropylphenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one (Intermediate 43) in place of Intermediate 42, 2-(3-cyclopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₂₁H₂₂N₄O, 346.2; m/z found, 347.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ8.84 (d, J=1.9 Hz, 1H), 8.34-8.32 (m, 1H), 8.32-8.30 (m, 1H), 7.55-7.52 (m, 1H), 7.50-7.47 (m, 1H), 7.41 (t, J=7.7 Hz, 1H), 7.16-7.12 (m, 1H), 5.43 (s, 2H), 3.60 (t, J=6.8 Hz, 2H), 2.06-1.92 (m, 3H), 1.84-1.77 (m, 2H), 1.02-0.98 (m, 2H), 0.82-0.78 (m, 2H).

Example 173: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and 2-chloro-1-(pyrrolidin-1-yl)ethan-1-one in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.96-8.80 (m, 1H), 8.45-8.36 (m, 1H), 8.34 (s, 1H), 7.89-7.78 (m, 1H), 7.81-7.70 (m, 1H), 7.68-7.53 (m, 1H), 7.38 (t, J=73.3 Hz, 1H), 5.43 (s, 2H), 3.72-3.47 (m, 2H), 3.37-3.22 (m, 2H), 2.05-1.88 (m, 2H), 1.88-1.72 (m, 2H).

Example 174: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-1-(pyrrolidin-1-yl)ethan-1-one in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93-8.83 (m, 1H), 8.47-8.39 (m, 1H), 8.34 (s, 1H), 8.09-8.01 (m, 2H), 7.62-7.53 (m, 1H), 7.30 (t, J=55.2 Hz, 1H), 5.44 (s, 2H), 3.66-3.54 (m, 2H), 3.38-3.27 (m, 2H), 2.03-1.92 (m, 2H), 1.87-1.76 (m, 2H).

Example 175: 2-[6-(3,5-Difluoro-4-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 17, using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one (Intermediate 43) in place of Intermediate 42, (3,5-difluoro-4-methylphenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₈F₂N₄O, 356.1; m/z found, 357.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.50-8.48 (m, 1H), 8.34-8.32 (m, 1H), 7.65-7.58 (m, 2H), 5.42 (s, 2H), 3.61 (t, J=6.8 Hz, 2H), 3.31 (t, J=6.9 Hz, 2H), 2.24-2.20 (m, 3H), 2.01-1.93 (m, 2H), 1.85-1.78 (m, 2H).

Example 176: 1-[(3R)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (R)-2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoropyrrolidin-1-yl)ethan-1-one (Intermediate 45) in place of Intermediate 42, (3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.0 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.52-8.49 (m, 1H), 8.39-8.35 (m, 1H), 8.16-8.10 (m, 2H), 7.85-7.76 (m, 2H), 5.59-5.27 (m, 3H), 4.02-3.41 (m, 4H), 2.38-1.94 (m, 2H).

Example 177: 1-[(3S)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 17, using (S)-2-6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-fluoropyrrolidin-1-yl)ethan-1-one (Intermediate 44) in place of Intermediate 42, (3-(trifluoromethyl)phenyl)boronic acid in place of 2,4-difluorophenylboronic acid and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane in place of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II). The reaction mixture was heated to 90° C. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.52-8.49 (m, 1H), 8.38-8.35 (m, 1H), 8.16-8.11 (m, 2H), 7.85-7.76 (m, 2H), 5.59-5.28 (m, 3H), 4.03-3.40 (m, 4H), 2.38-1.93 (m, 2H).

Example 178: (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone

The title compound was made in an analogous manner to Example 5, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and racemic 2-chloro-1-(3-fluoropyrrolidin-1-yl)ethan-1-one (Intermediate 5) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O₂, 408.1; m/z found, 409.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.45-8.38 (m, 1H), 8.35 (s, 1H), 7.86-7.78 (m, 1H), 7.79-7.70 (m, 1H), 7.60 (dd, J=10.2, 8.8 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.63-5.22 (m, 3H), 4.10-3.23 (m, 4H), 2.41-1.89 (m, 2H).

Example 179: (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone

The title compound was made in an analogous manner to Example 5, Method A, using racemic 2-chloro-1-(3-fluoropyrrolidin-1-yl)ethan-1-one (Intermediate 5) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91-8.84 (m, 1H), 8.48-8.40 (m, 1H), 8.36 (s, 1H), 8.11-7.97 (m, 2H), 7.64-7.52 (m, 1H), 7.30 (t, J=54.2 Hz, 1H), 5.65-5.23 (m, 3H), 4.08-3.21 (m, 4H), 2.39-2.21 (m, 1H), 2.21-2.03 (m, 1H).

Example 180: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (R)-3-fluoropyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.87-8.70 (m, 1H), 8.36-8.26 (m, 1H), 7.97-7.93 (m, 1H), 7.89-7.85 (m, 1H), 7.79-7.72 (m, 1H), 7.32-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.47-5.12 (m, 3H), 4.02-3.45 (m, 4H), 2.54-1.85 (m, 2H).

Example 181: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (S)-3-fluoropyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.85-8.74 (m, 1H), 8.36-8.26 (m, 1H), 7.98-7.91 (m, 1H), 7.89-7.84 (m, 1H), 7.79-7.71 (m, 1H), 7.33-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.48-5.06 (m, 3H), 4.05-3.48 (m, 4H), 2.53-1.88 (m, 2H).

Example 182: (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone

The title compound was made in an analogous manner to Example 5, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and racemic 2-chloro-1-(3-hydroxypyrrolidin-1-yl)ethan-1-one (Intermediate 4) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₃, 406.1; m/z found, 407.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.46-8.36 (m, 1H), 8.34 (s, 1H), 7.87-7.78 (m, 1H), 7.79-7.70 (m, 1H), 7.59 (dd, J=10.2, 8.7 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.49 (d, J=17.1 Hz, 1H), 5.46-5.39 (m, 1H), 4.99 (d, J=3.3 Hz, 1H), 4.33-4.24 (m, 1H), 3.80-3.64 (m, 2H), 3.53-3.19 (m, 2H), 2.10-1.70 (m, 2H).

Example 183: (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using racemic 2-chloro-1-(3-hydroxypyrrolidin-1-yl)ethan-1-one (Intermediate 4) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O₂, 390.1; m/z found, 391.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.85 (d, J=1.9 Hz, 1H), 8.45-8.37 (m, 1H), 8.32 (s, 1H), 8.07-7.97 (m, 2H), 7.59-7.50 (m, 1H), 7.27 (t, J=54.1 Hz, 1H), 5.49-5.42 (m, 1H), 5.41-5.33 (m, 1H), 4.97 (d, J=3.2 Hz, 1H), 4.29-4.23 (m, 1H), 3.74-3.61 (m, 2H), 3.49-3.38 (m, 1H), 3.31-3.20 (m, 1H), 2.04-1.69 (m, 2H).

Example 184: (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxypyrrolidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using racemic 3-methoxypyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81-8.68 (m, 1H), 8.37-8.20 (m, 1H), 7.99-7.92 (m, 1H), 7.92-7.81 (m, 1H), 7.81-7.70 (m, 1H), 7.36-7.26 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.31-5.08 (m, 2H), 4.12-3.89 (m, 1H), 3.80-3.58 (m, 3H), 3.58-3.42 (m, 1H), 3.34 (d, J=12.3 Hz, 3H), 2.35-1.87 (m, 2H).

Example 185: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (R)-2-(methoxymethyl)pyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₂₁F₃N₄O₂, 418.2; m/z found, 419.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.84-8.71 (m, 1H), 8.35-8.23 (m, 1H), 7.97-7.90 (m, 1H), 7.90-7.83 (m, 1H), 7.75 (s, 1H), 7.26 (s, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.56-5.10 (m, 2H), 4.33 (d, J=61.3 Hz, 1H), 3.75-3.23 (m, 7H), 2.29-1.77 (m, 4H).

Example 186: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (S)-2-(methoxymethyl)pyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₂₁F₃N₄O₂, 418.2; m/z found, 419.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.84-8.70 (m, 1H), 8.35-8.25 (m, 1H), 7.97-7.89 (m, 1H), 7.89-7.84 (m, 1H), 7.80-7.68 (m, 1H), 7.33-7.24 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.53-5.14 (m, 2H), 4.44-4.20 (m, 1H), 3.75-3.19 (m, 7H), 2.26-1.76 (m, 4H).

Example 187: N-[(3S)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide

The title compound was prepared in a manner analogous to Example 1 using (S)-3-acetamidopyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₂₀F₃N₅O₂, 431.2; m/z found, 432.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82-8.78 (m, 1H), 8.34-8.29 (m, 1H), 7.96-7.90 (m, 1H), 7.89-7.81 (m, 1H), 7.79-7.71 (m, 1H), 7.32-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.71-5.58 (m, 1H), 5.37-5.10 (m, 2H), 4.64-4.43 (m, 1H), 4.02-3.36 (m, 5H), 2.43-1.79 (m, 4H).

Example 188: N-[(3R)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide

The title compound was prepared in a manner analogous to Example 1 using (R)-3-acetamidopyrrolidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₂₀F₃N₅O₂, 431.2; m/z found, 432.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81-8.78 (m, 1H), 8.32-8.28 (m, 1H), 7.94-7.90 (m, 1H), 7.88-7.85 (m, 1H), 7.78-7.70 (m, 1H), 7.35-7.28 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.74-5.62 (m, 1H), 5.36-5.10 (m, 2H), 4.60-4.45 (m, 1H), 3.99-3.39 (m, 5H), 2.39-1.80 (m, 4H).

Example 189: 1-(3,3-Difluoropyrrolidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 13, using 3,3-difluoropyrrolidine hydrochloride in place of morpholine. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.84 (d, J=1.16 Hz, 1H), 8.32 (s, 1H), 7.97 (br. s, 1H), 7.89 (s, 1H), 7.84 (d, J=7.63 Hz, 1H), 7.74-7.68 (m, 1H), 7.67-7.60 (m, 1H), 5.30-5.14 (m, 2H), 4.05-3.70 (m, 4H), 2.61-2.29 (m, 2H).

Example 190: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and 2-chloro-1-(3,3-difluoropyrrolidin-1-yl)ethan-1-one (Intermediate 3) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O₂, 426.1; m/z found, 427.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.43-8.32 (m, 1H), 8.36 (s, 1H), 7.87-7.77 (m, 1H), 7.78-7.68 (m, 1H), 7.66-7.55 (m, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.59-5.49 (m, 1H), 5.51-5.38 (m, 1H), 4.24-4.09 (m, 1H), 4.01-3.85 (m, 1H), 3.82-3.65 (m, 1H), 3.63-3.49 (m, 1H), 2.71-2.50 (m, 1H), 2.49-2.30 (m, 1H).

Example 191: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-1-(3,3-difluoropyrrolidin-1-yl)ethan-1-one (Intermediate 3) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.43-8.38 (m, 1H), 8.36 (s, 1H), 8.07-8.01 (m, 2H), 7.61-7.55 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.54, 5.47 (s, 2H), 4.20-4.12, 3.78-3.70 (m, 2H), 3.92, 3.56 (t, J=7.4 Hz, 2H), 2.62-2.38 (m, 2H)* mixture of rotamers.

Example 192: (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using racemic 3-methylpyrrolidin-3-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O₂, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81-8.72 (m, 1H), 8.34-8.22 (m, 1H), 8.00-7.92 (m, 1H), 7.90-7.85 (m, 1H), 7.79-7.69 (m, 1H), 7.33-7.27 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.33-5.09 (m, 2H), 3.91-3.77 (m, 1H), 3.74-3.59 (m, 2H), 3.57-3.28 (m, 1H), 2.22-1.81 (m, 2H), 1.52-1.44 (m, 3H).

Example 193: (Racemic) Trans-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-4-hydroxy-pyrrolidin-1-yl)ethanone

The title compound was prepared in a manner analogous to Example 1 using racemic trans-4-fluoropyrrolidin-3-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₆F₄N₄O₂, 408.1; m/z found, 409.1 [M+H]⁺. ¹H NMR (400 MHz, Methanol-d₄) δ 8.78 (d, J=1.9 Hz, 1H), 8.29 (t, J=0.9 Hz, 1H), 8.25-8.16 (m, 1H), 7.98-7.92 (m, 1H), 7.92-7.84 (m, 1H), 7.41-7.29 (m, 1H), 7.02 (t, J=54.8 Hz, 1H), 5.50-5.29 (m, 2H), 5.20-4.87 (m, 1H), 4.54-4.32 (m, 1H), 4.11-3.55 (m, 5H)* mixture of trans.

Example 194: 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one

The title compound was prepared in a manner analogous to Example 1 using pyrrolidin-3-one in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₅F₃N₄O₂, 388.1; m/z found, 389.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.43-8.36 (m, 1H), 8.38-8.34 (m, 1H), 8.08-8.00 (m, 2H), 7.61-7.54 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.46 (s, 2H), 4.16 (s, 2H), 3.77-3.70 (m, 2H), 2.60 (t, J=7.9 Hz, 2H).

Example 195: 1-[2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(3-(difluoromethoxy)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 29) in place of Intermediate 27 and pyrrolidin-3-one in place of 3-(trifluoromethyl)azetidine-3-. MS (ESI): mass calcd. for C₁₉H₁₅F₃N₄O₃, 404.1; m/z found, 405.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.40-8.33 (m, 2H), 7.84-7.79 (m, 1H), 7.77-7.71 (m, 1H), 7.60 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.45 (s, 2H), 4.16 (s, 2H), 3.76-3.70 (m, 2H), 2.61 (t, J=7.9 Hz, 2H).

Example 196: 1-(1-Piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone trifluoroacetate salt

The title compound was prepared in a manner analogous to Example 16, using piperidine in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O, 388.2; m/z found, 389.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.92 (d, J=2.0 Hz, 1H), 8.48-8.46 (m, 1H), 8.35-8.34 (m, 1H), 8.16-8.11 (m, 2H), 7.84-7.76 (m, 2H), 5.55 (s, 2H), 3.43-3.39 (m, 2H), 1.66-1.57 (m, 4H), 1.51-1.40 (s, 2H).

Example 197: 1-(4,4-Difluoro-1-piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 13, using 4,4-difluoropiperidine in place of morpholine. MS (ESI): mass calcd. for C₂₀H₁₇F₅N₄O, 424.1; m/z found, 425.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.84 (d, J=1.85 Hz, 1H), 8.33 (d, J=0.92 Hz, 1H), 7.98 (dd, J=1.85, 0.92 Hz, 1H), 7.89 (s, 1H), 7.84 (d, J=7.63 Hz, 1H), 7.74-7.68 (m, 1H), 7.67-7.60 (m, 1H), 5.34 (s, 2H), 3.86-3.78 (m, 2H), 3.74 (t, J=5.90 Hz, 2H), 2.07-1.86 (m, 4H).

Example 198: N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-4-piperidyl]acetamide

The title compound was prepared in a manner analogous to Example 1 using 4-acetamidopiperidine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₂H₂₂F₃N₅O₂, 445.2; m/z found, 446.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.90-7.81 (m, 1H), 7.77-7.72 (m, 1H), 7.34-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.44-5.14 (m, 3H), 4.55-4.40 (m, 1H), 4.21-4.10 (m, 1H), 4.04-3.95 (m, 1H), 3.35-3.20 (m, 1H), 2.85-2.72 (m, 1H), 2.14-1.89 (m, 5H), 1.32-1.15 (m, 2H).

Example 199: 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 31) in place of Intermediate 16 and morpholine in place of 3-(trifluoromethyl)azetidin-3-ol. MS (ESI): mass calcd. for C₁₈H₁₇FN₄O₂, 340.1; m/z found, 341.2 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.28 (d, J=1.1 Hz, 1H), 7.93 (dd, J=1.9, 1.0 Hz, 1H), 7.65-7.59 (m, 2H), 7.23-7.17 (m, 2H), 5.28 (s, 2H), 3.72-3.59 (m, 8H).

Example 200: 1-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-3-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (1R,5S)-3-azabicyclo[3.1.0]hexane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O, 386.1; m/z found, 387.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.78 (d, J=1.9 Hz, 1H), 8.29 (d, J=1.0 Hz, 1H), 7.96-7.89 (m, 1H), 7.89-7.80 (m, 1H), 7.78-7.70 (m, 1H), 7.35-7.26 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 5.16 (d, J=2.3 Hz, 2H), 3.87-3.74 (m, 2H), 3.68 (dd, J=9.9, 4.3 Hz, 1H), 3.45 (dd, J=12.0, 4.5 Hz, 1H), 1.66 (tt, J=7.9, 4.2 Hz, 1H), 1.59 (dd, J=8.0, 4.1 Hz, 1H), 0.83-0.76 (m, 1H), 0.20 (q, J=4.5 Hz, 1H).

Example 201: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O₂, 402.1; m/z found, 403.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.83-8.76 (m, 1H), 8.33-8.26 (m, 1H), 8.04-7.90 (m, 1H), 7.89-7.85 (m, 1H), 7.79-7.72 (m, 1H), 7.33-7.26 (m, 1H), 7.14-6.79 (m, 1H), 5.34-5.07 (m, 2H), 4.98-4.81 (m, 1H), 4.76-4.63 (m, 1H), 3.97-3.38 (m, 4H), 2.03-1.79 (m, 2H).

Example 202: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone

The title compound was prepared in a manner analogous to Example 1 using (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₇F₃N₄O₂, 402.1; m/z found, 403.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.83-8.77 (m, 1H), 8.31-8.28 (m, 1H), 8.04-7.91 (m, 1H), 7.89-7.84 (m, 1H), 7.80-7.70 (m, 1H), 7.32-7.26 (m, 1H), 7.14-6.81 (m, 1H), 5.33-5.09 (m, 2H), 4.97-4.79 (m, 1H), 4.76-4.62 (m, 1H), 3.92-3.74 (m, 2H), 3.70-3.53 (m, 1H), 3.51-3.37 (m, 1H), 2.01-1.78 (m, 2H).

Example 203: (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3a,4,6,6a-tetrahydro-3H-pyrrolo[3,4-d]oxazol-2-one

The title compound was prepared in a manner analogous to Example 2 using racemic cis-hexahydro-2H-pyrrolo[3,4-d]oxazol-2-one in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₀H₁₆F₃N₅O₃, 431.1; m/z found, 432.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.72 (d, J=1.9 Hz, 1H), 8.27-8.13 (m, 2H), 7.97-7.83 (m, 3H), 7.33 (t, J=9.3 Hz, 1H), 7.02 (t, J=54.5 Hz, 1H), 5.63-4.96 (m, 3H), 4.41 (dd, J=48.3, 6.4 Hz, 2H), 3.97-3.71 (m, 3H)* cis.

Example 204: (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-2-one

The title compound was prepared in a manner analogous to Example 2 using racemic cis-hexahydropyrrolo[3,4-b]pyrrol-2(1H)-one in place of 3-methyleneazetidine. MS (ESI): mass calcd. for C₂₁H₁₈F₃N₅O₂, 429.1; m/z found, 430.2 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 10.47 (s, 1H), 8.73 (s, 1H), 8.29-8.21 (m, 1H), 8.13-8.05 (m, 1H), 7.90-7.65 (m, 2H), 7.29-7.23 (m, 1H), 7.15-6.79 (m, 1H), 5.48-5.10 (m, 2H), 4.30 (dt, J=46.8, 5.8 Hz, 1H), 4.09-3.99 (m, 1H), 3.80 (dd, J=12.9, 9.7 Hz, 1H), 3.28-2.95 (m, 3H), 2.71-2.53 (m, 1H), 2.35-2.10 (m, 1H).

Example 205: 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 9 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 10) in place of Intermediate 12 and 2-(5-(difluoromethyl)thiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Intermediate 8) in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₅H₁₄F₂N₄OS, 336.1; m/z found, 337.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=2.0 Hz, 1H), 8.47-8.37 (m, 1H), 8.36-8.28 (m, 1H), 7.77-7.68 (m, 1H), 7.62-7.53 (m, 1H), 7.37 (t, J=55.4 Hz, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.86 (s, 3H).

Example 206: N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 7 using 4,4,5,5-tetramethyl-2-(5-(trifluoromethyl)thiophen-2-yl)-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₅H₁₃F₃N₄OS, 354.1; m/z found, 355.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.96 (d, J=1.9 Hz, 1H), 8.52-8.45 (m, 1H), 8.35 (s, 1H), 7.89-7.76 (m, 2H), 5.52 (s, 2H), 3.14 (s, 3H), 2.86 (s, 3H).

Example 207: 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 9 using 2-(6-bromo-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 10) in place of Intermediate 12 and 5-chlorothiophene-2-boronic acid in place of 2-[4-chloro-3-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. MS (ESI): mass calcd. for C₁₄H₁₃ClN₄OS, 320.1; m/z found, 321.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.85 (d, J=1.9 Hz, 1H), 8.35-8.23 (m, 2H), 7.61 (d, J=4.0 Hz, 1H), 7.26 (d, J=4.0 Hz, 1H), 5.50 (s, 2H), 3.13 (s, 3H), 2.86 (s, 3H).

Example 208: 2-[6-(5-Chloro-4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was prepared in a manner analogous to Example 11 using 2-(5-chloro-4-methylthiophene-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 3-(trifluoromethyl)phenylboronic acid. MS (ESI): mass calcd. for C₁₅H₁₅ClN₄OS, 334.1; m/z found, 335.1 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.75 (d, J=1.9 Hz, 1H), 8.24 (d, J=1.0 Hz, 1H), 7.80 (dd, J=2.0, 1.0 Hz, 1H), 7.12 (s, 1H), 5.24 (s, 2H), 3.17 (s, 3H), 2.99 (s, 3H), 2.23 (s, 3H).

Example 209: 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was prepared in a manner analogous to Example 11 using 3-(difluoromethyl)phenylboronic acid in place of 3-(trifluoromethyl)phenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₆F₂N₄O, 330.1; m/z found, 331.0 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.83 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.1 Hz, 1H), 7.95 (dd, J=1.9, 1.0 Hz, 1H), 7.80-7.74 (m, 2H), 7.63-7.54 (m, 2H), 6.86-6.63 (m, 1H), 5.30 (s, 2H), 3.19 (s, 3H), 2.99 (s, 3H).

Example 210: 2-[6-[3-(Difluoromethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 2-(3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O, 348.1; m/z found, 349.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.93 (d, J=1.8 Hz, 1H), 8.51-8.42 (m, 1H), 8.06-7.95 (m, 2H), 7.77-7.64 (m, 2H), 7.14 (t, J=55.7 Hz, 1H), 5.43 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H).

Example 211: 2-[3-Fluoro-6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 4-fluorophenylboronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₄F₂N₄O, 316.1; m/z found, 317.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.8 Hz, 1H), 8.42-8.36 (m, 1H), 7.91-7.83 (m, 2H), 7.45-7.35 (m, 2H), 5.40 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H).

Example 212: 2-[3-Fluoro-6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 3-fluorophenylboronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₄F₂N₄O, 316.1; m/z found, 317.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.95 (d, J=1.8 Hz, 1H), 8.52-8.44 (m, 1H), 7.76-7.66 (m, 2H), 7.65-7.55 (m, 1H), 7.38-7.27 (m, 1H), 5.41 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H).

Example 213: 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 3-chlorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₅ClN₄O, 314.1; m/z found, 315.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.43 (dd, J=2.0, 1.0 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.91-7.88 (m, 1H), 7.82-7.78 (m, 1H), 7.57 (t, J=7.8 Hz, 1H), 7.54-7.50 (m, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 214: N,N-Dimethyl-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 7 using 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₄F₃N₅O, 349.1; m/z found, 350.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 9.07 (d, J=2.0 Hz, 1H), 8.91 (d, J=5.2 Hz, 1H), 8.74-8.63 (m, 1H), 8.42-8.37 (m, 1H), 8.37-8.32 (m, 1H), 8.26-8.16 (m, 1H), 5.56 (s, 2H), 3.15 (s, 3H), 2.86 (s, 3H).

Example 215: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-N-methylacetamide in place of Intermediate 1. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄O, 334.1; m/z found, 335.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.55-8.46 (m, 1H), 8.35 (s, 1H), 8.17-8.01 (m, 3H), 7.63-7.51 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.19 (s, 2H), 2.62 (d, J=4.6 Hz, 3H).

Example 216: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-acetamide

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-N-ethylacetamide in place of Intermediate 1. MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O, 348.1; m/z found, 349.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.54-8.46 (m, 1H), 8.38-8.31 (m, 1H), 8.23 (t, J=5.6 Hz, 1H), 8.12-8.01 (m, 2H), 7.64-7.52 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.18 (s, 2H), 3.18-3.03 (m, 2H), 1.04 (t, J=7.2 Hz, 3H).

Example 217: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methylethanamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₇F₃N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.78 (d, J=1.9 Hz, 1H), 8.30 (dd, J=2.4, 1.0 Hz, 1H), 7.92 (ddd, J=16.9, 2.0, 1.0 Hz, 1H), 7.89-7.83 (m, 1H), 7.79-7.72 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.38-5.23 (m, 2H), 3.63-3.40 (m, 2H), 3.20-2.91 (m, 3H), 1.33-1.06 (m, 3H).

Example 218: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 2-(3-(difluoromethyl)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₄N₄O, 366.1; m/z found, 367.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.48-8.38 (m, 1H), 8.10-7.97 (m, 2H), 7.60-7.53 (m, 1H), 7.28 (t, J=54.1 Hz, 1H), 5.39 (s, 2H), 3.07 (s, 3H), 2.81 (s, 3H).

Example 219: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 32) in place of Intermediate 27 and dimethylamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₇F₃N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.72 (d, J=1.9 Hz, 1H), 7.88-7.79 (m, 2H), 7.77-7.69 (m, 1H), 7.26 (s, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.22 (s, 2H), 3.18 (s, 3H), 2.99 (s, 3H), 2.70 (s, 3H).

Example 220: 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(4-chloro-3-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₅ClF₂N₄O, 364.1; m/z found, 365.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.89 (d, J=2.0 Hz, 1H), 8.45 (dd, J=2.0, 1.0 Hz, 1H), 8.34 (d, J=1.0 Hz, 1H), 8.08 (d, J=2.2 Hz, 1H), 8.05-8.00 (m, 1H), 7.81-7.76 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.54 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 221: 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(1,1-difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 19) in place of Intermediate 16. MS (ESI): mass calcd. for C₁₈H₁₇F₃N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.87 (d, J=1.9 Hz, 1H), 8.43-8.36 (m, 1H), 8.36-8.30 (m, 1H), 8.04-7.96 (m, 1H), 7.92 (dd, J=7.2, 2.3 Hz, 1H), 7.55 (dd, J=11.0, 8.6 Hz, 1H), 5.53 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H), 2.09 (t, J=19.2 Hz, 3H).

Example 222: 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was made in a manner analogous to Example 5, Method A, using 6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridine (Intermediate 25) in place of Intermediate 16 and 2-chloro-N-methylacetamide in place of Intermediate 1. MS (ESI): mass calcd. for C₁₆H₁₅FN₄O, 298.1; m/z found, 299.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.85 (d, J=1.9 Hz, 1H), 8.41-8.37 (m, 1H), 8.34-8.30 (m, 1H), 8.11-8.04 (m, 1H), 7.77 (dd, J=7.4, 2.4 Hz, 1H), 7.70-7.64 (m, 1H), 7.33-7.27 (m, 1H), 5.17 (s, 2H), 2.62 (d, J=4.6 Hz, 3H), 2.34 (d, J=1.8 Hz, 3H).

Example 223: 2-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10. MS (ESI): mass calcd. for C₁₇H₁₆F₂N₄O, 330.1; m/z found, 331.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=1.8 Hz, 1H), 8.39-8.35 (m, 1H), 7.78-7.74 (m, 1H), 7.69-7.65 (m, 1H), 7.35-7.30 (m, 1H), 5.40 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H), 2.35 (d, J=1.8 Hz, 3H).

Example 224: 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 4-chloro-3-methylphenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₇ClN₄O, 328.1; m/z found, 329.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.86 (d, J=1.9 Hz, 1H), 8.39-8.34 (m, 1H), 8.31 (s, 1H), 7.86-7.79 (m, 1H), 7.66 (dd, J=8.3, 2.3 Hz, 1H), 7.57 (d, J=8.3 Hz, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H), 2.44 (s, 3H).

Example 225: 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 3-chloro-4-fluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₄ClFN₄O, 332.1; m/z found, 333.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.88 (d, J=2.0 Hz, 1H), 8.45-8.39 (m, 1H), 8.32 (d, J=0.9 Hz, 1H), 8.06 (dd, J=7.1, 2.4 Hz, 1H), 7.88-7.81 (m, 1H), 7.60 (t, J=8.9 Hz, 1H), 5.51 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 226: 2-[6-(3,4-Dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 3,4-dichlorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₄C₁₂N₄O, 348.1; m/z found, 349.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.91 (d, J=1.9 Hz, 1H), 8.50-8.42 (m, 1H), 8.33 (s, 1H), 8.11 (d, J=1.9 Hz, 1H), 7.85 (dd, J=8.4, 2.0 Hz, 1H), 7.80 (d, J=8.4 Hz, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 227: 2-[6-(3,5-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 3,5-difluorophenylboronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄O, 334.1; m/z found, 335.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.98 (d, J=1.9 Hz, 1H), 8.57-8.51 (m, 1H), 7.70-7.60 (m, 2H), 7.43-7.31 (m, 1H), 5.40 (s, 2H), 3.11 (s, 3H), 2.84 (s, 3H).

Example 228: 2-[6-(3,4-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 3,4-difluorophenylboronic acid in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄O, 334.1; m/z found, 335.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.93 (d, J=1.9 Hz, 1H), 8.48-8.43 (m, 1H), 8.00-7.94 (m, 1H), 7.73-7.68 (m, 1H), 7.64 (dt, J=10.5, 8.5 Hz, 1H), 5.40 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H).

Example 229: 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridine (Intermediate 20) in place of Intermediate 16. MS (ESI): mass calcd. for C₁₈H₁₈F₂N₄O, 344.1; m/z found, 345.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.90 (d, J=1.9 Hz, 1H), 8.43-8.37 (m, 1H), 8.37-8.31 (m, 1H), 7.97-7.88 (m, 2H), 7.72-7.61 (m, 2H), 5.54 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H), 2.06 (t, J=18.9 Hz, 3H).

Example 230: 2-[6-[3-(1,1-Difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 2-(3-(1,1-difluoroethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₈H₁₇F₃N₄O, 362.1; m/z found, 363.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.48-8.44 (m, 1H), 7.99-7.91 (m, 2H), 7.72-7.64 (m, 2H), 5.43 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H), 2.06 (t, J=18.9 Hz, 3H).

Example 231: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16. MS (ESI): mass calcd. for C₁₇H₁₅F₃N₄O₂, 364.1; m/z found, 365.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.92-8.83 (m, 1H), 8.43-8.35 (m, 1H), 8.35-8.30 (m, 1H), 7.87-7.79 (m, 1H), 7.79-7.70 (m, 1H), 7.63-7.55 (m, 1H), 7.38 (t, J=73.3 Hz, 1H), 5.52 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H).

Example 232: 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(6-bromo-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)-N,N-dimethylacetamide (Intermediate 11) in place of Intermediate 10 and 2-(3-(difluoromethoxy)-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylphenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₄N₄O₂, 382.1; m/z found, 383.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.92 (d, J=1.8 Hz, 1H), 8.44-8.41 (m, 1H), 7.86-7.82 (m, 1H), 7.79-7.73 (m, 1H), 7.61 (dd, J=10.5, 8.6 Hz, 1H), 7.38 (t, J=73.2 Hz, 1H), 5.41 (s, 2H), 3.10 (s, 3H), 2.84 (s, 3H).

Example 233: 2-[6-[2-Fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was prepared in a manner analogous to Example 11 using 2-fluoro-3-(trifluoromethyl)phenylboronic acid in place of 3-(trifluoromethyl)phenylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₄F₄N₄O, 366.1; m/z found, 367.1 [M+H]⁺. ¹H NMR (500 MHz, CDCl₃) δ 8.73 (t, J=1.6 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.99 (q, J=1.6 Hz, 1H), 7.76-7.64 (m, 2H), 7.38 (t, J=7.8 Hz, 1H), 5.30 (s, 2H), 3.18 (s, 3H), 2.98 (s, 3H).

Example 234: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-methoxyethyl)-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using 2-methoxy-N-methylethan-1-amine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₉F₃N₄O₂, 392.1; m/z found, 393.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.82-8.71 (m, 1H), 8.36-8.25 (m, 1H), 7.92-7.82 (m, 2H), 7.80-7.67 (m, 1H), 7.29 (d, J=9.4 Hz, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.51-5.17 (m, 2H), 3.73-3.50 (m, 4H), 3.46-3.27 (m, 3H), 3.26-2.92 (m, 3H).

Example 235: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-hydroxyethyl)-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using 2-(methylamino)ethan-1-ol in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₇F₃N₄O₂, 378.1; m/z found, 379.0 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.86-8.70 (m, 1H), 8.37-8.21 (m, 1H), 7.98-7.80 (m, 2H), 7.78-7.68 (m, 1H), 7.34-7.24 (m, 1H), 7.16-6.76 (m, 1H), 5.48-5.29 (m, 2H), 3.95-3.75 (m, 2H), 3.74-3.53 (m, 2H), 3.28-2.95 (m, 3H), 2.42-2.20 (m, 1H).

Example 236: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-N-(2,2,2-trifluoroethyl)acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methyl-2,2,2-trifluoroethylamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₄F₆N₄O, 416.1; m/z found, 417.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.32 (d, J=1.0 Hz, 1H), 7.93-7.80 (m, 2H), 7.73 (s, 1H), 7.30 (d, J=9.2 Hz, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.34 (d, J=20.7 Hz, 2H), 4.28-3.97 (m, 2H), 3.38-2.90 (m, 3H).

Example 237: N-(Cyanomethyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using 2-(methylamino)acetonitrile in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₈H₁₄F₃N₅O, 373.1; m/z found, 374.1 [M+H]⁺. ¹H NMR (400 MHz, Methanol-d₄) δ 8.78 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 8.16 (dd, J=1.9, 1.0 Hz, 1H), 7.96-7.89 (m, 1H), 7.85 (dddd, J=7.4, 4.9, 2.5, 1.3 Hz, 1H), 7.45-7.29 (m, 1H), 7.01 (t, J=54.8 Hz, 1H), 5.52 (s, 2H), 4.43 (s, 2H), 3.35 (s, 3H).

Example 238: N-Allyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methylallylamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80-8.77 (m, 1H), 8.32-8.26 (m, 1H), 7.93-7.89 (m, 1H), 7.88-7.83 (m, 1H), 7.78-7.72 (m, 1H), 7.32-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.91-5.66 (m, 1H), 5.38-5.08 (m, 4H), 4.19-3.90 (m, 2H), 3.21-2.88 (m, 3H).

Example 239: N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 7 using 3,4,5-trifluorophenylboronic acid in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₆H₁₃F₃N₄O, 334.1; m/z found, 335.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.92 (d, J=2.0 Hz, 1H), 8.49-8.45 (m, 1H), 8.35-8.32 (m, 1H), 7.92-7.82 (m, 2H), 5.50 (s, 2H), 3.14 (s, 3H), 2.86 (s, 3H).

Example 240: 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(3,4-difluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₆F₂N₄O, 330.1; m/z found, 331.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.87 (d, J=1.9 Hz, 1H), 8.38 (dd, J=2.0, 1.0 Hz, 1H), 8.31 (d, J=1.0 Hz, 1H), 7.78-7.70 (m, 1H), 7.64-7.58 (m, 1H), 5.50 (s, 2H), 3.13 (s, 3H), 2.85 (s, 3H), 2.39 (d, J=2.1 Hz, 3H).

Example 241: 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide

The title compound was made in a manner analogous to Example 7 using 2-(2,4-difluoro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in place of 4-fluoro-3-methylboronic acid. MS (ESI): mass calcd. for C₁₇H₁₆F₂N₄O, 330.1; m/z found, 331.2 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.69-8.60 (m, 1H), 8.34 (s, 1H), 8.27-8.18 (m, 1H), 7.58-7.43 (m, 1H), 7.31-7.18 (m, 1H), 5.51 (s, 2H), 3.11 (s, 3H), 2.84 (s, 3H), 2.32-2.18 (m, 3H).

Example 242: N-Cyclopropyl-N-methyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was prepared in a manner analogous to Example 16, using N-methylcyclopropanamine hydrochloride in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d6) □ 8.95-8.90 (m, 1H), 8.54-8.45 (m, 1H), 8.37-8.32 (m, 1H), 8.17-8.10 (m, 2H), 7.86-7.76 (m, 2H), 5.62 (s, 1.84H), 5.48 (s, 0.14H), 3.04 (s, 0.23H), 3.02-2.95 (m, 1H), 2.83 (s, 2.81), 1.02-0.90 (m, 3.74H), 0.70-0.55 (m, 0.32H).

Example 243: N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 6, Method A, using 2-chloro-N-cyclopropylacetamide in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O, 360.1; m/z found, 361.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d6) δ 8.89 (d, J=2.0 Hz, 1H), 8.53-8.46 (m, 1H), 8.38 (d, J=4.2 Hz, 1H), 8.34 (s, 1H), 8.11-8.01 (m, 2H), 7.63-7.52 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.14 (s, 2H), 2.72-2.56 (m, 1H), 0.69-0.58 (m, 2H), 0.50-0.39 (m, 2H).

Example 244: N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methylcycloproanamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.77 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.88-7.84 (m, 2H), 7.80-7.69 (m, 1H), 7.32-7.26 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.48 (s, 2H), 2.97 (s, 3H), 2.89 (tt, J=7.1, 3.9 Hz, 1H), 1.13-1.03 (m, 2H), 1.00-0.92 (m, 2H).

Example 245: N-Cyclopropyl-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was prepare in a manner analogous to Example 15, using 2-(3-methyl-6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 51) in place of Intermediate 39 and cyclopropanamine in place of 1-methylazetidin-3-amine. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.47 (d, J=1.9 Hz, 1H), 8.33 (d, J=4.2 Hz, 1H), 8.16-8.11 (m, 2H), 7.85-7.75 (m, 2H), 5.06 (s, 2H), 2.69-2.61 (m, 1H), 2.55 (s, 3H), 0.66-0.59 (m, 2H), 0.47-0.42 (m, 2H).

Example 246: N-Cyclopropyl-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 6, Method A, using 6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridine (Intermediate 17) in place of Intermediate 16 and 2-chloro-N-cyclopropylacetamide in place of 2-chloro-N,N-dimethylacetamide. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.50-8.40 (m, 1H), 8.39 (d, J=4.1 Hz, 1H), 8.34 (s, 1H), 7.87-7.80 (m, 1H), 7.81-7.73 (m, 1H), 7.60 (dd, J=10.6, 8.4 Hz, 1H), 7.39 (t, J=73.2 Hz, 1H), 5.13 (s, 2H), 2.70-2.59 (m, 1H), 0.69-0.58 (m, 2H), 0.50-0.38 (m, 2H).

Example 247: N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-N-cyclobutylacetamide (Intermediate 7) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.88 (d, J=1.9 Hz, 1H), 8.56 (d, J=7.7 Hz, 1H), 8.52-8.46 (m, 1H), 8.33 (s, 1H), 8.11-8.00 (m, 2H), 7.63-7.51 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.16 (s, 2H), 4.28-4.10 (m, 1H), 2.23-2.07 (m, 2H), 2.03-1.83 (m, 2H), 1.74-1.51 (m, 2H).

Example 248: N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methylcyclobutylamine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₀H₁₉F₃N₄O, 388.2; m/z found, 389.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.77 (d, J=1.9 Hz, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.90-7.81 (m, 2H), 7.78-7.72 (m, 1H), 7.31-7.26 (m, 1H), 6.97 (t, J=54.9 Hz, 1H), 5.33-5.21 (m, 2H), 4.93-4.46 (m, 1H), 3.14-2.92 (m, 3H), 2.40-2.06 (m, 4H), 1.72 (dq, J=28.5, 9.8 Hz, 2H).

Example 249: N-Cyclobutyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was prepared in a manner analogous to Example 16, using cyclobutanamine in place of 3-fluoroazetidine hydrochloride and DCM in place of DMF. MS (ESI): mass calcd. for C₁₉H₁₇F₃N₄O, 374.1; m/z found, 375.2 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 8.94 (d, J=2.0 Hz, 1H), 8.58-8.53 (m, 2H), 8.36-8.33 (m, 1H), 8.18-8.13 (m, 2H), 7.84-7.76 (m, 2H), 5.17 (s, 2H), 4.24-4.14 (m, 1H), 2.20-2.12 (m, 2H), 1.98-1.88 (m, 2H), 1.70-1.56 (m, 2H).

Example 250: N-(3,3-Difluorocyclobutyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was prepared in a manner analogous to Example 13, using 3,3-difluorocyclobutan-1-amine hydrochloride in place of morpholine. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.89 (d, J=1.85 Hz, 1H), 8.42 (d, J=0.92 Hz, 1H), 7.93 (dd, J=1.85, 0.92 Hz, 1H), 7.89 (s, 1H), 7.84 (d, J=7.63 Hz, 1H), 7.76-7.71 (m, 1H), 7.70-7.64 (m, 1H), 6.45 (d, J=6.01 Hz, 1H), 5.09 (s, 2H), 4.31-4.18 (m, 1H), 3.05-2.89 (m, 2H), 2.52-2.34 (m, 2H).

Example 251: N-(3,3-Difluorocyclobutyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was made in a manner analogous to Example 5, Method A, using 2-chloro-N-(3,3-difluorocyclobutyl)acetamide (Intermediate 2) in place of Intermediate 1. MS (ESI): mass calcd. for C₁₉H₁₅F₅N₄O, 410.1; m/z found, 411.1 [M+H]⁺. ¹H NMR (300 MHz, DMSO-d₆) δ 8.89 (d, J=1.9 Hz, 1H), 8.76 (d, J=6.7 Hz, 1H), 8.54-8.47 (m, 1H), 8.36 (s, 1H), 8.15-7.99 (m, 2H), 7.64-7.51 (m, 1H), 7.30 (t, J=54.1 Hz, 1H), 5.21 (s, 2H), 4.18-3.97 (m, 1H), 3.01-2.81 (m, 2H), 2.69-2.39 (m, 2H).

Example 252: N-(3-Bicyclo[1.1.1]pentanyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide

The title compound was prepared in a manner analogous to Example 1 using N-methyl bicyclo[1.1.1]pentan-1-amine in place of 3-(trifluoromethyl)azetidine-3-ol. MS (ESI): mass calcd. for C₂₁H₁₉F₃N₄O, 400.2; m/z found, 401.3 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.77 (d, J=1.9 Hz, 1H), 8.34-8.24 (m, 1H), 7.89-7.80 (m, 2H), 7.79-7.71 (m, 1H), 7.31-7.27 (m, 1H), 6.98 (t, J=54.9 Hz, 1H), 5.37-5.18 (m, 2H), 3.12-2.87 (m, 3H), 2.66-2.42 (m, 1H), 2.36-2.09 (m, 6H).

Example 253: N-(Oxetan-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide

The title compound was prepared in a manner analogous to Example 15, using 3-oxetanamine in place of 1-methylazetidin-3-amine. MS (ESI): mass calcd. for C₁₈H₁₅F₃N₄O₂, 376.1; m/z found, 377.1 [M+H]⁺. ¹H NMR (500 MHz, DMSO-d₆) δ 9.06 (d, J=6.8 Hz, 1H), 8.95 (d, J=1.9 Hz, 1H), 8.58-8.55 (m, 1H), 8.37-8.35 (m, 1H), 8.18-8.13 (m, 2H), 7.84-7.76 (m, 2H), 5.25 (s, 2H), 4.86-4.78 (m, 1H), 4.74-4.69 (m, 2H), 4.48-4.44 (m, 2H).

Example 254: 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-3-yl)azetidin-1-yl)ethan-1-one

To a solution of 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 27, 40 mg, 0.125 mmol) in DCM (1 mL) were added DIPEA (170 μL, 0.62 mmol) and 3-(azetidin-3-yl)pyridine dihydrochloride (52 mg, 0.25 mmol), followed by PyBOP (84 mg, 0.16 mmol). The reaction mixture was stirred for two hours and purified on silica gel (0-10% MeOH/DCM) followed by reverse phase HPLC (METHOD D) to afford the title compound (24.2 mg, 44%). MS (ESI): mass calcd. for C₂₃H₁₈F₃N₅O, 437.1; m/z found, 438.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81 (d, J=1.9 Hz, 1H), 8.65-8.50 (m, 2H), 8.31 (d, J=1.0 Hz, 1H), 8.00 (dd, J=2.0, 1.0 Hz, 1H), 7.95-7.81 (m, 1H), 7.82-7.73 (m, 1H), 7.72-7.58 (m, 1H), 7.40-7.28 (m, 2H), 6.98 (t, J=54.9 Hz, 1H), 5.14 (s, 2H), 4.62-4.45 (m, 2H), 4.19-4.09 (m, 2H), 3.96-3.82 (m, 1H).

Example 255: 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-2-yl)azetidin-1-yl)ethan-1-one

The title compound was prepared in a manner analogous to Example 254, using 2-(azetidin-3-yl)pyridine dihydrochloride in place of 3-(azetidin-3-yl)pyridine dihydrochloride. MS (ESI): mass calcd. for C₂₃H₁₁F₃N₅O, 437.1; m/z found, 438.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.80 (d, J=1.9 Hz, 1H), 8.66-8.54 (m, 1H), 8.30 (d, J=1.0 Hz, 1H), 7.99 (dd, J=1.9, 1.0 Hz, 1H), 7.92-7.85 (m, 1H), 7.85-7.72 (m, 1H), 7.70-7.57 (m, 1H), 7.33-7.27 (m, 1H), 7.23-7.18 (m, 1H), 7.16-7.13 (m, 1H), 6.98 (t, J=54.8 Hz, 1H), 5.24-5.04 (m, 2H), 4.50-4.39 (m, 3H), 4.34-4.23 (m, 1H), 4.02-3.89 (m, 1H).

Example 256: Methyl (1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)carbamate

The title compound was prepared in a manner analogous to Example 254, using 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 28) in place of 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 27) and methyl azetidin-3-ylcarbamate in place of 3-(azetidin-3-yl)pyridine dihydrochloride. MS (ESI): mass calcd. for C₂₀H₁₇F₄N₅O₃, 451.1; m/z found, 452.1 [M+H]⁺. ¹H NMR (400 MHz, DMSO-d₆) δ 8.94 (d, J=1.9 Hz, 1H), 8.48 (t, J=2.0 Hz, 1H), 8.07 (dd, J=5.1, 2.4 Hz, 2H), 7.90 (d, J=6.9 Hz, 1H), 7.68-7.55 (m, 1H), 7.32 (t, J=54.1 Hz, 1H), 5.37-5.07 (m, 2H), 4.49-4.26 (m, 2H), 4.20-3.98 (m, 2H), 3.79 (dd, J=9.8, 5.4 Hz, 1H), 3.56 (s, 3H).

Example 257: (S)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide

To a solution of 2-(6-(3-(difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetic acid (Intermediate 28, 25 mg, 0.074 mmol) in DMF (1 mL) were added DIPEA (40 μL, 0.22 mmol) and (S)-N-(pyrrolidin-3-yl)acetamide (19 mg, 0.15 mmol), followed by COMU ((1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate) (38 mg, 0.088 mmol). The reaction mixture was stirred for 90 minutes and purified by reverse phase HPLC (METHOD D) to afford the title compound (4.9 mg, 0.011 mmol, 15%). MS (ESI): mass calcd. for C₂₁H₁₉F₄N₅O₂, 449.1; m/z found, 472.2 [M+Na]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.83-8.75 (m, 1H), 7.91-7.80 (m, 2H), 7.79-7.69 (m, 1H), 7.34-7.27 (m, 1H), 6.97 (t, J=54.8 Hz, 1H), 6.16-5.91 (m, 1H), 5.33-4.94 (m, 2H), 4.67-4.40 (m, 1H), 4.20-3.40 (m, 4H), 2.50-1.20 (m, 5H).

Example 258: (R)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide

The title compound was prepared in a manner analogous to Example 257, using (R)-N-(pyrrolidin-3-yl)acetamide in place of (S)-N-(pyrrolidin-3-yl)acetamide. MS (ESI): mass calcd. for C₂₁H₁₉F₄N₅O₂, 449.1; m/z found, 450.1 [M+H]⁺. ¹H NMR (400 MHz, CDCl₃) δ 8.81-8.72 (m, 1H), 7.89-7.80 (m, 2H), 7.77-7.69 (m, 1H), 7.34-7.27 (m, 1H), 7.14-6.74 (m, 1H), 6.43-6.08 (m, 1H), 5.38-4.93 (m, 2H), 4.65-4.37 (m, 1H), 3.94-3.41 (m, 4H), 2.32-1.61 (m, 5H).

Example 259: 1-(3-(Fluoro-18F)azetidin-1-yl)-2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one

[¹⁸F]fluoride in a shipping vial (obtained from the cyclotron facility) was transferred onto and trapped on an ion exchange cartridge, then eluted into a reaction vessel of a Synthra RNPlus® module with a solution of potassium bicarbonate (1.09 mg, 0.011 mmol) and Kryptofix 222 (7.2 mg, 0.019 mmol) in 0.8 mL of acetonitrile/water (6/2, v/v). The solvent was evaporated under a stream of nitrogen at 85° C. and under vacuum. Anhydrous CH₃CN (0.5 mL) was added to the reaction vessel and the above process was repeated with the temperature increased to 110° C. for 3.5 min. The reaction vial was then cooled to 70° C. before a solution of 1-(2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl 4-methylbenzenesulfonate (Intermediate 70, 3.0 mg, 0.0053 mmol) in anhydrous MeCN (0.7 mL) was added to the reaction vessel. The reaction mixture was heated at 90° C. for 5 min. The reactor was cooled to 70° C. and 0.5 mL HCl (1.0 M) was added to the solution. The reaction was heated at 90° C. for 2 min before the reactor was cooled to 40° C. and 1.0 mL Na₂HPO₄ (0.5M) was added to the mixture. The solution was further diluted with water (2.8 mL) and the mixture was transferred into the HPLC injector loop for purification. Purification was performed by HPLC using a semi-preparative Eclipse XDB-C18 column (5 μm, 9.4 mm×250 mm) eluted with a mixture of 10 mM NH₄OAc and MeCN (62:38 v/v) at a flow rate of 4 mL/min with UV detection at 254 nm. The purified radiotracer solution was diluted with 30 mL of water and passed through a SepPak Light C-18 cartridge. The C-18 cartridge was further washed with 10 mL of water before 0.5 mL EtOH was used to elute the tracer. The tracer solution was further diluted with 4.5 mL of saline. The final formulation contains an ethanol concentration of 10%, suitable for intravenous injection (IV).

Biological Assays Effects of Test Articles on Cloned Human NR1/GluN2B Ion Channels Expressed in Mammalian Cells

NMDA receptors are ion channels that are highly permeable to Ca²⁺ ions, rendering it possible to monitor NMDA receptor function using cell-based calcium flux assay. In this assay, co-agonists glutamate and glycine are added to cells heterologously expressing human GluN1/GluN2B NMDA receptors to initiate cellular Ca²⁺ influx. The time course of the changes in intracellular calcium is measured using a fluorescent dye and a FLIPR (Fluorometric Imaging Plate Reader) device. Twenty four hours before measurements, the expression of the NMDA receptors in the stable cell line is induced with Tet-On inducible system in the presence of a non-selective NMDA receptor blocker. On the day of the experiment, cell culture media is carefully washed and the cells are loaded with Calcium 5 Dye Kit (Molecular Devices) in dye loading buffer containing 137 mM NaCl, 4 mM KCl, 2 mM CaCl₂), 0.5 mM MgCl₂ (standard assay) or 1.5 mM MgCl₂ (HTS assay), 10 mM HEPES and 5 mM D-glucose; pH 7.4. After 1 h incubation at the room temperature, the dye is washed away with the assay buffer (137 mM NaCl (standard assay) or 150 mM (HTS assay), 4 mM KCl (standard assay) or 3 mM (HTS assay), 2 mM CaCl₂), 0.01 mM EDTA, 10 mM HEPES and 5 mM D-glucose; pH 7.4) In the FLIPR TETRA reader, various concentrations of the test compounds are added to the cells for 5 min while fluorescence is monitored to detect potential agonist activity. Next, co-agonists, glutamate and glycine are added for another 5 minutes. The concentration of glutamate corresponding to ˜EC₄₀ (standard assay) or EC₄₀ (HTS assay) is used to maximize the assay's signal window and ability to detect NMDA receptor antagonists and negative allosteric modulators. A saturating concentration (10 μM) of glycine is also present in the assay. A non-selective NMDA receptor antagonist, (+)MK-801 is used as a positive control for antagonist activity. The fluorescent signal in the presence of test compounds is quantified and normalized to the signal defined by the appropriate control wells.

TABLE 3 GluN2B IC₅₀ (μM) Example # Compound Name standard assay  1 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.444 yl]-1-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]ethanone;  2 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.070 yl]-1-(3-methyleneazetidin-1-yl)ethanone;  3 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.635 yl]-1-[3-(methylamino)azetidin-1-yl]ethanone;  4 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.110 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-N-methyl-acetamide;  5 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.016 yl]-1-(3-fluoroazetidin-1-yl)ethanone;  6 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.018 yl]-N,N-dimethyl-acetamide;  7 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.025 dimethyl-acetamide;  8 N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo 0.395 [4,3-b]pyridin-1-yl]acetamide;  9 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin- 0.022 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  10 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin- 0.024 1-yl]-N,N-dimethyl-acetamide;  11 N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3- 0.125 [4,3-b]pyridin-1-yl]acetamide;  12 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.068 yl]-1-morpholino-ethanone;  13 1-Morpholino-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 0.219 [4,3-b]pyridin-1-yl]ethanone;  14 N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 0.437 [4,3-b]pyridin-1-yl]acetamide;  15 N-(1-Methylazetidin-3-yl)-2-[6-[3- 8.110 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide;  16 1-(3-Fluoroazetidin-1-yl)-2-[6-[3- 0.042 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  17 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2,4-difluorophenyl)pyrazolo 0.356 [4,3-b]pyridin-1-yl]ethanone;  18 1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)-3-fluoro-pyrazolo 0.012 [4,3-b]pyridin-1-yl]ethanone;  19 1-(Azetidin-1-yl)-2-[6-[5-(difluoromethyl)-2-thienyl]-3-fluoro- 0.013 pyrazolo[4,3-b]pyridin-1-yl]ethanone;  20 1-(Azetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2- 0.021 thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  21 1-(Azetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1- 0.299 yl]ethanone;  22 1-(Azetidin-1-yl)-2-[6-(3-chlorophenyl)pyrazolo[4,3-b]pyridin-1- 0.027 yl]ethanone;  23 1-(Azetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo 0.020 [4,3-b]pyridin-1-yl]ethanone;  24 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo 0.048 [4,3-b]pyridin-1-yl]ethanone;  25 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]pyrazolo 0.044 [4,3-b]pyridin-1-yl]ethanone;  26 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]-3-fluoro- 0.066 pyrazolo[4,3-b]pyridin-1-yl]ethanone;  27 1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 0.037 [4,3-b]pyridin-1-yl]ethanone;  28 1-(Azetidin-1-yl)-2-[3-methyl-6-[3- 0.187 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  29 1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl)pyrazolo[4,3-b]pyridin- 0.028 1-yl]ethanone;  30 1-(Azetidin-1-yl)-2-[6-(2,3-dichlorophenyl)pyrazolo[4,3-b]pyridin- 0.040 1-yl]ethanone;  31 1-(Azetidin-1-yl)-2-[6-(3-chloro-2-fluoro-phenyl)pyrazolo 0.070 [4,3-b]pyridin-1-yl]ethanone;  32 1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin- 0.044 1-yl]ethanone;  33 1-(Azetidin-1-yl)-2-[6-[2-fluoro-3- 0.045 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  34 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)-4-fluoro- 0.066 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  35 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.017 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  36 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3- 0.020 fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  37 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3- 0.064 methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  38 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)pyrazolo 0.024 [4,3-b]pyridin-1-yl]ethanone;  39 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)-3-methyl- 0.088 pyrazolo[4,3-b]pyridin-1-yl]ethanone;  40 1-(Azetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo 0.038 [4,3-b]pyridin-1-yl]ethanone;  41 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro- 0.028 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  42 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]-3- 0.040 fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  43 1-(Azetidin-1-yl)-2-[6-[4-chloro-3- 0.024 (difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  44 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]-3- 0.040 fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone;  45 1-(Azetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo 0.118 [4,3-b]pyridin-1-yl]ethanone;  46 2-[6-(3-Acetyl-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1- 0.161 (azetidin-1-yl)ethanone;  47 1-(Azetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3- 0.047 [4,3-b]pyridin-1-yl]ethanone;  48 1-(Azetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo 0.286 [4,3-b]pyridin-1-yl]ethanone;  49 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.025 fluoroazetidin-1-yl)ethanone;  50 2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1- 0.018 (3-fluoroazetidin-1-yl)ethanone;  51 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-1- 0.032 (3-fluoroazetidin-1-yl)ethanone;  52 2-[6-[5-(Difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo 0.022 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  53 1-(3-Fluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-2- 0.012 thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  54 1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2- 0.040 thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  55 1-(3-Fluoroazetidin-1-yl)-2-[6-(3-fluorophenyl)pyrazolo 0.106 [4,3-b]pyridin-1-yl]ethanone;  56 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo 0.053 [4,3-b]pyridin-1-yl]ethanone;  57 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.019 fluoroazetidin-1-yl)ethanone;  58 1-(3-Fluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1- 0.045 yl]ethanone;  59 1-(3-Fluoroazetidin-1-yl)-2-[6-[3- 0.040 (fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  60 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.030 fluoroazetidin-1-yl)ethanone;  61 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1- 0.029 (3-fluoroazetidin-1-yl)ethanone;  62 2-[6-[3-(Difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.097 fluoroazetidin-1-yl)ethanone;  63 2-[6-(2,3-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.525 fluoroazetidin-1-yl)ethanone;  64 2-[6-(2,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.189 fluoroazetidin-1-yl)ethanone;  65 2-[6-(3,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.111 fluoroazetidin-1-yl)ethanone;  66 2-[6-(3,5-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.065 fluoroazetidin-1-yl)ethanone;  67 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.183 fluoroazetidin-1-yl)ethanone;  68 2-[6-(3-Chloro-4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.017 fluoroazetidin-1-yl)ethanone;  69 1-(3-Chloroazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.032 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  70 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.027 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  71 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo 0.030 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  72 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.044 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  73 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.092 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  74 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin- 0.047 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  75 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo 0.124 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  76 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- 0.016 yl]-1-(3-fluoroazetidin-1-yl)ethanone;  77 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3- 0.041 fluoroazetidin-1-yl)ethanone;  78 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy- 0.129 phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone;  79 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.016 1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  80 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.032 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  81 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo 0.037 [4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;  82 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1- 0.023 (3-fluoroazetidin-1-yl)ethanone;  83 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1- 0.017 (3-fluoroazetidin-1-yl)ethanone;  84 1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo 0.068 [4,3-b]pyridin-1-yl]ethanone;  85 1-(3-Fluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4- 0.291 pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  86 1-(3-Methylazetidin-1-yl)-2-[6-[3- 0.038 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  87 (Racemic) 1-(2-Methylazetidin-1-yl)-2-[6-[3- 0.216 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  88 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.073 yl]-1-(3-methylazetidin-1-yl)ethanone;  89 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.038 [4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone;  90 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.098 [4,3-b]pyridin-1-yl]-1-(2-methylazetidin-1-yl)ethanone;  91 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.063 1-yl]-1-(3-methylazetidin-1-yl)ethanone;  92 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.092 [4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone;  93 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo 0.173 [4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone;  94 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.068 yl]-1-(3-ethynylazetidin-1-yl)ethanone;  95 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.096 yl]-1-(3-vinylazetidin-1-yl)ethanone;  96 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.107 yl]-1-[3-[(Z)-prop-1-enyl]azetidin-1-yl]ethanone;  97 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.067 yl]-1-[3-(fluoromethyl)azetidin-1-yl]ethanone;  98 1-[3-(Difluoromethyl)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4- 0.114 fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone;  99 1-[3-(Trifluoromethyl)azetidin-1-yl]-2-[6-[3- 0.660 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 100 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.537 yl]-1-[3-(trifluoromethyl)azetidin-1-yl]ethanone; 101 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.130 yl]-1-[3-[(Z)-2-fluorovinyl]azetidin-1-yl]ethanone; 102 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.147 yl]-1-[3-(2,2-difluorovinyl)azetidin-1-yl]ethanone; 103 1-(3-Methoxyazetidin-1-yl)-2-[6-[3- 0.402 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 104 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.078 yl]-1-(3-methoxyazetidin-1-yl)ethanone; 105 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.215 yl]-1-(3-ethoxyazetidin-1-yl)ethanone; 106 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.152 yl]-1-[3-(methoxymethyl)azetidin-1-yl]ethanone; 107 1-[3-(Methoxymethyl)azetidin-1-yl]-2-[6-[3- 0.126 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 108 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.623 [4,3-b]pyridin-1-yl]-1-[3-(1-hydroxyethyl)azetidin-1-yl]ethanone; 109 1-[3-(Difluoromethoxy)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4- 0.115 fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 110 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.491 yl]-1-[3-(trifluoromethoxy)azetidin-1-yl]ethanone; 111 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.042 yl]-1-(3-hydroxyazetidin-1-yl)ethanone; 112 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.033 [4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; 113 1-(3-Hydroxyazetidin-1-yl)-2-[6-[3- 0.133 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 114 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.083 yl]-1-[3-(hydroxymethyl)azetidin-1-yl]ethanone; 115 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-methyl-2-thienyl)pyrazolo 0.053 [4,3-b]pyridin-1-yl]ethanone; 116 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo 0.194 [4,3-b]pyridin-1-yl]ethanone; 117 2-[6-[3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3- 0.039 difluoroazetidin-1-yl)ethanone; 118 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin- 0.052 1-yl]ethanone; 119 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3- 0.046 (difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 120 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3- 0.092 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 121 3-[1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]pyrazolo 2.480 [4,3-b]pyridin-6-yl]benzonitrile; 122 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[6-(trifluoromethyl)-2- 0.405 pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 123 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4- 0.293 pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 124 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-3- 0.459 pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 125 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo 0.092 [4,3-b]pyridin-1-yl]ethanone; 126 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,5-difluorophenyl)pyrazolo 0.070 [4,3-b]pyridin-1-yl]ethanone; 127 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3- 0.020 difluoroazetidin-1-yl)ethanone; 128 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3- 0.048 difluoroazetidin-1-yl)ethanone; 129 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl- 0.068 phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 130 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methyl- 0.310 phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 131 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2-fluoro-3-methyl- 0.031 phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 132 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-3- 0.037 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 133 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[4-fluoro-3- 0.065 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 134 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-5- 0.262 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 135 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-methyl-3- 2.099 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 136 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy- 0.160 phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 137 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4,5- 0.039 trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 138 1-(3,3-Dimethylazetidin-1-yl)-2-[6-[3- 0.263 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 139 1-(3-Fluoro-3-methyl-azetidin-1-yl)-2-[6-[3- 0.059 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 140 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.119 yl]-1-(3,3-dimethylazetidin-1-yl)ethanone; 141 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.069 yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone; 142 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.237 yl]-1-(3-ethyl-3-fluoro-azetidin-1-yl)ethanone; 143 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.082 yl]-1-[3-fluoro-3-(fluoromethyl)azetidin-1-yl]ethanone; 144 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.469 yl]-1-(3-methoxy-3-methyl-azetidin-1-yl)ethanone; 145 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.433 yl]-1-(3-ethyl-3-hydroxy-azetidin-1-yl)ethanone; 146 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.073 yl]-1-(3-hydroxy-3-methyl-azetidin-1-yl)ethanone; 147 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.121 yl]-1-[3-fluoro-3-(hydroxymethyl)azetidin-1-yl]ethanone; 148 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.155 yl]-1-[3-fluoro-3-(methoxymethyl)azetidin-1-yl]ethanone; 149 [6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.456 yl]-1-(3-hydroxy-2-methyl-azetidin-1-yl)ethanone; 150 1-[2-[6-[3-(Trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- 0.330 yl]acetyl]azetidine-3-carbonitrile; 151 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.063 [4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile; 152 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.075 [4,3-b]pyridin-1-yl]acetyl]-3-methyl-azetidine-3-carbonitrile; 153 1-(3-Acetylazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.336 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 154 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.064 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]acetamide; 155 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.727 [4,3-b]pyridin-1-yl]acetyl]-N,N-dimethyl-azetidine-3-carboxamide; 156 MethylN-[1-[2-[6-[3-(difluoromethyl)-4-fluoro- 0.038 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]carbamate; 157 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.122 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-2,2,2-trifluoro-acetamide; 158 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.066 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]cyclopropanecarboxamide; 159 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.157 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]methanesulfonamide; 160 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 3.250 yl]-1-(3-methylsulfonylazetidin-1-yl)ethanone; 161 1-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.246 [4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]pyrrolidin-2-one; 162 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.041 yl]-1-[3-(1H-imidazol-2-yl)azetidin-1-yl]ethanone; 163 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.067 yl]-1-[3-(4-pyridyl)azetidin-1-yl]ethanone; 164 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.111 yl]-1-(3-pyrimidin-4-ylazetidin-1-yl)ethanone; 165 1-(5-Azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.133 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 166 1-(2,2-Difluoro-5-azaspiro[2.3]hexan-5-yl)-2-[6-[3- 0.197 (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 167 1-(6-Azaspiro[3.3]heptan-6-yl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.397 phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 168 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.141 yl]-1-(3-oxa-6-azaspiro[3.3]heptan-6-yl)ethanone; 169 1-(6-Oxa-2-azaspiro[3.3]heptan-2-yl)-2-[6-[3- 0.400 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 170 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1- 0.304 yl-ethanone; 171 1-Pyrrolidin-1-yl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 0.101 [4,3-b]pyridin-1-yl]ethanone; 172 2-[6-(3-Cyclopropylphenyl)pyrazolo[4,3-b]pyridin-1-yl]-1- 0.375 pyrrolidin-1-yl-ethanone; 173 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.084 1-yl]-1-pyrrolidin-1-yl-ethanone; 174 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.022 yl]-1-pyrrolidin-1-yl-ethanone; 175 2-[6-(3,5-Difluoro-4-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1- 1.322 pyrrolidin-1-yl-ethanone; 176 1-[(3R)-3-Fluoropyrrolidin-1-yl]-2-[6-[3- 0.270 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 177 1-[(3S)-3-Fluoropyrrolidin-1-yl]-2-[6-[3- 0.393 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 178 (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro- 0.235 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1- yl)ethanone; 179 (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro- 0.062 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1- yl)ethanone; 180 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.036 yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone; 181 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.044 yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]ethanone; 182 (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro- 0.394 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1- yl)ethanone; 183 (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro- 0.089 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1- yl)ethanone; 184 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.193 [4,3-b]pyridin-1-yl]-1-(3-methoxypyrrolidin-1-yl)ethanone; 185 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- >2.99 yl]-1-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; 186 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- >2.99 yl]-1-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; 187 N-[(3S)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.106 [4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; 188 N-[(3R)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.083 [4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; 189 1-(3,3-Difluoropyrrolidin-1-yl)-2-[6-[3- 0.200 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 190 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.177 1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; 191 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.027 yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; 192 (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.318 [4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)ethanone; 193 (Racemic) Trans-2-[6-[3-(Difluoromethyl)-4-fluoro- 0.212 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-4-hydroxy- pyrrolidin-1-yl)ethanone; 194 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.146 [4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; 195 1-[2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo 0.351 [4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; 196 1-(1-Piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 0.200 [4,3-b]pyridin-1-yl]ethanone; 197 1-(4,4-Difluoro-1-piperidyl)-2-[6-[3- 1.280 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 198 N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.230 [4,3-b]pyridin-1-yl]acetyl]-4-piperidyl]acetamide; 199 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino- 0.800 ethanone; 200 1-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-3-yl]-2-[6-[3- 0.063 (difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- yl]ethanone; 201 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.361 yl]-1-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; 202 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.184 yl]-1-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; 203 (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro- 4.839 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3a,4,6,6a-tetrahydro-3H- pyrrolo[3,4-d]oxazol-2-one; 204 (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro- 0.795 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-1,3,3a,4,6,6a- hexahydropyrrolo[2,3-c]pyrrol-2-one; 205 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]- 0.066 N,N-dimethyl-acetamide; 206 N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo 0.020 [4,3-b]pyridin-1-yl]acetamide; 207 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.036 dimethyl-acetamide; 208 2-[6-(5-Chloro-4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]- 0.014 N,N-dimethyl-acetamide; 209 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.061 dimethyl-acetamide; 210 2-[6-[3-(Difluoromethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1- 0.033 yl]-N,N-dimethyl-acetamide; 211 2-[3-Fluoro-6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.098 dimethyl-acetamide; 212 2-[3-Fluoro-6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.089 dimethyl-acetamide; 213 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl- 0.071 acetamide; 214 N,N-Dimethyl-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo 0.324 [4,3-b]pyridin-1-yl]acetamide; 215 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.155 yl]-N-methyl-acetamide; 216 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.046 yl]-N-ethyl-acetamide; 217 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.070 yl]-N-ethyl-N-methyl-acetamide; 218 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.024 [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 219 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo 0.043 [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 220 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- 0.028 yl]-N,N-dimethyl-acetamide; 221 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.102 1-yl]-N,N-dimethyl-acetamide; 222 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N- 0.315 methyl-acetamide; 223 2-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1- 0.024 yl]-N,N-dimethyl-acetamide; 224 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.035 dimethyl-acetamide; 225 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.027 dimethyl-acetamide; 226 2-[6-(3,4-Dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N- 0.041 dimethyl-acetamide; 227 2-[6-(3,5-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]- 0.094 N,N-dimethyl-acetamide; 228 2-[6-[3,4-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]- 0.035 N,N-dimethyl-acetamide; 229 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]- 0.062 N,N-dimethyl-acetamide; 230 2-[6-[3-(1,1-Difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin- 0.078 1-yl]-N,N-dimethyl-acetamide; 231 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin- 0.020 1-yl]-N,N-dimethyl-acetamide; 232 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo 0.042 [4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 233 2-[6-[2-Fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1- 0.039 yl]-N,N-dimethyl-acetamide; 234 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 1.030 yl]-N-(2-methoxyethyl)-N-methyl-acetamide; 235 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 0.387 yl]-N-(2-hydroxyethyl)-N-methyl-acetamide; 236 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1- 1.470 yl]-N-methyl-N-(2,2,2-trifluoroethyl)acetamide; 237 N-(Cyanomethyl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.311 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; 238 N-Allyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo 0.166 [4,3-b]pyridin-1-yl]-N-methyl-acetamide; 239 N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1- 0.093 yl]acetamide; 240 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]- 0.016 N,N-dimethyl-acetamide; 241 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]- 0.014 N,N-dimethyl-acetamide; 242 N-Cyclopropyl-N-methyl-2-[6-[3- 0.145 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridine-1-yl]acetamide; 243 N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro- 0.031 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 244 N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro- 0.086 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; 245 N-Cyclopropyl-2-[3-methyl-6-[3- 0.561 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 246 N-Cyclopropyl-2-[6-[3-(difluoromethoxy)-4-fluoro- 0.085 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 247 N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro- 0.049 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 248 N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro- 0.150 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; 249 N-Cyclobutyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 1.120 [4,3-b]pyridin-1-yl]acetamide; 250 N-(3,3-Difluorocyclobutyl)-2-[6-[3- 0.900 (trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 251 N-(3,3-Difluorocyclobutyl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.160 phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 252 N-(3-Bicyclo[1.1.1]pentanyl)-2-[6-[3-(difluoromethyl)-4-fluoro- 0.394 phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; 253 N-(Oxetan-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo 2.210 [4,3-b]pyridin-1-yl]acetamide; 254 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo 0.066 [4,3-b]pyridin-1-yl)-1-(3-(pyridin-3-yl)azetidin-1-yl)ethan-1-one; 255 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo 0.096 [4,3-b]pyridin-1-yl)-1-(3-(pyridin-2-yl)azetidin-1-yl)ethan-1-one; 256 Methyl (1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H- 0.044 pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)carbamate; 257 (S)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H- 0.13 pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide; 258 (R)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H- 0.12 pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide; and 259 1-(3-(Fluoro-18F)azetidin-1-yl)-2-(6-(3-(trifluoromethyl)phenyl)- NT 1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one. NT means not tested

Protocol for Liver Microsomal Stability (Extraction Ratio) Liver Microsomal Stability.

Microsomal stability studies (Chrovian et al, “1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators”. ACS Med Chem Lett. 2019 Jan. 10; 10(3):261-266) were conducted on a Biomek® FX Robotic Liquid Handling Workstation (Beckman Coulter, Brea, Calif.), which consists of a 96-channel pipette head, a 12-position workstation deck, and a plate incubator. Test compounds (1 μm) were spiked in a reaction mix consisting of 100 mM potassium phosphate buffer (pH 7.4), 3 mM MgCl₂, and 0.5 mg/mL liver microsomes from mouse, rat, and human (BD Gentest). The reaction was brought to 37° C. and initiated by adding NADPH to a final concentration of 1 mM. After mixing on the platedeck, 50 μL aliquots were excised from the reaction plate at 0, 5, 10, 20, 40, and 60 min and quenched with four volumes of acetonitrile spiked with 500 μg/nL of the internal standard phenytoin. Quenched plates were centrifuged at 5700 rpm for 10 min at 4° C., and supernatant was diluted 1:3 in water before LC/MS/MS analysis. The compound half-lives were derived from plots of the ln of percent remaining compound over time to determine the intrinsic clearance. The predicted hepatic clearance was derived from the intrinsic clearance value using equations from the well-stirred model (Current Drug Metabolism, 2008, 9, 940-951), where no correction was made plasma protein binding and the blood to plasma concentration ratio was assumed to be one. The extraction ratio (ER) was calculated by dividing the predicted hepatic clearance by species blood flow (Q), where Q is 90, 55, and 21.7 mL/min/kg for mouse, rat and human, respectively.

Results of the assay performed on the compounds of Examples are shown in Table 4.

Extraction Ratio @ Example # 1 μM  5  <0.298  6  0.42  7  0.63  9  <0.298  35  0.42  41  0.30  70  <0.298  76  <0.298  79  <0.298 141  <0.298

SPECIFIC EMBODIMENTS

The present disclosure is exemplified by the specific embodiments 1-40 below.

-   1. A compound, having the structure of Formula (I):

wherein

-   -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN;             NH₂; NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted             with two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;     -   n is 1 or 2; and     -   m is 1 or 2;     -   and pharmaceutically acceptable salts, solvates, stereoisomers,         isotopic variants, or N-oxides thereof.

-   2. The compound of embodiment 1, wherein R¹ is H.

-   3. The compound of embodiment 1, wherein R¹ is F.

-   4. The compound of embodiment 1, wherein R¹ is CH₃.

-   5. The compound of embodiment 1, wherein Ar¹ is phenyl substituted     with one member selected from the group consisting of: Cl, F, CH₃,     OCH₃, CH₂F, CHF₂, CF₃, CHF₂CH₃, OCHF₂, CN, and cyclopropyl.

-   6. The compound of embodiment 1, wherein Ar¹ is selected from the     group consisting of:

-   7. The compound of embodiment 1, wherein Ar¹ is phenyl substituted     with two members each independently selected from the group     consisting of: Cl, F, CH₃, CHF₂, CF₃, CHF₂CH₃, OCH₃, OCHF₂, and     (C═O)CH₃. -   8. The compound of embodiment 1, wherein Ar¹ is selected from the     group consisting of:

-   9. The compound of embodiment 1, wherein Ar¹ is phenyl substituted     with three members each independently selected from the group     consisting of: halo, and CH₃. -   10. The compound of embodiment 1, wherein Ar¹ is selected from the     group consisting of:

-   11. The compound of embodiment 1, wherein Ar¹ is thienyl     independently substituted with one or two members selected from: Cl,     CH₃, CF₃ and CHF₂. -   12. The compound of embodiment 1, wherein Ar¹ is selected from the     group consisting of:

-   13. The compound of embodiment 1, wherein Ar¹ is selected from the     group consisting of:

-   14. The compound of embodiment 1, wherein R² is

wherein

-   -   R^(a) is each independently selected from the group consisting         of: H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃, ═CH₂, CH═CH₂,         CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH, CH(OH)(CH₃),         CH₂OCH₃, OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃), NHCO₂CH₃,         NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃,         C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃, SO₂CH₃, 1H-imidazol-2-yl,         2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and         pyrrolidine-2-one; or two R^(a) members combine to form a         cyclopropyl, cyclobutyl, or oxetanyl; wherein the cyclopropyl is         optionally substituted one or two F members;     -   and n is 1 or 2.

-   15. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   16. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   17. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   18. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   19. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   20. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   21. The compound of embodiment 1, wherein R² is selected from the     group consisting of:

-   22. The compound of embodiment 1 wherein R² is selected from the     group consisting of:

-   23. The compound of embodiment 1, wherein n is 1. -   24. The compound of embodiment 1, wherein n is 2. -   25. The compound of embodiment 1, wherein m is 1. -   26. The compound of embodiment 1, wherein m is 2. -   27. The compound of embodiment 1, having the structure of Formula     (IA):

-   -   wherein     -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R^(a) is each independently selected from the group consisting         of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl, C₂₋₆alkenyl,         C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH, CH(OH)(CH₃), CH₂OCH₃,         OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃), NHCO₂CH₃, NHC(═O)CH₃,         NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂,         C(═O)CH₃, CN, NHSO₂CH₃, SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl,         3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and pyrrolidine-2-one; or         two R^(a) members combine to form a C₃₋₆cycloalkyl or         heterocycloalkyl, wherein the C₃₋₆cycloalkyl and         heterocycloalkyl is optionally substituted one or two F members;         and     -   n is 1 or 2;     -   and pharmaceutically acceptable salts, solvates, stereoisomers,         isotopic variants, or N-oxides thereof.

-   28. The compound of embodiment 27, wherein     -   R¹ is H, F, or CH₃;     -   Ar¹ is phenyl substituted with two or three members each         independently selected from the group consisting of: halo,         C₁₋₄alkyl, C₁₋₄perhaloalkyl, OC₁₋₄alkyl, and OC₁₋₄perhaloalkyl;     -   R^(a) is each independently selected from the group consisting         of: H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃, ═CH₂, CH═CH₂,         CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH, CH(OH)(CH₃),         CH₂OCH₃, OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃), NHCO₂CH₃,         NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃,         C(═O)CH₃, CN, NHSO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl,         4-pyridyl, pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a)         members combine to form a cyclopropyl, cyclobutyl, or oxetanyl;         wherein the cyclopropyl is optionally substituted one or two F         members;     -   and n is 1 or 2.

-   29. The compound of embodiment 27, wherein R¹ is H.

-   30. The compound of embodiment 1, having the structure of Formula     (IB):

-   -   wherein     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   Ring

-   -    is selected from the group consisting of:

-   -   -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;         -   n is 1 or 2; and         -   m is 1 or 2;

    -   and pharmaceutically acceptable salts, solvates, stereoisomers,         isotopic variants, or N-oxides thereof.

-   31. The compound of embodiment 30, wherein Ring

is

-   32. The compound of embodiment 1, having the structure of Formula     (IC):

-   -   wherein     -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;         CH₂CH═CH₂; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;         NH—C(═O)CH₃; cyclopropyl; cyclobutyl; 3-bicyclo[1.1.1]pentanyl;         3,3-difluorocyclobutyl; 1-methylazetidin-3-yl; and oxetan-3-yl;         and     -   R^(e) is H or CH₃;         -   and pharmaceutically acceptable salts, solvates,             stereoisomers, isotopic variants, or N-oxides thereof.

-   33. The compound of embodiment 32, wherein Ar¹ is

-   34. A compound selected from the group consisting of: -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methyleneazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone;     N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-N-methyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone; -   1-Morpholino-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-(1-Methylazetidin-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[5-(difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(3-chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(2,3-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(3-chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(3-Acetyl-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(azetidin-1-yl)ethanone; -   1-(Azetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[5-(Difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(2,3-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(2,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(3,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(3,5-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(3-Chloro-4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(3-Chloroazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   (Racemic)     1-(2-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; -   (Racemic)     2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(2-methylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethynylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-vinylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-prop-1-enyl]azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(fluoromethyl)azetidin-1-yl]ethanone; -   1-[3-(Difluoromethyl)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-[3-(Trifluoromethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethyl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-2-fluorovinyl]azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(2,2-difluorovinyl)azetidin-1-yl]ethanone; -   1-(3-Methoxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxyazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethoxyazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methoxymethyl)azetidin-1-yl]ethanone; -   1-[3-(Methoxymethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   (Racemic)     2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1-hydroxyethyl)azetidin-1-yl]ethanone; -   1-[3-(Difluoromethoxy)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethoxy)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; -   1-(3-Hydroxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(hydroxymethyl)azetidin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   3-[1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]pyrazolo[4,3-b]pyridin-6-yl]benzonitrile; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-3-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,     5-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; -   2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-5-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-methyl-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3,3-Dimethylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(3-Fluoro-3-methyl-azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-dimethylazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-fluoro-azetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(fluoromethyl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxy-3-methyl-azetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-hydroxy-azetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-azetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(hydroxymethyl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(methoxymethyl)azetidin-1-yl]ethanone; -   [6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-2-methyl-azetidin-1-yl)ethanone; -   1-[2-[6-[3-(Trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile; -   1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile; -   1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3-methyl-azetidine-3-carbonitrile; -   1-(3-Acetylazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]acetamide; -   1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-N,N-dimethyl-azetidine-3-carboxamide; -   MethylN-[1-[2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]carbamate; -   N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-2,2,2-trifluoro-acetamide; -   N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]cyclopropanecarboxamide; -   N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]methanesulfonamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylsulfonylazetidin-1-yl)ethanone; -   1-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]pyrrolidin-2-one; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1H-imidazol-2-yl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(4-pyridyl)azetidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-pyrimidin-4-ylazetidin-1-yl)ethanone; -   1-(5-Azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(2,2-Difluoro-5-azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(6-Azaspiro[3.3]heptan-6-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-oxa-6-azaspiro[3.3]heptan-6-yl)ethanone; -   1-(6-Oxa-2-azaspiro[3.3]heptan-2-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; -   1-Pyrrolidin-1-yl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-(3-Cyclopropylphenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; -   2-[6-(3,     5-Difluoro-4-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; -   1-[(3R)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-[(3S)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   (Racemic)     (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone; -   (Racemic)     (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]ethanone; -   (Racemic)     (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone; -   (Racemic)     (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone; -   (Racemic)     2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxypyrrolidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; -   N-[(3S)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; -   N-[(3R)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; -   1-(3,3-Difluoropyrrolidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; -   (Racemic)     2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)ethanone; -   (Racemic)     Trans-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-4-hydroxy-pyrrolidin-1-yl)ethanone; -   1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; -   1-[2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; -   1-(1-Piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(4,4-Difluoro-1-piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-4-piperidyl]acetamide; -   2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone; -   1-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-3-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; -   (Racemic)     Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3a,4,6,6a-tetrahydro-3H-pyrrolo[3,4-d]oxazol-2-one; -   (Racemic)     Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-2-one; -   2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(5-Chloro-4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[3-Fluoro-6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[3-Fluoro-6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   N,N-Dimethyl-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-N-methyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   2-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(3,4-Dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(3,     5-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(3,4-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(1,1-Difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[2-Fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-methoxyethyl)-N-methyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-hydroxyethyl)-N-methyl-acetamide; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-N-(2,2,2-trifluoroethyl)acetamide; -   N-(Cyanomethyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   N-Allyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   N-Cyclopropyl-N-methyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   N-Cyclopropyl-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-Cyclopropyl-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   N-Cyclobutyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-(3,3-Difluorocyclobutyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-(3,3-Difluorocyclobutyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   N-(3-Bicyclo[1.1.1]pentanyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; -   N-(Oxetan-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; -   2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-3-yl)azetidin-1-yl)ethan-1-one; -   2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-2-yl)azetidin-1-yl)ethan-1-one; -   Methyl     (1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)carbamate; -   (S)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide; -   (R)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide;     and -   1-(3-(Fluoro-18F)azetidin-1-yl)-2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one; -   and pharmaceutically acceptable salts, solvates, stereoisomers,     isotopic variants, or N-oxides thereof. -   35. A compound selected from the group consisting of: -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; -   2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; -   2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone;     and -   2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone;     -   and pharmaceutically acceptable salts, solvates, stereoisomers,         isotopic variants, or N-oxides thereof. -   36. A pharmaceutical composition comprising: (A) an effective amount     of at least one compound selected from compounds of Formula (I)

-   -   wherein     -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2;

    -   and pharmaceutically acceptable salts, stereoisomers, isotopic         variants, N-oxides, or solvates of compounds of Formula (I);

    -   (B) at least one pharmaceutically acceptable excipient.

-   37. A pharmaceutical composition comprising an effective amount of     at least one compound of embodiment 34 and at least one     pharmaceutically acceptable excipient.

-   38. A method of treating a subject suffering from or diagnosed with     a disease, disorder, or medical condition mediated by GluN2B     receptor activity, comprising administering to a subject in need of     such treatment an effective amount of at least one compound selected     from compounds of Formula (I):

-   -   wherein     -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;             NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted with             two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2;

    -   and pharmaceutically acceptable salts, stereoisomers, isotopic         variants, N-oxides, or solvates of compounds of Formula (I).

-   39. The method of embodiment 38, wherein the disorder, disease or     condition mediated by the GluN2B receptor is selected from the group     consisting of: bipolar disorder, major depressive disorder,     treatment-resistant depression, post-partum depression, seasonal     affective disorder, Alzheimer's disease, Parkinson's disease,     Huntington's chorea, multiple sclerosis, cognitive impairment, head     injury, spinal cord injury, stroke, epilepsy, dyskinesias,     amyotrophic lateral sclerosis, neurodegeneration associated with     bacterial or chronic infections, pain, diabetic neuropathy,     migraine, cerebral ischemia, schizophrenia, encephalitis, autism and     autism spectrum disorders, memory and learning disorders, obsessive     compulsive disorder, attention deficit hyperactivity disorder (ADHD)     and addictive illnesses.

-   40. The method of embodiment 38, wherein the disorder, disease or     condition is selected from the group consisting of     treatment-resistant depression, major depressive disorder and     bipolar disorder.

The present disclosure is further exemplified by the specific embodiments 1-58 below.

-   -   1. A compound, having the structure of Formula (I):

-   -   or a pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof,     -   wherein     -   R¹ is H, halo, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl substituted with one or two members             independently selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R² is selected from the group consisting of:

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the cycloalkyl and heterocycloalkyl is optionally             substituted one or two F members;

-   -   -    wherein         -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;

-   -   -    wherein         -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;             C₂₋₆alkenyl; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN;             NH₂; NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆cycloalkyl substituted             with two F members; 1-methylazetidin-3-yl; and oxetan-3-yl;         -   R^(e) is H or CH₃;

    -   n is 1 or 2; and

    -   m is 1 or 2.

    -   2. The compound of embodiment 1 or a pharmaceutically acceptable         salt, solvate, stereoisomer, isotopic variant, or N-oxide         thereof, wherein R² is H.

    -   3. The compound of embodiment 1 or a pharmaceutically acceptable         salt, solvate, stereoisomer, isotopic variant, or N-oxide         thereof, wherein R² is F.

    -   4. The compound of embodiment 1 or a pharmaceutically acceptable         salt, solvate, stereoisomer, isotopic variant, or N-oxide         thereof, wherein R² is CH₃.

    -   5. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl         substituted with one member selected from the group consisting         of: Cl, F, CH₃, OCH₃, CH₂F, CHF₂, CF₃, CHF₂CH₃, OCHF₂, CN, and         cyclopropyl.

    -   6. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is selected         from the group consisting of:

-   -   7. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl         substituted with two members each independently selected from         the group consisting of: Cl, F, CH₃, CHF₂, CF₃, CHF₂CH₃, OCH₃,         OCHF₂, and (C═O)CH₃.     -   8. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is selected         from the group consisting of:

-   -   9. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl         substituted with three members each independently selected from         the group consisting of: halo, and CH₃.     -   10. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is selected         from the group consisting of:

-   -   11. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is thienyl         substituted with one or two members independently selected from:         Cl, CH₃, CF₃ and CHF₂.     -   12. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is selected         from the group consisting of:

-   -   13. The compound of any one of embodiments 1 to 4, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein Ar¹ is selected         from the group consisting of:

-   -   14. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is

-   -    wherein         -   R^(a) is each independently selected from the group             consisting of: H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃,             ═CH₂, CH═CH₂, CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a cyclopropyl, cyclobutyl, or oxetanyl;             wherein the cyclopropyl is optionally substituted one or two             F members;         -   and n is 1 or 2.     -   15. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   16. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   17. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   18. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   19. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   20. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   21. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   22. The compound of any one of embodiments 1 to 13, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R² is selected         from the group consisting of:

-   -   23. The compound of any one of embodiments 1 to 22, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein n is 1.     -   24. The compound of any one of embodiments 1 to 22, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein n is 2.     -   25. The compound of any one of embodiments 1 to 24, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein m is 1.     -   26. The compound of any one of embodiments 1 to 24, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein m is 2.     -   27. The compound of embodiment 1 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, having the structure of Formula (IA):

-   -   wherein     -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl,             C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl,             and (C═O)CH₃; and         -   (c) thienyl substituted with one or two members             independently selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;         -   R^(a) is each independently selected from the group             consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl,             C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃,             SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl,             pyrimidin-4-yl, and pyrrolidine-2-one; or two R^(a) members             combine to form a C₃₋₆cycloalkyl or heterocycloalkyl,             wherein the C₃₋₆cycloalkyl and heterocycloalkyl is             optionally substituted one or two F members; and     -   n is 1 or 2.     -   28. The compound of embodiment 27 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, wherein         -   R¹ is H, F, or CH₃;         -   Ar¹ is phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₄alkyl, C₁₋₄perhaloalkyl, OC₁₋₄alkyl, and             OC₁₋₄perhaloalkyl;         -   R^(a) is each independently selected from the group             consisting of: H, Cl, F, OH, CH₃, CH₂CH₃, CH₂F, CHF₂, CF₃,             ═CH₂, CH═CH₂, CH═CH(CH₃), CH═CH(F), CH═CF(F), C═CH, CH₂OH,             CH(OH)(CH₃), CH₂OCH₃, OCHF₂, OCF₃, OCH₃, OCH₂CH₃, NH(CH₃),             NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl,             N(CH₃)C(═O)CH₃, C(═O)CH₃, CN, NHSO₂CH₃, 1H-imidazol-2-yl,             2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and             pyrrolidine-2-one; or two R^(a) members combine to form a             cyclopropyl, cyclobutyl, or oxetanyl; wherein the             cyclopropyl is optionally substituted one or two F members;     -   and n is 1 or 2.     -   29. The compound of embodiment 27 or embodiment 28, or a         pharmaceutically acceptable salt, solvate, stereoisomer,         isotopic variant, or N-oxide thereof, wherein R¹ is H.     -   30. The compound of embodiment 1 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, having the structure of Formula (IB):

-   -   wherein     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   Ring

-   -    is selected from the group consisting of:

-   -   -   R^(b) is each independently selected from the group             consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or             two R^(b) members come together to form ═O;         -   n is 1 or 2; and         -   m is 1 or 2.

    -   31. The compound of embodiment 30 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, wherein Ring

-   -    is

-   -   32. The compound of embodiment 1 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, having the structure of Formula (IC):

-   -   wherein     -   R¹ is H, F, or CH₃;     -   Ar¹ is selected from the group consisting of:         -   (a) phenyl substituted with one member selected from the             group consisting of: halo, and C₁₋₆perhaloalkyl;         -   (b) phenyl substituted with two or three members each             independently selected from the group consisting of: halo,             C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and         -   (c) thienyl independently substituted with one or two             members selected from: halo, C₁₋₆alkyl, and             C₁₋₆perhaloalkyl; and pyridine substituted with CF₃;     -   R^(d) is selected from the group consisting of: C₁₋₆alkyl;         CH₂CH═CH₂; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂;         NH—C(═O)CH₃; cyclopropyl; cyclobutyl; 3-bicyclo[1.1.1]pentanyl;         3,3-difluorocyclobutyl; 1-methylazetidin-3-yl; and oxetan-3-yl;         and     -   R^(e) is H or CH₃.     -   33. The compound of embodiment 32 or a pharmaceutically         acceptable salt, solvate, stereoisomer, isotopic variant, or         N-oxide thereof, wherein Ar¹ is

-   -   34. A compound selected from the compounds in Table 1 and         pharmaceutically acceptable salts, solvates, stereoisomers,         isotopic variants, and N-oxides thereof.     -   35. The compound of any one of embodiments 1 to 34, or a         pharmaceutically acceptable salt or solvate thereof.     -   36. The compound of any one of embodiments 1 to 34, or a         pharmaceutically acceptable salt or N-oxide thereof.     -   37. The compound of any one of embodiments 1 to 34, or a         pharmaceutically acceptable salt thereof.     -   38. The compound of any one of embodiments 1 to 34.     -   39. A pharmaceutically acceptable salt of the compound of any         one of embodiments 1 to 34.     -   40. A pharmaceutical composition comprising the compound of any         one of embodiments 1 to 34, or a pharmaceutically acceptable         salt, solvate, isotopic variant, or N-oxide thereof, and a         pharmaceutically acceptable excipient.     -   41. A pharmaceutical composition comprising the compound of any         one of embodiments 1 to 34, or a pharmaceutically acceptable         salt or solvate thereof, and a pharmaceutically acceptable         excipient.     -   42. A pharmaceutical composition comprising the compound of any         one of embodiments 1 to 34, or a pharmaceutically acceptable         salt or N-oxide thereof, and a pharmaceutically acceptable         excipient.     -   43. A pharmaceutical composition comprising the compound of any         one of embodiments 1 to 34, or a pharmaceutically acceptable         salt thereof, and a pharmaceutically acceptable excipient.     -   44. A pharmaceutical composition comprising the compound of any         one of embodiments 1 to 34 and a pharmaceutically acceptable         excipient.     -   45. A pharmaceutical composition comprising a pharmaceutically         acceptable salt of the compound of any one of embodiments 1 to         34, and a pharmaceutically acceptable excipient.     -   46. A unit dosage form comprising a therapeutically effective         amount of the pharmaceutical composition of any one of         embodiments 40 to 45.     -   47. A method of treating a subject suffering from or diagnosed         with a disease, disorder, or medical condition mediated by         GluN2B receptor activity, comprising administering to the         subject a therapeutically effective amount of the compound of         any one of embodiments 1 to 34, or a pharmaceutically acceptable         salt, solvate, isotopic variant, or N-oxide thereof.     -   48. A method of treating a subject suffering from or diagnosed         with a disease, disorder, or medical condition mediated by         GluN2B receptor activity, comprising administering to the         subject a therapeutically effective amount of the compound of         any one of embodiments 1 to 34, or a pharmaceutically acceptable         salt, or solvate thereof.     -   49. A method of treating a subject suffering from or diagnosed         with a disease, disorder, or medical condition mediated by         GluN2B receptor activity, comprising administering to the         subject a therapeutically effective amount of the compound of         any one of embodiments 1 to 34, or a pharmaceutically acceptable         salt or N-oxide thereof.     -   50. A method of treating a subject suffering from or diagnosed         with a disease, disorder, or medical condition mediated by         GluN2B receptor activity, comprising administering to the         subject a therapeutically effective amount of the compound of         any one of embodiments 1 to 34, or a pharmaceutically acceptable         salt thereof.     -   51. A method of treating a subject suffering from or diagnosed         with a disease, disorder, or medical condition mediated by         GluN2B receptor activity, comprising administering to the         subject a therapeutically effective amount of the pharmaceutical         composition of any one of embodiments 40 to 45 or the unit         dosage form of embodiment 46.     -   52. The method of any one of embodiments 47 to 51, wherein the         disease, disorder or medical condition mediated by GluN2B         receptor activity comprises bipolar disorder, major depressive         disorder, treatment-resistant depression, a mood disorder,         post-partum depression, seasonal affective disorder, Alzheimer's         disease, Parkinson's disease, Huntington's chorea, multiple         sclerosis, cognitive impairment, head injury, spinal cord         injury, stroke, epilepsy, dyskinesias, amyotrophic lateral         sclerosis, neurodegeneration associated with a bacterial or         chronic infection, pain, diabetic neuropathy, migraine, cerebral         ischemia, schizophrenia, encephalitis, autism or an autism         spectrum disorder, a memory disorder, a learning disorder,         obsessive compulsive disorder, attention deficit hyperactivity         disorder (ADHD) or an addictive illness.     -   53. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises bipolar disorder, a mood disorder, treatment resistant         depression, major depressive disorder, or epilepsy.     -   54. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises bipolar disorder.     -   55. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises a mood disorder.     -   56. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises treatment resistant depression.     -   57. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises major depressive disorder.     -   58. The method of embodiment 52, wherein the disease, disorder         or medical condition mediated by GluN2B receptor activity         comprises epilepsy. 

1. A compound having the structure of Formula (I):

or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein: R¹ is H, halo, or CH₃; Ar¹ is selected from the group consisting of: (a) phenyl substituted with one member selected from the group consisting of: halo, C₁₋₆alkyl, OC₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl, CN, and C₃₋₆cycloalkyl; (b) phenyl substituted with two or three members each independently selected from the group consisting of: halo, C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆alkyl, OC₁₋₆perhaloalkyl, and (C═O)CH₃; and (c) thienyl substituted with one or two members independently selected from: halo, C₁₋₆alkyl, and C₁₋₆perhaloalkyl; and pyridine substituted with CF₃; R² is selected from the group consisting of: (a)

 wherein each R^(a) is independently selected from the group consisting of: H, halo, OH, C₁₋₆alkyl, C₁₋₆haloalkyl, C₂₋₆alkenyl, C₂₋₆haloalkenyl, C₂₋₆alkynyl, CH₂OH, CH(OH)(CH₃), CH₂OCH₃, OC₁₋₆haloalkyl, OC₁₋₆alkyl, NH(CH₃), NHCO₂CH₃, NHC(═O)CH₃, NHC(═O)CF₃, NHC(═O)cyclopropyl, N(CH₃)C(═O)CH₃, C(═O)N(CH₃)₂, C(═O)CH₃, CN, NHSO₂CH₃, SO₂CH₃, 1H-imidazol-2-yl, 2-pyridyl, 3-pyridyl, 4-pyridyl, pyrimidin-4-yl, and pyrrolidin-2-on-1-yl; or two R^(a) members combine to form a C₃₋₆cycloalkyl or heterocycloalkyl, wherein the cycloalkyl and heterocycloalkyl are optionally substituted one or two F members; (b)

 wherein each R^(b) is independently selected from the group consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or two R^(b) members come together to form ═O; (c)

and (d)

 wherein R^(d) is selected from the group consisting of: C₆alkyl; C₂₋₆alkenyl; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂; NH—C(═O)CH₃; C₃₋₆cycloalkyl; C₃₋₆ cycloalkyl substituted with two F members; 1-methylazetidin-3-yl; and oxetan-3-yl; R^(e) is H or CH₃; n is 1 or 2; and m is 1 or
 2. 2. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R¹ is H.
 3. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is F.
 4. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is CH₃.
 5. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl substituted with one member selected from the group consisting of: Cl, F, CH₃, OCH₃, CH₂F, CHF₂, CF₃, CHF₂CH₃, OCHF₂, CN, and cyclopropyl.
 6. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is selected from the group consisting of:


7. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl substituted with two members each independently selected from the group consisting of: C, F, CH₃, CHF₂, CF₃, CHF₂CH₃, OCH₃, OCHF₂, and (C═O)CH₃.
 8. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is selected from the group consisting of:


9. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is phenyl substituted with three members each independently selected from the group consisting of: halo and CH₃.
 10. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is selected from the group consisting of:


11. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is thienyl substituted with one or two members independently selected from: Cl, CH₃, CF₃, and CHF₂.
 12. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is selected from the group consisting of:


13. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is selected from the group consisting of:

14-18. (canceled)
 19. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is selected from the group consisting of:


20. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is selected from the group consisting of:


21. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is selected from the group consisting of:


22. The compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein R² is selected from the group consisting of:

23-25. (canceled)
 26. The compound of claim 1 having the structure of Formula (IB):

or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein: Ar¹ is selected from the group consisting of: (a) phenyl substituted with one member selected from the group consisting of: halo, and C₁₋₆perhaloalkyl; (b) phenyl substituted with two or three members each independently selected from the group consisting of: halo, C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and (c) thienyl independently substituted with one or two members selected from: halo, C₁₋₆alkyl, and C₁₋₆perhaloalkyl; and pyridine substituted with CF₃; Ring

 is selected from the group consisting of:

each R^(b) is independently selected from the group consisting of: H, OH, F, OCH₃, CH₂OCH₃, and NHC(═O)CH₃; or two R^(b) members come together to form ═O; n is 1 or 2; and m is 1 or
 2. 27. The compound of claim 26 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ring

is


28. The compound of claim 1 having the structure of Formula (IC):

or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein: R¹ is H, F, or CH₃; Ar¹ is selected from the group consisting of: (a) phenyl substituted with one member selected from the group consisting of: halo, and C₁₋₆perhaloalkyl; (b) phenyl substituted with two or three members each independently selected from the group consisting of: halo, C₁₋₆alkyl, C₁₋₆perhaloalkyl, OC₁₋₆perhaloalkyl; and (c) thienyl independently substituted with one or two members selected from: halo, C₁₋₆alkyl, and C₁₋₆perhaloalkyl; and pyridine substituted with CF₃; R^(d) is selected from the group consisting of: C₁₋₆alkyl; CH₂CH═CH₂; C₁₋₆haloalkyl; CH₂CH₂OCH₃; CH₂CH₂OH; CH₂CN; NH₂; NH—C(═O)CH₃; cyclopropyl; cyclobutyl; 3-bicyclo[1.1.1]pentanyl; 3,3-difluorocyclobutyl; 1-methylazetidin-3-yl; and oxetan-3-yl; and R^(e) is H or CH₃.
 29. The compound of claim 28 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, wherein Ar¹ is


30. A compound selected from the group consisting of: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4-3-b]pyridin-1-yl]-1-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methyleneazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methylamino)azetidin-1-yl]ethanone; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-N-methyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; N,N-Dimethyl-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone; 1-Morpholino-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-(1-Methylazetidin-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(5-chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[5-(difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(3-chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(3,4-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(2,3-dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(3-chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(1,1-difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(4-chloro-3-methylphenyl)-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[4-chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(3-Acetyl-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(azetidin-1-yl)ethanone; 1-(Azetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(5-Chloro-2-thienyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[5-(Difluoromethyl)-2-thienyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[3-fluoro-6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-[3-(fluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(2,3-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(2,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(3,4-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(3,5-Difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(3-Chloro-4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(3-Chloroazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(1,1-difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; (Racemic) 1-(2-Methylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(2-methylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethynylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-vinylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-prop-1-enyl]azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(fluoromethyl)azetidin-1-yl]ethanone; 1-[3-(Difluoromethyl)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-[3-(Trifluoromethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethyl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-[(Z)-2-fluorovinyl]azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(2,2-difluorovinyl)azetidin-1-yl]ethanone; 1-(3-Methoxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxyazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethoxyazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(methoxymethyl)azetidin-1-yl]ethanone; 1-[3-(Methoxymethyl)azetidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1-hydroxyethyl)azetidin-1-yl]ethanone; 1-[3-(Difluoromethoxy)azetidin-1-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(trifluoromethoxy)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxyazetidin-1-yl)ethanone; 1-(3-Hydroxyazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(hydroxymethyl)azetidin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(m-tolyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 3-[1-[2-(3,3-Difluoroazetidin-1-yl)-2-oxo-ethyl]pyrazolo[4,3-b]pyridin-6-yl]benzonitrile; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[6-(trifluoromethyl)-2-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[5-(trifluoromethyl)-3-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,5-difluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 2-[6-(3-Chloro-2-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoroazetidin-1-yl)ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(2-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-fluoro-5-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-[2-methyl-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(4-fluoro-2-methoxy-phenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Difluoroazetidin-1-yl)-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3,3-Dimethylazetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(3-Fluoro-3-methyl-azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-dimethylazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-fluoro-azetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(fluoromethyl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxy-3-methyl-azetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-ethyl-3-hydroxy-azetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-azetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(hydroxymethyl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-fluoro-3-(methoxymethyl)azetidin-1-yl]ethanone; [6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-2-methyl-azetidin-1-yl)ethanone; 1-[2-[6-[3-(Trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile; 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidine-3-carbonitrile; 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3-methyl-azetidine-3-carbonitrile; 1-(3-Acetylazetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]acetamide; 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-N,N-dimethyl-azetidine-3-carboxamide; MethylN-[1-[2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]carbamate; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]-2,2,2-trifluoro-acetamide; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]cyclopropanecarboxamide; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]methanesulfonamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methylsulfonylazetidin-1-yl)ethanone; 1-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]azetidin-3-yl]pyrrolidin-2-one; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(1H-imidazol-2-yl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[3-(4-pyridyl)azetidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-pyrimidin-4-ylazetidin-1-yl)ethanone; 1-(5-Azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(2,2-Difluoro-5-azaspiro[2.3]hexan-5-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(6-Azaspiro[3.3]heptan-6-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-oxa-6-azaspiro[3.3]heptan-6-yl)ethanone; 1-(6-Oxa-2-azaspiro[3.3]heptan-2-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 1-Pyrrolidin-1-yl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-(3-Cyclopropylphenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 2-[6-(3,5-Difluoro-4-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-pyrrolidin-1-yl-ethanone; 1-[(3R)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-[(3S)-3-Fluoropyrrolidin-1-yl]-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone; (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoropyrrolidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]ethanone; (Racemic) (R,S)-2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone; (Racemic) (R,S)-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxypyrrolidin-1-yl)ethanone; (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-methoxypyrrolidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]ethanone; N-[(3S)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; N-[(3R)-1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-yl]acetamide; 1-(3,3-Difluoropyrrolidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3,3-difluoropyrrolidin-1-yl)ethanone; (Racemic) 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)ethanone; (Racemic) Trans-2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-4-hydroxy-pyrrolidin-1-yl)ethanone; 1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; 1-[2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]pyrrolidin-3-one; 1-(1-Piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(4,4-Difluoro-1-piperidyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; N-[1-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-4-piperidyl]acetamide; 2-[6-(4-Fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-1-morpholino-ethanone; 1-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-3-yl]-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]ethanone; (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-3a,4,6,6a-tetrahydro-3H-pyrrolo[3,4-d]oxazol-2-one; (Racemic) Cis-5-[2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-2-one; 2-[6-[5-(Difluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-[6-(5-Chloro-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(5-Chloro-4-methyl-2-thienyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(Difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(Difluoromethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[3-Fluoro-6-(4-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[3-Fluoro-6-(3-fluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(3-Chlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; N,N-Dimethyl-2-[6-[2-(trifluoromethyl)-4-pyridyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-ethyl-N-methyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-methyl-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(1,1-Difluoroethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; 2-[3-Fluoro-6-(4-fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(4-Chloro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N, N-dimethyl-acetamide; 2-[6-(3-Chloro-4-fluoro-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N, N-dimethyl-acetamide; 2-[6-(3,4-Dichlorophenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(3,5-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(3,4-Difluorophenyl)-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(1,1-Difluoroethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(1,1-Difluoroethyl)phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N, N-dimethyl-acetamide; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[2-Fluoro-3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-methoxyethyl)-N-methyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-(2-hydroxyethyl)-N-methyl-acetamide; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-N-(2,2,2-trifluoroethyl)acetamide; N-(Cyanomethyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; N-Allyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; N,N-Dimethyl-2-[6-(3,4,5-trifluorophenyl)pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-[6-(3,4-Difluoro-5-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(2,4-Difluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; N-Cyclopropyl-N-methyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-Cyclopropyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; N-Cyclopropyl-2-[3-methyl-6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-Cyclopropyl-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-Cyclobutyl-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; N-Cyclobutyl-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-(3,3-Difluorocyclobutyl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-(3,3-Difluorocyclobutyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; N-(3-Bicyclo[1.1.1]pentanyl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N-methyl-acetamide; N-(Oxetan-3-yl)-2-[6-[3-(trifluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]acetamide; 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-3-yl)azetidin-1-yl)ethan-1-one; 2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)-1-(3-(pyridin-2-yl)azetidin-1-yl)ethan-1-one; Methyl (1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)azetidin-3-yl)carbamate; (S)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide; (R)-N-(1-(2-(6-(3-(Difluoromethyl)-4-fluorophenyl)-3-fluoro-1H-pyrazolo[4,3-b]pyridin-1-yl)acetyl)pyrrolidin-3-yl)acetamide; 1-(3-(Fluoro-18F)azetidin-1-yl)-2-(6-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one; and pharmaceutically acceptable salts, solvates, stereoisomers, isotopic variants, and N-oxides thereof.
 31. A compound selected from the group consisting of: 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-(4-Fluoro-3-methyl-phenyl)pyrazolo[4,3-b]pyridin-1-yl]-N,N-dimethyl-acetamide; 2-[6-[4-Chloro-3-(difluoromethoxy)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 1-(Azetidin-1-yl)-2-[6-[3-(difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]-3-fluoro-pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[4-Chloro-3-(difluoromethyl)phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethoxy)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoroazetidin-1-yl)ethanone; 2-[6-[3-(Difluoromethyl)-4-fluoro-phenyl]pyrazolo[4,3-b]pyridin-1-yl]-1-(3-fluoro-3-methyl-azetidin-1-yl)ethanone; and pharmaceutically acceptable salts, solvates, stereoisomers, isotopic variants, and N-oxides thereof.
 32. A pharmaceutical composition comprising: (A) the compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof, and (B) at least one pharmaceutically acceptable excipient.
 33. A method of treating a subject suffering from or diagnosed with a disease, disorder, or medical condition mediated by GuN2B receptor activity, comprising administering to a subject in need of such treatment an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt, solvate, stereoisomer, isotopic variant, or N-oxide thereof.
 34. The method of claim 33, wherein the disease, disorder, or medical condition mediated by the GluN21B receptor is selected from the group consisting of: bipolar disorder, major depressive disorder, treatment-resistant depression, post-partum depression, seasonal affective disorder, Alzheimer's disease, Parkinson's disease, Huntington's chorea, multiple sclerosis, cognitive impairment, head injury, spinal cord injury, stroke, epilepsy, dyskinesias, amyotrophic lateral sclerosis, neurodegeneration associated with a bacterial or chronic infection, pain, diabetic neuropathy, migraine, cerebral ischemia, schizophrenia, encephalitis, autism and an autism spectrum disorder, a memory and learning disorder, obsessive compulsive disorder, attention deficit hyperactivity disorder (ADHD), and an addictive illness.
 35. The method of claim 33, wherein the disease, disorder, or medical condition is selected from the group consisting of treatment-resistant depression, major depressive disorder, and bipolar disorder. 